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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:62266 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of TRPC3 mRNA | CTD | PMID:18648102 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of TRPC3 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of TRPC3 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | ISO | RGD:61973 | 6480464 | Ammonium Chloride affects the expression of TRPC3 mRNA | CTD | PMID:16483693 | barium(0) | multiple interactions | EXP | | 6480464 | 1-oleoyl-2-acetylglycerol promotes the reaction [TRPC3 protein results in increased transport of Barium] | CTD | PMID:11042129 | barium(0) | multiple interactions | ISO | RGD:62266 | 6480464 | 1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC3 protein results in increased transport of Barium] | CTD | PMID:16055711 | barium(0) | increases transport | ISO | RGD:62266 | 6480464 | TRPC3 protein results in increased transport of Barium | CTD | PMID:16055711 | barium(0) | increases transport | EXP | | 6480464 | TRPC3 protein results in increased transport of Barium | CTD | PMID:11042129 | benzo[a]pyrene | decreases expression | ISO | RGD:62266 | 6480464 | Benzo(a)pyrene results in decreased expression of TRPC3 mRNA | CTD | PMID:22228805 | caffeine | multiple interactions | ISO | RGD:62266 | 6480464 | TRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein] | CTD | PMID:16484216 | calcium atom | increases transport | EXP | | 6480464 | TRPC3 protein results in increased transport of Calcium | CTD | PMID:12736256 PMID:12700192 | calcium atom | increases transport | ISO | RGD:61973 | 6480464 | TRPC3 protein results in increased transport of Calcium | CTD | PMID:18822394 | calcium atom | multiple interactions | ISO | RGD:61973 | 6480464 | TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]; more ... | CTD | PMID:15672411 | calcium atom | affects transport | ISO | RGD:61973 | 6480464 | TRPC3 protein affects the transport of Calcium | CTD | PMID:15672411 | calcium atom | affects secretion | ISO | RGD:62266 | 6480464 | TRPC3 protein affects the secretion of Calcium | CTD | PMID:16484216 | calcium atom | multiple interactions | ISO | RGD:61973 | 6480464 | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium] | CTD | PMID:19244478 | calcium atom | increases transport | EXP | | 6480464 | TRPC3 protein results in increased transport of Calcium | CTD | PMID:12700192 PMID:12736256 | calcium atom | affects transport | EXP | | 6480464 | TRPC3 protein affects the transport of Calcium | CTD | PMID:17351372 | calcium atom | multiple interactions | EXP | | 6480464 | 1-oleoyl-2-acetylglycerol promotes the reaction [TRPC3 protein results in increased transport of Calcium]; more ... | CTD | PMID:12700192 | calcium atom | multiple interactions | EXP | | 6480464 | 1-oleoyl-2-acetylglycerol affects the reaction [TRPC3 protein affects the transport of Calcium] | CTD | PMID:17351372 | calcium(0) | increases transport | EXP | | 6480464 | TRPC3 protein results in increased transport of Calcium | CTD | PMID:12736256 PMID:12700192 | calcium(0) | increases transport | ISO | RGD:61973 | 6480464 | TRPC3 protein results in increased transport of Calcium | CTD | PMID:18822394 | calcium(0) | multiple interactions | ISO | RGD:61973 | 6480464 | TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]; more ... | CTD | PMID:15672411 | calcium(0) | affects transport | ISO | RGD:61973 | 6480464 | TRPC3 protein affects the transport of Calcium | CTD | PMID:15672411 | calcium(0) | affects secretion | ISO | RGD:62266 | 6480464 | TRPC3 protein affects the secretion of Calcium | CTD | PMID:16484216 | calcium(0) | multiple interactions | ISO | RGD:61973 | 6480464 | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium] | CTD | PMID:19244478 | calcium(0) | increases transport | EXP | | 6480464 | TRPC3 protein results in increased transport of Calcium | CTD | PMID:12700192 PMID:12736256 | calcium(0) | affects transport | EXP | | 6480464 | TRPC3 protein affects the transport of Calcium | CTD | PMID:17351372 | calcium(0) | multiple interactions | EXP | | 6480464 | 1-oleoyl-2-acetylglycerol promotes the reaction [TRPC3 protein results in increased transport of Calcium]; more ... | CTD | PMID:12700192 | calcium(0) | multiple interactions | EXP | | 6480464 | 1-oleoyl-2-acetylglycerol affects the reaction [TRPC3 protein affects the transport of Calcium] | CTD | PMID:17351372 | cyclosporin A | multiple interactions | ISO | RGD:61973 | 6480464 | Cyclosporine inhibits the reaction [Thapsigargin results in increased expression of TRPC3 mRNA] | CTD | PMID:19244478 | gadolinium atom | multiple interactions | EXP | | 6480464 | Gadolinium affects the localization of and results in decreased activity of TRPC3 protein | CTD | PMID:16522635 | paclitaxel | increases expression | EXP | | 6480464 | Paclitaxel results in increased expression of TRPC3 protein | CTD | PMID:15907983 | phenylephrine | multiple interactions | ISO | RGD:61973 | 6480464 | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium] | CTD | PMID:19244478 | phenylephrine | multiple interactions | ISO | RGD:61973 | 6480464 | TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium] | CTD | PMID:15672411 | phenylephrine | increases expression | ISO | RGD:61973 | 6480464 | Phenylephrine results in increased expression of TRPC3 protein; more ... | CTD | PMID:19244478 | phorbol 13-acetate 12-myristate | increases expression | ISO | RGD:61973 | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of TRPC3 mRNA | CTD | PMID:19244478 | thapsigargin | multiple interactions | EXP | | 6480464 | Thapsigargin promotes the reaction [TRPC3 protein results in increased transport of Calcium] | CTD | PMID:12700192 | thapsigargin | multiple interactions | ISO | RGD:61973 | 6480464 | Cyclosporine inhibits the reaction [Thapsigargin results in increased expression of TRPC3 mRNA] | CTD | PMID:19244478 | thapsigargin | increases expression | ISO | RGD:61973 | 6480464 | Thapsigargin results in increased expression of TRPC3 mRNA | CTD | PMID:19244478 | thapsigargin | multiple interactions | ISO | RGD:61973 | 6480464 | TRPC3 protein promotes the reaction [Thapsigargin results in increased transport of Calcium] | CTD | PMID:15672411 | trimellitic anhydride | decreases expression | ISO | RGD:62266 | 6480464 | trimellitic anhydride results in decreased expression of TRPC3 mRNA | CTD | PMID:19042947 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gamma (PID:200214) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gamma (PID:200214) |
References - curated| 1. |
GOA_HUMAN data from the GO Consortium |
| 2. |
RGD automated import pipeline for gene-chemical interactions |
| 3. |
Yu Y, etal., Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13861-6. Epub 2004 Sep 9. |
| 4. |
Zhu X, etal., Cell 1996 May 31;85(5):661-71. |
References - uncurated| PubMed | 10611319 |
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| 9930701 |
RGD Disease Portals| TRPC3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| TRPC3 (Homo sapiens) |
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| Trpc3 (Mus musculus) |
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| Trpc3 (Rattus norvegicus) |
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Position Markers| SHGC-51334 |
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| SHGC-149065 |
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| G01966 |
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| D4S956 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_030368 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001130698 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_003305 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AB255423 | (Get FASTA) | Search GEO for Microarray Profiles |
| AB255424 | (Get FASTA) | Search GEO for Microarray Profiles | |
| ABBA01044732 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC079341 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC108930 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01014492 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY865574 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC093682 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC093684 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC143239 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471056 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS105827 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X89068 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y13758 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001130698 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001124170 | ||||||||||||||||||||
| Peptide Label: | isoform a | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_003305 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_003296 | |||||||||||||||||||||||||
| Peptide Label: | isoform b | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001124170 | (Get FASTA) |
| NP_003296 | (Get FASTA) | |
| GenBank Protein | AAH93682 | (Get FASTA) |
| AAH93684 | (Get FASTA) | |
| AAW62292 | (Get FASTA) | |
| AAY40971 | (Get FASTA) | |
| BAF76423 | (Get FASTA) | |
| BAF76424 | (Get FASTA) | |
| CAA61448 | (Get FASTA) | |
| CAA74083 | (Get FASTA) | |
| CAJ01297 | (Get FASTA) | |
| EAX05243 | (Get FASTA) | |
| Q13507 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | TRPC3 | COSMIC |
| Ensembl Genes | ENSG00000138741 | ENTREZGENE |
| Ensembl Protein | ENSP00000264811 | ENTREZGENE |
| ENSP00000368966 | ENTREZGENE | |
| Ensembl Transcript | ENST00000264811 | ENTREZGENE |
| ENST00000379645 | ENTREZGENE | |
| Entrez Gene | 7222 | ENTREZGENE |
| Gene3D-CATH | ANK | UniProtKB/Swiss-Prot |
| Germonline | ENSG00000138741 | |
| HGNC ID | 12335 | ENTREZGENE |
| HomoloGene Group ID | 20708 | ENTREZGENE |
| HPRD ID | 15999 | ENTREZGENE |
| InterPro | Ankyrin_rpt | UniProtKB/Swiss-Prot |
| Ankyrin_rpt-contain_dom | UniProtKB/Swiss-Prot | |
| Ion_trans | UniProtKB/Swiss-Prot | |
| TRP_2 | UniProtKB/Swiss-Prot | |
| TRP_channel | UniProtKB/Swiss-Prot | |
| TRPC3_channel | UniProtKB/Swiss-Prot | |
| TRPC_channel | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:7222 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 602345 | OMIM |
| PANTHER | PTHR10117 | UniProtKB/Swiss-Prot |
| PTHR10117:SF8 | UniProtKB/Swiss-Prot | |
| Pfam | Ank | UniProtKB/Swiss-Prot |
| Ank_2 | UniProtKB/Swiss-Prot | |
| Ion_trans | UniProtKB/Swiss-Prot | |
| TRP_2 | UniProtKB/Swiss-Prot | |
| PharmGKB | PA37008 | PharmGKB |
| PRINTS | TRNSRECEPTRP | UniProtKB/Swiss-Prot |
| TRPCHANNEL3 | UniProtKB/Swiss-Prot | |
| PROSITE | ANK_REP_REGION | UniProtKB/Swiss-Prot |
| ANK_REPEAT; FALSE_NEG | UniProtKB/Swiss-Prot | |
| SMART | ANK | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | ANK | UniProtKB/Swiss-Prot |
| TIGRFAMs | Trp | UniProtKB/Swiss-Prot |
| UniGene | Hs.150981 | ENTREZGENE |
| UniProt | D6R902_HUMAN | UniProtKB/TrEMBL |
| D6RC49_HUMAN | UniProtKB/TrEMBL | |
| J3QTB0_HUMAN | UniProtKB/TrEMBL | |
| TRPC3_HUMAN | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-10-25 | TRPC3 | transient receptor potential cation channel, subfamily C, member 3 | TRPC3 | transient receptor potential cation channel, subfamily C, member 3 | Symbol and/or name change | 39860 | APPROVED |
| More on TRPC3 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 733864 |
| Created: | 2004-01-12 |
| Species: | Homo sapiens |
| Last Modified: | 2013-03-26 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




