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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620047 Species: Rattus norvegicus RGD Object: Gene Symbol: Il2 Name: interleukin 2

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:730858	6480464	CTD	IL2 protein results in decreased activity of Tretinoin	PMID:11171635
multiple interactions	ISO	RGD:730858	6480464	CTD	Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]	PMID:12421932
decreases expression	ISO	RGD:730858	6480464	CTD	Tretinoin results in decreased expression of IL2 protein Tretinoin results in decreased expression of IL2 mRNA	PMID:17118196
increases expression	ISO	RGD:730858	6480464	CTD	Tretinoin results in increased expression of IL2 protein	PMID:14978018
increases expression	EXP		6480464	CTD	Tretinoin results in increased expression of IL2 protein Tretinoin results in increased expression of IL2 mRNA	PMID:16309824
multiple interactions	EXP		6480464	CTD	IL2 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	PMID:11171635