Gene:	Il2 ( Rattus norvegicus ) interleukin 2
Description:	cytokine produced by T-cells in response to antigen or mitogen stimulation
ArrayIDs:	6521636; M22899_at; 6105073; GE21772; 1369596_at; 6017714; 5674282; 6259671; 5905794; A_43_P12952;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Eau5 - Experimental allergic uveoretinitis QTL 5 Iddm32 - Insulin dependent diabetes mellitus QTL 32
Homologs
Homo sapiens: IL2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Il2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Il2 genome assembly 3.1 2 123599966 - 123604671     Rat Celera Assembly 2 114959889 - 114964593     RGSC genome assembly v3.4 2 123655005 - 123659709     Cytogenetic 2 q25 Mus musculus Il2 Mouse genome assembly build 36.1 3 37019644 - 37024875     Cytogenetic 3 3 B-C Homo sapiens IL2 human genome assembly 4 123730232 - 123735485     Human genome assembly build 36.2 4 123592075 - 123597330     Cytogenetic 4 q26-q27   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  growth factor activity,  glycosphingolipid binding ...  (details...)
Biological Process	Note Reference involved in contraction in vetricular myocytes 727354 Gene Ontology negative regulation of heart contraction,  positive regulation of isotype switching to IgG isotypes,  positive regulation of transcription from RNA polymerase II promoter ...  (details...)
Cellular Component	Gene Ontology extracellular space,  extracellular region (details...)
Disease	Ontology Diabetes Mellitus, Insulin-Dependent,  Severe Combined Immunodeficiency (details...)
Regulation	Note Reference mRNA level dramatically increases after cyclophosphamide (CYP)-induced cystitis 625630
External Links
Databases	DATABASE ID SOURCE SMART: IL2 IPI PROSITE: INTERLEUKIN_2 IPI ProDom: Interleukin-2 IPI UNIPARC: UPI000012D4B6 IPI KEGG Report: rno:116562 ENTREZGENE HomoloGene Group ID: 488 ENTREZGENE Germonline: 620047 Pfam: IL2 IPI KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04940 ENTREZGENE KEGG Pathway: 05332 ENTREZGENE KEGG Pathway: 04060 ENTREZGENE KEGG Pathway: 05320 ENTREZGENE KEGG Pathway: 05330 ENTREZGENE InterPro: Interleukin-2. IPI InterPro: 4_helix_cytokine_core. IPI InterPro: 4_helix_cytokine-like_core. IPI Ensembl Protein: ENSRNOP00000023327 IPI IPI: IPI00213555 IPI Gene3D-CATH: 4_helix_cytokine_core IPI Entrez Gene: Il2 ENTREZGENE UniProt: IL2_RAT IPI Ensembl Genes: ENSRNOG00000017348 IPI Superfamily-SCOP: 4_helix_cytokine IPI PANTHER: Interleukin-2 IPI PRINTS: INTERLEUKIN2. IPI
Sequences	Nucleotide: M22899 Get FASTA Search GEO Profiles Nucleotide: NM_053836 Get FASTA Search GEO Profiles Nucleotide: CH473961 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: NP_446288 Get FASTA Protein: EDM01295 Get FASTA Protein: AAA41427 Get FASTA Protein: P17108 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 9871
References
Curated References	18 references in RGD related to Il2
Other References	22 other references at PubMed related to Il2
Database Information
RGD ID	620047
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Il2 interleukin 2 APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Il2 interleukin 2 PROVISIONAL Symbol and Name status set to provisional 70820