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Gene: Trpc3 (transient receptor potential cation channel, subfamily C, member 3) Rattus norvegicus

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Symbol:

Trpc3

Name:

transient receptor potential cation channel, subfamily C, member 3

RGD ID:

61973

Description:

Enables calcium-activated cation channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ion channel protein; short transient receptor potential channel 3; transient receptor potential cation channel subfamily C member 3; transient receptor protein 3; trp-related protein 3; TrpC3c; Trrp3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Trpc3^em2Mcwi ; Trpc3^em1Mcwi

Genetic Models:

SS-Trpc3^em1Mcwi ; SS-Trpc3^em2Mcwi

Candidate Gene For:

Cm49

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	121,409,436 - 121,487,095 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	121,409,436 - 121,475,823 (-)	Ensembl				GRCr8
mRatBN7.2	2	119,481,313 - 119,619,333 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	119,481,400 - 119,558,855 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	126,036,120 - 126,102,387 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	124,148,616 - 124,214,886 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	118,777,565 - 118,843,835 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	123,329,954 - 123,467,574 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	123,329,875 - 123,407,496 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	142,945,309 - 143,022,844 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	123,117,180 - 123,184,016 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	114,439,430 - 114,505,661 (-)	NCBI		Celera
RGSC_v3.1	2	123,062,239 - 123,110,364 (-)	NCBI
Cytogenetic Map	2	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (IEP)

bipolar disorder (ISO)

cerebellar ataxia type 41 (ISO)

hypertension (ISO)

pulmonary hypertension (ISO)

Spinocerebellar Ataxias (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

1-Oleoyl-2-acetyl-sn-glycerol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-trinitrobenzenesulfonic acid (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

allethrin (EXP)

alpha-Zearalanol (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

asbestos (ISO)

ATP (ISO)

atrazine (EXP)

Azoxymethane (ISO)

barium(0) (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

caffeine (ISO)

calcium atom (EXP,ISO)

calcium(0) (EXP,ISO)

carbachol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

CHIR 99021 (EXP)

chlorpyrifos (ISO)

cyclosporin A (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

DDE (ISO)

decabromodiphenyl ether (EXP)

dextran sulfate (ISO)

dimethylarsinic acid (ISO)

doxorubicin (EXP,ISO)

fenvalerate (EXP)

gadolinium atom (ISO)

gentamycin (EXP)

GW 4064 (ISO)

ketamine (EXP)

maneb (ISO)

methacholine chloride (ISO)

methoxychlor (EXP)

methylarsonic acid (ISO)

Moniliformin (ISO)

okadaic acid (ISO)

ozone (ISO)

paclitaxel (ISO)

paraquat (EXP,ISO)

phenylephrine (EXP)

phorbol 13-acetate 12-myristate (EXP)

pioglitazone (ISO)

pyrethrins (EXP)

rotenone (EXP)

salvianolic acid B (EXP)

SKF-96365 hydrochloride (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

testosterone (EXP)

tetraphene (ISO)

thapsigargin (EXP,ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (ISO)

UTP (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion transmembrane transport (IBA,IEA,ISO)

calcium ion transport (IEA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

positive regulation of calcium ion transport into cytosol (IEA,ISO)

positive regulation of cardiac muscle hypertrophy in response to stress (IEA,ISO)

regulation of cytosolic calcium ion concentration (IBA)

response to ATP (IEA,ISO)

response to calcium ion (IEA,ISO)

single fertilization (IBA)

transmembrane transport (IEA)

Cellular Component

cation channel complex (IBA)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

calcium channel activity (IEA,ISO)

calcium-activated cation channel activity (IDA)

inositol 1,4,5 trisphosphate binding (IBA,IEA,ISO)

metal ion binding (IEA)

monoatomic ion channel activity (IEA)

protein binding (ISO)

store-operated calcium channel activity (IBA,IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Tissue expression of TRPC3 and TRPC6 in hypertensive Munich Wistar Fromter rats showing proteinuria.	Liu Y, etal., Am J Nephrol. 2010;31(1):36-44. doi: 10.1159/000254060. Epub 2009 Oct 30.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	A calcium-activated cation current by an alternatively spliced form of Trp3 in the heart.	Ohki G, etal., J Biol Chem 2000 Dec 15;275(50):39055-60.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10.	Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.	Yu Y, etal., Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13861-6. Epub 2004 Sep 9.

Additional References at PubMed

PMID:9368034	PMID:12938168	PMID:14505576	PMID:15199065	PMID:15225788	PMID:15297455	PMID:15327778	PMID:15604128	PMID:15623527	PMID:15672411	PMID:15728370	PMID:16280289
PMID:16950785	PMID:17082763	PMID:17141310	PMID:17158171	PMID:17494704	PMID:17699554	PMID:17903696	PMID:18388325	PMID:18502908	PMID:19029480	PMID:19287093	PMID:19741172
PMID:20107112	PMID:20378853	PMID:20426773	PMID:20933035	PMID:21062895	PMID:21098487	PMID:21316341	PMID:21670282	PMID:22129453	PMID:22207762	PMID:22721989	PMID:22787041
PMID:22926417	PMID:23045459	PMID:23529532	PMID:23602965	PMID:23776229	PMID:24811179	PMID:24844791	PMID:24965271	PMID:25467798	PMID:25479966	PMID:25873305	PMID:25958233
PMID:26219954	PMID:26598506	PMID:27833156	PMID:27899482	PMID:28495616	PMID:28697491	PMID:28711865	PMID:28764936	PMID:29435486	PMID:29748835	PMID:30318928	PMID:34497367
PMID:36613540	PMID:36669577

Genomics

Comparative Map Data

Trpc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	121,409,436 - 121,487,095 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	121,409,436 - 121,475,823 (-)	Ensembl				GRCr8
mRatBN7.2	2	119,481,313 - 119,619,333 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	119,481,400 - 119,558,855 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	126,036,120 - 126,102,387 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	124,148,616 - 124,214,886 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	118,777,565 - 118,843,835 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	123,329,954 - 123,467,574 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	123,329,875 - 123,407,496 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	142,945,309 - 143,022,844 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	123,117,180 - 123,184,016 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	114,439,430 - 114,505,661 (-)	NCBI		Celera
RGSC_v3.1	2	123,062,239 - 123,110,364 (-)	NCBI
Cytogenetic Map	2	q25	NCBI

TRPC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	121,874,481 - 121,952,060 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	121,874,481 - 121,952,060 (-)	Ensembl			hg38	GRCh38
GRCh37	4	122,795,636 - 122,873,215 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	123,019,882 - 123,074,061 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	123,158,037 - 123,212,216	NCBI
Celera	4	120,186,020 - 120,258,701 (-)	NCBI		Celera
Cytogenetic Map	4	q27	NCBI
HuRef	4	118,526,892 - 118,599,598 (-)	NCBI		HuRef
CHM1_1	4	122,776,636 - 122,849,349 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	125,178,529 - 125,256,098 (-)	NCBI		T2T-CHM13v2.0

Trpc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	36,674,626 - 36,744,276 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	36,674,631 - 36,744,316 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	36,620,482 - 36,690,429 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	36,620,482 - 36,690,167 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	36,519,404 - 36,589,089 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	36,812,122 - 36,863,152 (-)	NCBI		MGSCv36	mm8
Celera	3	36,505,427 - 36,575,273 (-)	NCBI		Celera
Cytogenetic Map	3	B	NCBI
cM Map	3	17.93	NCBI

Trpc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	18,628,890 - 18,678,906 (+)	Ensembl
ChiLan1.0	NW_004955428	18,628,951 - 18,678,525 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRPC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	119,675,137 - 119,748,732 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	119,944,205 - 120,017,773 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	114,079,395 - 114,153,014 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	125,217,086 - 125,288,918 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	125,217,086 - 125,289,014 (-)	Ensembl			panPan2	panpan1.1

TRPC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	18,207,565 - 18,272,551 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	18,207,417 - 18,271,828 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	18,424,474 - 18,489,427 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	18,325,131 - 18,390,132 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	18,257,209 - 18,389,851 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	18,276,335 - 18,341,249 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	18,557,985 - 18,622,931 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	19,033,797 - 19,098,726 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Trpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	65,875,569 - 65,989,487 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936662	1,129,278 - 1,171,378 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936662	1,130,555 - 1,171,352 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRPC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	102,129,611 - 102,206,946 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	102,129,539 - 102,206,512 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	109,324,967 - 109,402,046 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRPC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	69,160,569 - 69,233,322 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	69,158,867 - 69,231,858 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	48,122,249 - 48,196,700 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trpc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624777	2,153,265 - 2,232,449 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624777	2,154,887 - 2,232,476 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Trpc3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	117,306,258 - 117,367,269 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Trpc3
217 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	69
Count of miRNA genes:	60
Interacting mature miRNAs:	68
Transcripts:	ENSRNOT00000046700
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	105628029	150628029	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	82947902	127947902	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	84056790	132859658	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
2317886	Alcrsp23	Alcohol response QTL 23	2.4	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	95142371	140142371	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
2317058	Aia13	Adjuvant induced arthritis QTL 13	2.9		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	2	78269809	123269809	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	120039407	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	100807373	145807373	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	106869825	151869825	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	120039407	151869825	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	93602631	145807373	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	82214549	127214549	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
7488933	Bp368	Blood pressure QTL 368		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	104957381	149957381	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	120339555	165339555	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	114032149	150226270	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	114440891	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1354594	Despr10	Despair related QTL 10		2e-06	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	116804572	161804572	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat

Markers in Region

D2Rat340

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	121,439,886 - 121,440,099 (+)	Marker Load Pipeline
Rnor_6.0	2	123,360,405 - 123,360,640	NCBI	Rnor6.0
Rnor_5.0	2	142,975,758 - 142,975,970	UniSTS	Rnor5.0
RGSC_v3.4	2	123,147,918 - 123,148,131	RGD	RGSC3.4
RGSC_v3.4	2	123,147,919 - 123,148,131	UniSTS	RGSC3.4
Celera	2	114,469,851 - 114,470,051	UniSTS
RGSC_v3.1	2	123,092,880 - 123,093,093	RGD
SHRSP x BN Map	2	44.4298	RGD
SHRSP x BN Map	2	44.4298	UniSTS
Cytogenetic Map	2	q25	UniSTS

D2Got77

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	119,519,366 - 119,519,543 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	123,368,030 - 123,368,208	NCBI	Rnor6.0
Rnor_5.0	2	142,983,360 - 142,983,536	UniSTS	Rnor5.0
RGSC_v3.4	2	123,155,520 - 123,155,699	RGD	RGSC3.4
RGSC_v3.4	2	123,155,521 - 123,155,699	UniSTS	RGSC3.4
Celera	2	114,477,427 - 114,477,605	UniSTS
RGSC_v3.1	2	123,100,483 - 123,100,661	RGD
RH 3.4 Map	2	675.0	RGD
RH 3.4 Map	2	675.0	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH129709

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	119,549,285 - 119,549,473 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	123,397,941 - 123,398,128	NCBI	Rnor6.0
Rnor_5.0	2	143,013,259 - 143,013,446	UniSTS	Rnor5.0
RGSC_v3.4	2	123,186,812 - 123,186,999	UniSTS	RGSC3.4
Celera	2	114,507,201 - 114,507,388	UniSTS
RH 3.4 Map	2	673.4	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH144026

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	119,481,538 - 119,481,642 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	123,330,180 - 123,330,283	NCBI	Rnor6.0
Rnor_5.0	2	142,945,535 - 142,945,638	UniSTS	Rnor5.0
RGSC_v3.4	2	123,117,319 - 123,117,422	UniSTS	RGSC3.4
Celera	2	114,439,569 - 114,439,672	UniSTS
RH 3.4 Map	2	675.3	UniSTS
Cytogenetic Map	2	q25	UniSTS

BE116826

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	119,496,187 - 119,496,392 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	123,344,829 - 123,345,033	NCBI	Rnor6.0
Rnor_5.0	2	142,960,184 - 142,960,388	UniSTS	Rnor5.0
RGSC_v3.4	2	123,132,341 - 123,132,545	UniSTS	RGSC3.4
Celera	2	114,454,216 - 114,454,420	UniSTS
RH 3.4 Map	2	673.4	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH139923

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	119,499,847 - 119,500,049 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	123,348,489 - 123,348,690	NCBI	Rnor6.0
Rnor_5.0	2	142,963,844 - 142,964,045	UniSTS	Rnor5.0
RGSC_v3.4	2	123,136,001 - 123,136,202	UniSTS	RGSC3.4
Celera	2	114,457,934 - 114,458,135	UniSTS
RH 3.4 Map	2	676.5	UniSTS
Cytogenetic Map	2	q25	UniSTS

Genetic Models

This gene Trpc3 is modified in the following models/strains:

SS-Trpc3^em1Mcwi SS-Trpc3^em2Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	153	64	63	32	27	32	6	263	127	11	128	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF061875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF313481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF313482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JN160741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000046700 ⟹ ENSRNOP00000046270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	121,409,436 - 121,475,823 (-)	Ensembl
mRatBN7.2 Ensembl	2	119,481,400 - 119,547,707 (-)	Ensembl
Rnor_6.0 Ensembl	2	123,330,041 - 123,396,386 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079004 ⟹ ENSRNOP00000071693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	119,481,400 - 119,529,783 (-)	Ensembl
Rnor_6.0 Ensembl	2	123,330,705 - 123,396,147 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080207 ⟹ ENSRNOP00000075444

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	121,409,436 - 121,465,969 (-)	Ensembl
mRatBN7.2 Ensembl	2	119,481,400 - 119,558,855 (-)	Ensembl
Rnor_6.0 Ensembl	2	123,329,875 - 123,407,496 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109104 ⟹ ENSRNOP00000095733

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	121,409,436 - 121,475,823 (-)	Ensembl
mRatBN7.2 Ensembl	2	119,481,400 - 119,547,707 (-)	Ensembl

RefSeq Acc Id:

NM_001415005 ⟹ NP_001401934

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	121,409,436 - 121,475,823 (-)	NCBI
mRatBN7.2	2	119,481,313 - 119,547,704 (-)	NCBI

RefSeq Acc Id:

XM_008760941 ⟹ XP_008759163

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	121,409,436 - 121,475,847 (-)	NCBI
mRatBN7.2	2	119,481,313 - 119,547,750 (-)	NCBI
Rnor_6.0	2	123,329,954 - 123,396,403 (-)	NCBI

Sequence:

show sequence

AGGGAAACCGCGCCGTCTCGCCGCGATGCTGTCGGACCGGCAGACCACGCACAGCCGGCATCGC
GGCCGCGGACCCCGAGCTCCGCTGCAGGTCGCGCGCTCGGCCCGGGCGGCCCCGGCGCCGCGGC
CCGGGTGCTTGACTCAGAGCGGCTGGGCTGCTGACTGCGGGCGGCAAGGAGCTCGGCCGCTATG
TCCACCAAGGTCAAGAAGTGCCGGGAGCCCGCGAGGGTGACCTTGCCCGCGCCGGAGGAGGAGG
ATGGCGAGGCCGAGGGAGCCGAGCCGCAGCGCCGCCGCCGGGGCTGGAGGGGCGTCAACGGCGG
GCTGGAGCCGCCCTGCCCGCGCGCGCCGCCGTCCCCGGGGCCCGACGCGTCGTCGGAGGGCAGT
CCATCCAGGTGGCGCACAGCAGGGATGCGTGACAAGGGCAGGCGCCAGGCAGTACGTGGCCCGG
CCTTCATGTTCGGTGCTCGTGGGCCCAGCCTCACAGCTGAGGAGGAGCGCTTCCTGGACGCTGC
AGAGTACGGCAACATCCCTGTGGTGCGCAAGATGCTGGAGGAGTCTCGCACGCTCAATGTCAAC
TGCGTGGACTACATGGGCCAGAATGCGCTGCAGCTGGCCGTGGGCAATGAGCATCTGGAGGTGA
CCGAGCTGCTGCTGAAGAAGGAGAACCTGGCGCGTATCGGTGATGCGCTGCTGCTCGCCATCAG
CAAAGGCTATGTGCGCATCGTGGAGGCCATCCTAGGCCACCCAGGCTTTGCGGCCAGCCGGCGC
CTGACCCTCAGCCCTTGCGAGCAAGAACTGCGCGATGACGACTTCTATGCTTACGACGAGGATG
GCACACGCTTCTCACCTGACATCACGCCCATCATCCTGGCTGCGCATTGCCATAAATACGAGGT
GGTGCACCTGCTGCTACTCAAGGGTGCACGCATCGAGCGGCCACACGACTACTTCTGTCGCTGC
GCCGACTGTGCTGAGAAGCAAAGGCTTGATGCCTTCAGCCACTCAAGGTCTAGGATCAATGCCT
ACAAGGGACTGGCCAGCCCAGCATACTTGTCGCTGTCCAGCGAGGACCCTGTGCTCACAGCGCT
GGAACTCAGCAATGAGCTGGCCAAGCTGGCCAACATAGAGAAGGAGTTCAAGAATGACTACAGG
AAGCTCTCCATGCAGTGCAAAGACTTCGTAGTAGGTGTGCTGGACCTGTGCCGGGACTCAGAGG
AGGTGGAAGCCATTCTGAATGGAGATCTGGAATCGGTGGAACCCCTGGAGAGACACGGGCACAA
GGCGTCGCTGAGTCGGGTCAAACTTGCCATTAAATATGAAGTCAAAAAGTTTGTGGCTCACCCC
AACTGCCAACAGCAGCTTTTGACCATCTGGTACGAGAACCTCTCGGGCCTTCGGGAGCAGACCA
TCGCTATCAAGTGTCTGGTCGTGTTGGTCGTGGCCTTGGGCCTTCCATTCCTCGCCATCGGCTA
CTGGATTGCACCTTGTAGCAGGCTGGGGAAAATTCTTCGAAGCCCCTTCATGAAGTTCGTGGCT
CACGCTGCCTCCTTCATCATCTTCCTGGGTCTGCTTGTGTTCAACGCCTCAGACCGGTTTGAAG
GCATCACCACGCTGCCCAACATCACCGTTATTGACTACCCCAAGCAAATCTTCAGGGTGAAGAC
CACCCAGTTCACATGGACAGAAATGCTAATTATGGTCTGGGTTCTCGGGATGATGTGGTCTGAG
TGCAAGGAGCTGTGGCTGGAGGGGCCCCGGGAGTACATCGTGCAGCTGTGGAACGTGCTTGACT
TCGGGATGCTCTCCATCTTCATTGCTGCCTTCACCGCCAGGTTCCTAGCGTTTCTGCAAGCCAC
CAAAGCGCAGCAGTATGTGGACAGCCACGTGCAGGAGAGCGACCTGAGCGAAGTCACACTCCCA
CCAGAGGTTCAGTATTTCACCTATGCTAGAGATAAATGGCTTCCTTCTGACCCTCAGATCATAT
CGGAAGGCCTCTATGCCATAGCTGTGGTGCTCAGCTTCTCCCGGATCGCGTACATTCTCCCTGC
AAACGAGAGCTTTGGGCCCTTGCAGATCTCTCTGGGGAGGACTGTGAAGGACATATTCAAGTTC
ATGGTTCTCTTCATCATGGTGTTCCTGGCTTTCATGATTGGCATGTTCATACTTTACTCCTACT
ACCTTGGGGCCAAAGTAAACCCTGCTTTTACCACGGTTGAAGAAAGTTTCAAGACTTTGTTTTG
GTCCATATTTGGACTCTCTGAAGTGACTTCTGTTGTCCTCAAATATGACCACAAATTCATAGAG
AACATTGGCTATGTCCTTTATGGAATATACAATGTAACTATGGTGGTCGTTCTGCTCAACATGC
TGATTGCTATGATTAACAGCTCATACCAAGAAATCGAGGATGACAGTGATGTAGAGTGGAAGTT
TGCTCGTTCCAAACTCTGGCTATCCTACTTCGATGATGGAAAAACATTACCTCCACCCTTCAGT
CTGGTCCCTAGTCCAAAATCGTTTGTTTATTTCATCATGAGGATCACTAACTTTTCCAAATGCA
GGAGGAGAAGACTTCAGAAGGATCTGGAACTGGGCATGGGTAACTCAAAGTCCAGGCAGATAAT
GAAAAGACTCATAAAACGGTATGTTTTGAAAGCACAAGTAGACAAAGAAAATGATGAGGTGAAC
GAAGGTGAACTGAAAGAAATCAAGCAGGATATCTCCAGCCTTCGTTACGAACTTTTGGAAGATA
AGAGCCAAGCGACGGAGGAACTGGCCATCTTGATTCATAAACTCAGTGAGAAACTGAACCCCAG
TGCGCTGAGGTGTGAATGAGGGAGCCACATGCAGTGAGACTTTGACTCTGGCACAAATGTGGGC
AATAATATTCCTAAGTATGAAATACTTGAAAAACCGTTGTGTAAAAACTCTAGTGTTAATACCT
TCACCATGCGGAGCTTTAAAATTAACCTAGTGGGCCACAATTCCCATTACGTGAAAATGATCCC
AAGGTTGGCCTCAGCACTCCAAGCAGTGACATGCTGTTGTACTTAGAAGCCCAGTATTAATGTC
ACTGATTTTTTTTTTTTTTTTGTCATTTTTGTCTTTATGTCACCTGTTGGCCTCCAAGAGTTCC
TTGGGGGACAGGGACCACATCAATCTCATCTTTATGTCTCCAACATTTAGTGCAGTGCCTGATA
CACAGTAGGTGCTTGGTAAATGTTGAACCCAGCTGGCCTGGACAGCCAGTAGCATCCAAGAACA
CGAAAGACCATTGCTATGTAGCCTACCTTCTCATCCGAACGCTTGAAGCGATTTTTTTAAAAAT
AGAAACTGAAGGTGTTTTACGACCAGCCATGATGTGTGGAGATCTTTCTCAGACCTTTAGACAT
CACTGACAGTTCTAGGGCTTTTGAAATGCCAGGTTTAACAGTGAAATGAGCTCATTGGAAAGAT
ACATATTTAATTTCATAGGGTTGTTCAAAAACAATCATTAAAGATTTTTCTAAAATATATGCTT
GTGTCCTTTCTCTTTGTATCTGTGGTGTCATGATGTAAATTTGGTCAATAAAGAATGCTTTTCT
AA

hide sequence

RefSeq Acc Id:

XM_039103014 ⟹ XP_038958942

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	121,409,436 - 121,475,847 (-)	NCBI
mRatBN7.2	2	119,481,313 - 119,547,750 (-)	NCBI

RefSeq Acc Id:

XM_039103015 ⟹ XP_038958943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	121,409,436 - 121,487,095 (-)	NCBI
mRatBN7.2	2	119,481,313 - 119,558,823 (-)	NCBI

RefSeq Acc Id:

XM_063282439 ⟹ XP_063138509

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	121,434,312 - 121,475,849 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001401934	(Get FASTA)	NCBI Sequence Viewer
	XP_008759163	(Get FASTA)	NCBI Sequence Viewer
	XP_038958942	(Get FASTA)	NCBI Sequence Viewer
	XP_038958943	(Get FASTA)	NCBI Sequence Viewer
	XP_063138509	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC16727	(Get FASTA)	NCBI Sequence Viewer
	AAL59070	(Get FASTA)	NCBI Sequence Viewer
	AAL59071	(Get FASTA)	NCBI Sequence Viewer
	AEK22122	(Get FASTA)	NCBI Sequence Viewer
	EDM01287	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000046270
	ENSRNOP00000046270.5
	ENSRNOP00000095733
	ENSRNOP00000100915
GenBank Protein	Q9JMI9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_008759163 ⟸ XM_008760941
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2KAL8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSTKVKKCREPARVTLPAPEEEDGEAEGAEPQRRRRGWRGVNGGLEPPCPRAPPSPGPDASSEG SPSRWRTAGMRDKGRRQAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEESRTLNV NCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASR RLTLSPCEQELRDDDFYAYDEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCR CADCAEKQRLDAFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDY RKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESVEPLERHGHKASLSRVKLAIKYEVKKFVAH PNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFV AHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWS ECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTL PPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFK FMVLFIMVFLAFMIGMFILYSYYLGAKVNPAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFI ENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPF SLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRQIMKRLIKRYVLKAQVDKENDEV NEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSALRCE hide sequence

Ensembl Acc Id:

ENSRNOP00000071693 ⟸ ENSRNOT00000079004

Ensembl Acc Id:

ENSRNOP00000075444 ⟸ ENSRNOT00000080207

Ensembl Acc Id:

ENSRNOP00000046270 ⟸ ENSRNOT00000046700

RefSeq Acc Id:	XP_038958943 ⟸ XM_039103015
- Peptide Label:	isoform X3
- UniProtKB:	A0A0G2KAL8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958942 ⟸ XM_039103014
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAL8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000095733 ⟸ ENSRNOT00000109104

RefSeq Acc Id:	NP_001401934 ⟸ NM_001415005
- UniProtKB:	Q9JMI9 (UniProtKB/Swiss-Prot), F1LNQ7 (UniProtKB/Swiss-Prot), A0A0G2KAL8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138509 ⟸ XM_063282439
- Peptide Label:	isoform X4

Protein Domains

Transient receptor ion channel

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JMI9-F1-model_v2	AlphaFold	Q9JMI9	1-836	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691293

Promoter ID:

EPDNEW_R1818

Type:

single initiation site

Name:

Trpc3_1

Description:

transient receptor potential cation channel, subfamily C, member3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	123,396,362 - 123,396,422	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61973	AgrOrtholog
BioCyc Gene	G2FUF-53314	BioCyc
Ensembl Genes	ENSRNOG00000016070	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000046700	ENTREZGENE
	ENSRNOT00000046700.6	UniProtKB/Swiss-Prot
	ENSRNOT00000080207	ENTREZGENE
	ENSRNOT00000109104	ENTREZGENE
Gene3D-CATH	1.25.40.20	UniProtKB/Swiss-Prot
InterPro	Ankyrin_rpt	UniProtKB/Swiss-Prot
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot
	Ion_trans_dom	UniProtKB/Swiss-Prot
	TRP_dom	UniProtKB/Swiss-Prot
	TRPC3_channel	UniProtKB/Swiss-Prot
	TRPC_channel	UniProtKB/Swiss-Prot
NCBI Gene	Trpc3	ENTREZGENE
PANTHER	PTHR10117	UniProtKB/Swiss-Prot
	PTHR10117:SF8	UniProtKB/Swiss-Prot
Pfam	Ank_2	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
	TRP_2	UniProtKB/Swiss-Prot
PhenoGen	Trpc3	PhenoGen
PRINTS	TRNSRECEPTRP	UniProtKB/Swiss-Prot
	TRPCHANNEL3	UniProtKB/Swiss-Prot
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016070	RatGTEx
SMART	ANK	UniProtKB/Swiss-Prot
	TRP_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48403	UniProtKB/Swiss-Prot
TIGR	TC233512
UniProt	A0A0G2KAL8	ENTREZGENE
	A0A8I6B383_RAT	UniProtKB/TrEMBL
	A0ABK0L8C4_RAT	UniProtKB/TrEMBL
	A6IHY9_RAT	UniProtKB/TrEMBL
	F1LNQ7	ENTREZGENE
	G1FBS2_RAT	UniProtKB/TrEMBL
	Q9JMI9	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	F1LNQ7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Name	Description	Reference	Status
2004-09-10	Trpc3	transient receptor potential cation channel, subfamily C, member 3	transient receptor protein 3	Name updated	1299863	APPROVED
2002-06-10	Trpc3	transient receptor protein 3		Name updated	70584	APPROVED
2001-12-06	Trpc3	transient receptor protein 3		Symbol updated to reflect Human and Mouse nomenclature	69665	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_transcript	alternatively spliced form of a rat Trp3 exists which is designated Trp3sv	61774

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM