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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il2
Name: interleukin 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of IL2 proteinPMID:34037972
Il2multiple interactionsEXP 6480464CTDPhloretin inhibits the reaction [Arsenic Trioxide results in increased expression of IL2 protein]PMID:34037972
Il2decreases expressionISOIL2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of IL2 proteinPMID:34108876
Il2decreases expressionISOIl2 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of IL2 mRNA; Arsenic Trioxide results in decreased expression of IL2 proteinPMID:23802174 PMID:29049341 PMID:37166470
Il2multiple interactionsISOIl2 (Mus musculus)6480464CTD[Arsenic Trioxide results in increased abundance of arsenite] which results in increased expression of IL2 proteinPMID:36791901
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