RGD Reference Report - The role of CTLA-4 in murine contact hypersensitivity. - Rat Genome Database

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The role of CTLA-4 in murine contact hypersensitivity.

Authors: Nuriya, S  Enomoto, S  Azuma, M 
Citation: Nuriya S, etal., J Invest Dermatol. 2001 May;116(5):764-8.
RGD ID: 7421503
Pubmed: PMID:11348467   (View Abstract at PubMed)
DOI: DOI:10.1046/j.1523-1747.2001.01338.x   (Journal Full-text)

CTLA-4 (CD152) shares its ligand with a costimulatory molecule, CD28, and functions as a negative regulator in T cell activation. We examined the role of CTLA-4 in both induction and effector phases of contact hypersensitivity induced by using two allergens. Treatment with anti-CTLA-4 monoclonal antibody at sensitization, but not at challenge, significantly enhanced Th1- and Th2-dominant contact hypersensitivity reactions elicited by dinitrofluorobenzene and fluorescein isothiocyanate, respectively. CTLA-4 was faintly expressed on regional lymph node T cells even in naive mice, and its transcription determined by reverse transcriptase polymerase chain reaction was clearly enhanced at 72 h after sensitization. Treatment with anti-CTLA-4 monoclonal antibody at sensitization significantly augmented the total cell number in regional lymph nodes and proliferative responses of T cells against specific haptens. This higher sensitivity in lymph node T cells against specific haptens was maintained over the month after treatment. Our results suggest that CTLA-4 on T cells may regulate the induction of antigen-specific T cells in the regional lymph nodes in allergic contact dermatitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
contact dermatitis  ISOCtla4 (Mus musculus)7421503; 7421503 RGD 
contact dermatitis  IMP 7421503 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)

Genes (Mus musculus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)

Genes (Homo sapiens)
CTLA4  (cytotoxic T-lymphocyte associated protein 4)


Additional Information