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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61973 Species: Rattus norvegicus RGD Object: Gene Symbol: Trpc3 Name: transient receptor potential cation channel, subfamily C, member 3

Acc ID: CHEBI:8093 Term: phenylephrine Definition: A phenylethanolamine that has formula C9H13NO2. CasRN: 59-42-7 Chemical ID: MESH:D010656

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]	PMID:19244478
increases expression	EXP		6480464	CTD	Phenylephrine results in increased expression of TRPC3 protein Phenylephrine results in increased expression of TRPC3 mRNA	PMID:19244478
multiple interactions	EXP		6480464	CTD	TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]	PMID:15672411