RGD Reference Report - CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis. - Rat Genome Database

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CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis.

Authors: Harbo, HF  Celius, EG  Vartdal, F  Spurkland, A 
Citation: Harbo HF, etal., Tissue Antigens 1999 Jan;53(1):106-10.
RGD ID: 1358538
Pubmed: PMID:10082437   (View Abstract at PubMed)

The human cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene may be a candidate susceptibility gene in multiple sclerosis (MS). In this study the distribution of the dimorphisms of exon 1 (+49 A/G) and promoter (-318 C/T) regions of the CTLA4 gene was analysed in 296 unrelated Norwegian MS patients and 271 matched controls by polymerase chain reaction and restriction fragment length polymorphism. The frequency of the exon 1 (+49) A-G genotype was increased in patients (57%) compared with controls (44%) (Pcorrected=0.01), and even more increased in patients with relapsing remitting MS (59%) (Pcorrected=0.006). No other significant differences were found between clinical subgroups of patients or between HLA-DRB1*1501, DQB1*0602-positive and negative patients and controls.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
multiple sclerosis  IAGP 1358538 RGD 
multiple sclerosis  ISOCTLA4 (Homo sapiens)1358538; 1358538 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)

Genes (Mus musculus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)

Genes (Homo sapiens)
CTLA4  (cytotoxic T-lymphocyte associated protein 4)


Additional Information