RGD Reference Report - [Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene]. - Rat Genome Database

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[Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene].

Authors: Xu, XY  Liu, YF  Yi, J  Ke, YB  Yuan, JH  Huang, HY  Mao, JY  Mao, KL 
Citation: Xu XY, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Nov;29(11):816-9.
RGD ID: 7411700
Pubmed: PMID:22357516   (View Abstract at PubMed)

OBJECTIVE: To study mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4 and T-bet) in peripheral blood of the patients with allergic dermatitis induced by trichloroethylene (TCE). METHODS: The peripheral blood samples were collected from 8 healthy workers (control group) and 8 patients with allergic dermatitis induced by TCE (case group). Real-time quantitative PCR was applied to detect mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4, T-bet). RESULTS: The mRNA expression levels of Foxp3, GATA3 and CTLA4 genes increased by 115%, 97% and 241% in case group, as compared with control group (P < 0.01). The mRNA expression level of T-bet gene decreased by 47% in case group, as compared with control group (P < 0.01). CONCLUSION: The mRNA expression levels of some immune-related genes changed in patients with allergic dermatitis induced by TCE, those genes may play an important role in TCE-induced allergy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
atopic dermatitis  IEP 7411700mRNA:increased expression:blood:RGD 
atopic dermatitis  ISOCTLA4 (Homo sapiens)7411700; 7411700mRNA:increased expression:blood:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)

Genes (Mus musculus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)

Genes (Homo sapiens)
CTLA4  (cytotoxic T-lymphocyte associated protein 4)


Additional Information