Il2 (interleukin 2) - Rat Genome Database

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Gene: Il2 (interleukin 2) Rattus norvegicus
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Symbol: Il2
Name: interleukin 2
RGD ID: 620047
Description: Enables carbohydrate binding activity; glycosphingolipid binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of T cell activation; positive regulation of dendritic spine development; and response to tacrolimus. Located in extracellular space. Used to study cystitis. Biomarker of allergic rhinitis; brain infarction; colorectal carcinoma; and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autoimmune disease of musculoskeletal system (multiple); carcinoma (multiple); neurodegenerative disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human IL2 (interleukin 2); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-2; interleukin-2; T-cell growth factor; TCGF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau5 Iddm32
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82121,932,968 - 121,937,672 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2121,932,968 - 121,937,672 (-)EnsemblGRCr8
mRatBN7.22120,004,862 - 120,009,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2126,574,220 - 126,578,924 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,686,729 - 124,691,433 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,315,685 - 119,320,389 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,847,150 - 123,851,854 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)Ensemblrn6Rnor6.0
Rnor_5.02143,460,866 - 143,465,570 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,655,005 - 123,659,709 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2114,959,889 - 114,964,593 (-)NCBICelera
RGSC_v3.12123,599,966 - 123,604,671 (-)NCBI
Cytogenetic Map2q25NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Lung Injury  (IEP)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (IEP)
alopecia areata  (ISO)
Alzheimer's disease  (ISO)
Amebic Liver Abscess  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
anogenital venereal wart  (ISO)
Anorexia  (ISO)
Asthenia  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial infectious disease  (ISO)
Behcet's disease  (ISO)
birdshot chorioretinopathy  (ISO)
brain infarction  (IEP)
Brain Injuries  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
bullous pemphigoid  (ISO)
Carcinoma, Lewis Lung  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colorectal carcinoma  (IEP)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
cystitis  (IDA)
disease of cellular proliferation  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Entamoebiasis  (ISO)
Experimental Arthritis  (IDA,IEP)
Experimental Autoimmune Uveoretinitis  (IEP,ISO)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Femoral Fractures  (IEP)
Fever  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,IEP,IMP)
Hyperkinesis  (ISO)
Hypotension  (ISO)
inflammatory bowel disease  (ISS)
interstitial lung disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Knee Osteoarthritis  (ISO)
leishmaniasis  (ISO)
leukemia  (ISO)
leukopenia  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Neoplasms  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
major depressive disorder  (ISO)
melanoma  (ISO)
Multi-Infarct Dementia  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm, Residual  (ISO)
nephrotic syndrome  (ISO)
Neurogenic Inflammation  (IEP)
open-angle glaucoma  (ISO)
Oral Lichen Planus  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pemphigus  (ISO)
Perennial Allergic Rhinitis  (ISO)
Plaque, Atherosclerotic  (ISO)
post-traumatic stress disorder  (ISO)
primary immunodeficiency disease  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (IEP)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sensorineural hearing loss  (ISO)
severe combined immunodeficiency  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (ISS)
squamous cell carcinoma  (ISO)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
tongue squamous cell carcinoma  (IEP)
Transplant Rejection  (IMP,ISO)
type 1 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uveitis  (ISO)
Vaginal Neoplasms  (ISO)
viral hepatitis  (ISO)
vitiligo  (ISO)
Zellweger syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthaleneacetic acid  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-ethylhexan-1-ol  (ISO)
2-tert-butylhydroquinone  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4'-epidoxorubicin  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroaniline  (ISO)
4-tolyl isocyanate  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
7,8-dihydroxycoumarin  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (ISO)
aldicarb  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alprazolam  (ISO)
aluminium hydroxide  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphotericin B  (ISO)
andrographolide  (EXP)
anethole  (ISO)
anthracen-2-amine  (ISO)
arjunolic acid  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Azoxymethane  (ISO)
bathocuproine disulfonic acid  (ISO)
benzamide  (EXP)
benzene  (EXP,ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (ISO)
berberine  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
betamethasone valerate  (ISO)
betulin  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
boric acid  (EXP)
boron atom  (EXP)
bromodichloromethane  (ISO)
buprenorphine  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
Butylbenzyl phthalate  (ISO)
Butylphthalide  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP,ISO)
cannabidiol  (ISO)
Cannabinol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbamazepine  (EXP)
carbaryl  (ISO)
carbofuran  (ISO)
carbon dioxide  (EXP,ISO)
carbon nanotube  (ISO)
celecoxib  (EXP)
cerium trichloride  (ISO)
chloromethylisothiazolinone  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciprofloxacin  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citral  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coformycin  (ISO)
copper(II) nitrate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
dapsone  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
Dibenzo[a,i]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichlorvos  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethanolamine  (ISO)
digoxin  (ISO)
diiodine  (EXP,ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipyridamole  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental boron  (EXP)
elemental selenium  (EXP)
emamectin benzoate  (ISO)
endosulfan  (ISO)
erianin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
famotidine  (ISO)
fenitrothion  (EXP,ISO)
fentanyl  (ISO)
ferric oxide  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fragrance  (ISO)
fructose  (EXP)
fumigaclavine C  (ISO)
fumonisin B1  (ISO)
gamma-linolenic acid  (ISO)
Gastrodin  (ISO)
genistein  (EXP)
geranial  (ISO)
Glutathione ethyl ester  (ISO)
Goe 6976  (ISO)
graphite  (ISO)
GSK-J4  (ISO)
heroin  (ISO)
hexachlorobenzene  (EXP)
histamine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidurea  (ISO)
imiquimod  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
ionomycin  (EXP,ISO)
irinotecan  (EXP)
isoeugenol  (ISO)
isoniazide  (ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP)
isotretinoin  (EXP)
KN-93  (ISO)
L-arginine  (EXP)
lactacystin  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(II) chloride  (ISO)
lenalidomide  (ISO)
levamisole  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium carbonate  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
loperamide  (ISO)
LY294002  (ISO)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malathion  (ISO)
malonaldehyde  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
MC1568  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mesalamine  (ISO)
methadone  (ISO)
methanol  (ISO)
methiocarb  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl isocyanate  (ISO)
methylmercury chloride  (ISO)
mevinphos  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (ISO)
mitogen  (EXP,ISO)
mitomycin C  (ISO)
Mitoquinone  (ISO)
mocetinostat  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (ISO)
Monocyte locomotion inhibitory factor  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
mycophenolic acid  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
naloxone  (ISO)
naproxen  (EXP)
naringin  (ISO)
neocuproine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nilotinib  (EXP)
nitrofurazone  (ISO)
nitroprusside  (EXP)
Nivalenol  (ISO)
nonanoic acid  (ISO)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oridonin  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
Paeonol  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenanthridone  (EXP)
phenethyl caffeate  (ISO)
phenyl benzoate  (ISO)
PhIP  (ISO)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic anhydride  (ISO)
piperazine  (ISO)
piperidine  (ISO)
piperine  (ISO)
poly(I:C)  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
pomalidomide  (ISO)
prednisolone  (ISO)
proanthocyanidin  (EXP)
progesterone  (ISO)
propanil  (ISO)
prostaglandin E2  (ISO)
pyrazoles  (ISO)
Pyridostigmine bromide  (ISO)
pyrimethamine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
Rhein  (ISO)
ribavirin  (ISO)
rimexolone  (ISO)
rottlerin  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 203580  (ISO)
selenium atom  (EXP)
semaxanib  (EXP)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silychristin  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium bromate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium hexachloroplatinate  (ISO)
spironolactone  (ISO)
SR 144528  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sumatriptan  (EXP)
Sunset Yellow FCF  (ISO)
syringic acid  (ISO)
T-2 toxin  (ISO)
tacrolimus (anhydrous)  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
Terfenadine  (ISO)
tert-butanol  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-anethole  (ISO)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
Tributyltin oxide  (EXP,ISO)
tributyrin  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triethanolamine  (ISO)
trimellitic anhydride  (ISO)
tropisetron  (EXP)
Tungsten carbide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
verrucarin A  (ISO)
vincristine  (EXP)
vitamin E  (EXP)
warfarin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
cell surface receptor signaling pathway via STAT  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
G protein-coupled receptor signaling pathway  (IMP)
gene expression  (ISO)
immune response  (IEA)
immune system process  (IEA)
interleukin-2-mediated signaling pathway  (IBA,IEA,ISO)
leukocyte activation involved in immune response  (IEA,ISO)
negative regulation of B cell apoptotic process  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of lymphocyte proliferation  (ISO)
negative regulation of protein phosphorylation  (IDA)
negative regulation of T-helper 17 cell differentiation  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of dendritic spine development  (IDA)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-17 production  (IEA,ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of lymphocyte differentiation  (IEA)
positive regulation of plasma cell differentiation  (ISO)
positive regulation of protein phosphorylation  (IDA)
positive regulation of regulatory T cell differentiation  (IDA)
positive regulation of T cell differentiation  (IDA)
positive regulation of T cell proliferation  (IDA,IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of T cell homeostatic proliferation  (ISO)
response to ethanol  (IDA)
response to tacrolimus  (IEP)

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
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PMID:37464198  


Genomics

Comparative Map Data
Il2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82121,932,968 - 121,937,672 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2121,932,968 - 121,937,672 (-)EnsemblGRCr8
mRatBN7.22120,004,862 - 120,009,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2126,574,220 - 126,578,924 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,686,729 - 124,691,433 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,315,685 - 119,320,389 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,847,150 - 123,851,854 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)Ensemblrn6Rnor6.0
Rnor_5.02143,460,866 - 143,465,570 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,655,005 - 123,659,709 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2114,959,889 - 114,964,593 (-)NCBICelera
RGSC_v3.12123,599,966 - 123,604,671 (-)NCBI
Cytogenetic Map2q25NCBI
IL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,451,470 - 122,456,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,451,470 - 122,456,725 (-)Ensemblhg38GRCh38
GRCh374123,372,625 - 123,377,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,592,075 - 123,597,100 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344123,730,232 - 123,735,485NCBI
Celera4120,756,030 - 120,761,055 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,099,231 - 119,104,256 (-)NCBIHuRef
CHM1_14123,349,113 - 123,354,138 (-)NCBICHM1_1
T2T-CHM13v2.04125,755,609 - 125,760,864 (-)NCBIT2T-CHM13v2.0
Il2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,174,862 - 37,180,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,174,672 - 37,180,108 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38337,120,713 - 37,125,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,120,523 - 37,125,959 (-)Ensemblmm10GRCm38
MGSCv37337,019,635 - 37,024,876 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36337,312,271 - 37,317,502 (-)NCBIMGSCv36mm8
Celera337,007,247 - 37,012,480 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.3NCBI
Il2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,162,467 - 18,168,265 (+)Ensembl
ChiLan1.0NW_00495542818,163,010 - 18,168,157 (+)NCBIChiLan1.0ChiLan1.0
IL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,236,205 - 120,241,463 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,502,088 - 120,507,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,637,328 - 114,642,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,782,563 - 125,787,819 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,782,563 - 125,787,984 (-)EnsemblpanPan2panpan1.1
IL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,750,780 - 17,756,394 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,750,780 - 17,756,394 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1917,968,837 - 17,974,439 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01917,869,103 - 17,874,712 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,869,103 - 17,874,712 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,821,680 - 17,827,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01918,101,949 - 18,107,555 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,572,248 - 18,577,858 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,520,154 - 65,524,908 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,594,953 - 1,599,625 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,594,953 - 1,599,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,640,944 - 101,645,609 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18101,640,938 - 101,645,683 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,797,437 - 108,802,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,729,635 - 69,736,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,730,282 - 69,734,969 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603748,691,838 - 48,697,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247772,885,535 - 2,890,453 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247772,885,537 - 2,890,453 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13116,891,667 - 116,896,372 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il2
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:37
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000023327
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
UniSTS:143556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22120,009,437 - 120,009,507 (+)MAPPERmRatBN7.2
Rnor_6.02123,851,726 - 123,851,795NCBIRnor6.0
Rnor_5.02143,465,442 - 143,465,511UniSTSRnor5.0
RGSC_v3.42123,659,581 - 123,659,650UniSTSRGSC3.4
Celera2114,964,465 - 114,964,534UniSTS
Cytogenetic Map2q25UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
8 3 6 21 19 29 5 72 5 4 108 85 3 12 9 23 24

Sequence


Ensembl Acc Id: ENSRNOT00000023327   ⟹   ENSRNOP00000023327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2121,932,968 - 121,937,672 (-)Ensembl
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)Ensembl
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)Ensembl
RefSeq Acc Id: NM_053836   ⟹   NP_446288
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82121,932,968 - 121,937,672 (-)NCBI
mRatBN7.22120,004,862 - 120,009,566 (-)NCBI
Rnor_6.02123,847,150 - 123,851,854 (-)NCBI
Rnor_5.02143,460,866 - 143,465,570 (-)NCBI
RGSC_v3.42123,655,005 - 123,659,709 (-)RGD
Celera2114,959,889 - 114,964,593 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446288 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41427 (Get FASTA)   NCBI Sequence Viewer  
  EDM01295 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023327
  ENSRNOP00000023327.1
GenBank Protein P17108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446288   ⟸   NM_053836
- Peptide Label: precursor
- UniProtKB: P17108 (UniProtKB/Swiss-Prot),   A6IHZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023327   ⟸   ENSRNOT00000023327

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17108-F1-model_v2 AlphaFold P17108 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620047 AgrOrtholog
BioCyc Gene G2FUF-53309 BioCyc
Ensembl Genes ENSRNOG00000017348 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023327 ENTREZGENE
  ENSRNOT00000023327.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-2 UniProtKB/Swiss-Prot
  IL-2_CS UniProtKB/Swiss-Prot
KEGG Report rno:116562 UniProtKB/Swiss-Prot
NCBI Gene 116562 ENTREZGENE
PANTHER INTERLEUKIN-2 UniProtKB/Swiss-Prot
  INTERLEUKIN-2 UniProtKB/Swiss-Prot
Pfam IL2 UniProtKB/Swiss-Prot
PhenoGen Il2 PhenoGen
PRINTS INTERLEUKIN2 UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017348 RatGTEx
SMART IL2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A6IHZ7 ENTREZGENE, UniProtKB/TrEMBL
  IL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Il2  interleukin 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il2  interleukin 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process involved in contraction in vetricular myocytes 727354
gene_regulation mRNA level dramatically increases after cyclophosphamide (CYP)-induced cystitis 625630