Gene:	Ctla4 ( Rattus norvegicus ) cytotoxic T-lymphocyte-associated protein 4
Description:	immunoregulatory receptor expressed on the surface of T and B lymphocytes
Synonyms:	Cd152; CD152 antigen; sCTLA4; CTLA-4;
ArrayIDs:	1387638_a_at; 5830925; 5696651; U37121_at; U90271_s_at; 6715526; 5998448; 5778787; A_44_P109648; 5918853; 6013229; A_43_P15458; 5781103;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: CTLA4     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ctla4     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ctla4 genome assembly 3.1 9 59642754 - 59648282     Rat Celera Assembly 9 59742231 - 59747758     RGSC genome assembly v3.4 9 59495773 - 59501300     Cytogenetic 9 q31 Mus musculus Ctla4 Mouse genome assembly build 36.1 1 60965869 - 60972674     Cytogenetic 1 1 C Homo sapiens CTLA4 human genome assembly 2 204558016 - 204564189     Human genome assembly build 36.2 2 204440754 - 204446928     Cytogenetic 2 q33   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology receptor activity,  protein binding (details...)
Biological Process	Gene Ontology negative regulation of T cell proliferation,  negative regulation of regulatory T cell differentiation,  negative regulation of immune response (details...)
Cellular Component	Gene Ontology perinuclear region of cytoplasm,  clathrin-coated endocytic vesicle,  external side of plasma membrane ...  (details...)
Disease	Ontology Thyroiditis, Autoimmune,  Graves' Disease,  Celiac Disease ...  (details...)
Phenotype	Ontology increased T cell proliferation,  infiltration of lymphocytes/plasma cells,  increased immunoglobulin level (details...)
Transcript structure	Note Reference alternatively spliced transcripts lack the exon 3 encoded transmembrane domain 634642
External Links
Databases	DATABASE ID SOURCE SMART: IG IPI PROSITE: IG_LIKE IPI UNIPARC: UPI00000E8AB6 IPI UNIPARC: UPI00000E75B9 IPI KEGG Report: rno:63835 ENTREZGENE HomoloGene Group ID: 3820 ENTREZGENE Germonline: 61975 Pfam: V-set IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04514 ENTREZGENE KEGG Pathway: 05320 ENTREZGENE InterPro: Ig_sub. IPI InterPro: Ig_V-set. IPI InterPro: Ig-like_fold. IPI InterPro: CTLA4. IPI InterPro: Ig-like. IPI IPI: IPI00326928 IPI IPI: IPI00209245 IPI Ensembl Protein: ENSRNOP00000013941 IPI Ensembl Protein: ENSRNOP00000014011 IPI Gene3D-CATH: Ig-like_fold IPI Entrez Gene: Ctla4 ENTREZGENE UniProt: Q792X0_RAT IPI UniProt: Q9Z1A7_RAT IPI UniProt: Q792X1_RAT IPI UniProt: Q62859_RAT IPI Ensembl Genes: ENSRNOG00000010336 IPI PRINTS: CTLANTIGEN4. IPI
Sequences	Nucleotide: NM_031674 Get FASTA Search GEO Profiles Nucleotide: AF012712 Get FASTA Search GEO Profiles Nucleotide: AF012713 Get FASTA Search GEO Profiles Nucleotide: CH473965 Get FASTA Search GEO Profiles Nucleotide: U37121 Get FASTA Search GEO Profiles Nucleotide: U90271 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: AAC52502 Get FASTA Protein: AAD00697 Get FASTA Protein: Q62859 Get FASTA Protein: Q792X0 Get FASTA Protein: Q792X1 Get FASTA Protein: Q9Z1A7 Get FASTA Protein: AAD04806 Get FASTA Protein: AAD04805 Get FASTA Protein: NP_113862 Get FASTA Protein: EDL98923 Get FASTA Protein: EDL98924 Get FASTA (View all 11 Protein Accessions)
Clusters	UniGene: 10259
References
Curated References	24 references in RGD related to Ctla4
Other References	6 other references at PubMed related to Ctla4
Database Information
RGD ID	61975
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Ctla4 cytotoxic T-lymphocyte-associated protein 4 Cd152 CD152 antigen APPROVED Symbol and Name updated 1299863 10-JUN-02: Cd152 CD152 antigen APPROVED Name updated 70584