RGD Reference Report - Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. - Rat Genome Database

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Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury.

Authors: Valentim, L  Laurence, KM  Townsend, PA  Carroll, CJ  Soond, S  Scarabelli, TM  Knight, RA  Latchman, DS  Stephanou, A 
Citation: Valentim L, etal., J Mol Cell Cardiol. 2006 Jun;40(6):846-52. Epub 2006 May 12.
RGD ID: 1643194
Pubmed: PMID:16697404   (View Abstract at PubMed)
DOI: DOI:10.1016/j.yjmcc.2006.03.428   (Journal Full-text)

Autophagy is known to be a feature of cardiomyopathies and chronic ischaemia. Here we demonstrate that autophagy is also induced by a single cycle of ischaemia/reperfusion (I/R in neonatal and adult rat cardiac myocytes). Consistent with the critical role for Beclin1 in autophagocytosis, reduction of Beclin1 expression in cardiac myocytes by RNAi reduces I/R-induced autophagy and this is associated with enhanced cell survival. Autophagy is also reduced by urocortin, an endogenous cardiac peptide which we have previously shown to reduce other forms of myocyte cell death induced by I/R. The inhibition of autophagy by urocortin is mediated in part by inhibition of Beclin1 expression, an effect which is mediated by activation of the PI3 kinase/Akt pathway but which does not involve activation of p42/p44 MAPK.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autophagy  IMP 1643194 RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autophagy pathway   ISOBecn1 (Rattus norvegicus)1643194; 1643194 RGD 
autophagy pathway   IMP 1643194 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Becn1  (beclin 1)

Genes (Mus musculus)
Becn1  (beclin 1, autophagy related)

Genes (Homo sapiens)
BECN1  (beclin 1)


Additional Information