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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620047 Species: Rattus norvegicus RGD Object: Gene Symbol: Il2 Name: interleukin 2

Acc ID: CHEBI:15368 Term: acrolein Definition: An enal that has formula C3H4O. CasRN: 107-02-8 Chemical ID: MESH:D000171

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730858	6480464	CTD	Acrolein inhibits the reaction [NFKB1 protein binds to IL2 promoter]	PMID:17491020
decreases secretion	ISO	RGD:730858	6480464	CTD	Acrolein results in decreased secretion of IL2 protein	PMID:17491020