RGD Reference Report - The effects of BMSCs transplantation on autophagy by CX43 in the hippocampus following traumatic brain injury in rats. - Rat Genome Database

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The effects of BMSCs transplantation on autophagy by CX43 in the hippocampus following traumatic brain injury in rats.

Authors: Sun, L  Gao, J  Zhao, M  Jing, X  Cui, Y  Xu, X  Wang, K  Zhang, W  Cui, J 
Citation: Sun L, etal., Neurol Sci. 2014 May;35(5):677-82. doi: 10.1007/s10072-013-1575-6. Epub 2013 Nov 13.
RGD ID: 11558018
Pubmed: PMID:24221859   (View Abstract at PubMed)
DOI: DOI:10.1007/s10072-013-1575-6   (Journal Full-text)

Traumatic brain injury (TBI) can initiate a series of complicated pathological events, and induce various types of neuronal cell death including autophagy and apoptosis. Currently, the treatment of TBI is one of the main challenges in neurobiology. In this regard, the administration of bone marrow stromal cells (BMSCs) represents a novel treatment modality for TBI. However, the protective mechanism of BMSCs was unknown in the TBI. The aim of the present study was to assess the effects of BMSCs on connexin 43(CX43) and autophagy in the hippocampus following TBI in rats. A rat model of TBI was created using a modified weight-drop device. Double-membrane structures in the process of autophagy formation were frequently observed in injured brain by electron microscopy. The levels of autophagic pathway associated proteins and CX43 were also detected by western blot analysis. Specifically, immunoblotting results showed that BMSCs treatment after TBI could down-regulate light chain 3 (LC3), Beclin-1 and CX43 expression in the hippocampus. Taken together, our results demonstrated that BMSCs were able to significantly suppress TBI-induced autophagy activity, and the potential mechanism by regulating CX43 levels.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOBecn1 (Rattus norvegicus)11558018; 11558018protein:increased expression:hippocampusRGD 
Brain Injuries  IEP 11558018protein:increased expression:hippocampusRGD 
Brain Injuries  ISOMap1lc3a (Rattus norvegicus)11558018; 11558018 RGD 
Brain Injuries  IEP 11558018 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Becn1  (beclin 1)
Map1lc3a  (microtubule-associated protein 1 light chain 3 alpha)

Genes (Mus musculus)
Becn1  (beclin 1, autophagy related)
Map1lc3a  (microtubule-associated protein 1 light chain 3 alpha)

Genes (Homo sapiens)
BECN1  (beclin 1)
MAP1LC3A  (microtubule associated protein 1 light chain 3 alpha)


Additional Information