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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61973 Species: Rattus norvegicus RGD Object: Gene Symbol: Trpc3 Name: transient receptor potential cation channel, subfamily C, member 3

Acc ID: CHEBI:27732 Term: caffeine Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. CasRN: 58-08-2 Chemical ID: MESH:D002110

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:62266	6480464	CTD	TRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein]	PMID:16484216