Slc7a1 (solute carrier family 7 member 1) - Rat Genome Database

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Gene: Slc7a1 (solute carrier family 7 member 1) Rattus norvegicus
Analyze
Symbol: Slc7a1
Name: solute carrier family 7 member 1
RGD ID: 3716
Description: Enables L-arginine transmembrane transporter activity. Involved in L-arginine import across plasma membrane; L-arginine transmembrane transport; and regulation of TOR signaling. Located in apical plasma membrane and basal plasma membrane. Orthologous to human SLC7A1 (solute carrier family 7 member 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Atrc1; Cat-1; CAT1; cationic amino acid transporter, y+ system; cationinc amino acid transporter 1; EcoR; ecotropic retroviral leukemia receptor; ecotropic retrovirus receptor; ERR; high affinity cationic amino acid transporter 1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; Solute carrier family 7 member A1 (amino acid transporter cationic 1); solute carrier family 7, member 1; system Y+ basic amino acid transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,664,488 - 11,740,030 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1211,664,399 - 11,740,030 (+)EnsemblGRCr8
mRatBN7.2126,628,288 - 6,703,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,628,007 - 6,703,849 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx127,313,543 - 7,387,012 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,936,680 - 8,010,153 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,964,688 - 7,038,155 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0128,032,775 - 8,108,972 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl128,032,809 - 8,108,972 (+)Ensemblrn6Rnor6.0
Rnor_5.01210,119,575 - 10,192,908 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4127,230,519 - 7,253,858 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera128,375,860 - 8,449,856 (+)NCBICelera
RGSC_v3.1127,260,446 - 7,283,785 (+)NCBI
RH 3.4 Map1274.6RGD
Cytogenetic Map12p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-iodothyronamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
ibuprofen  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylephrine  (EXP)
phorone  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topiramate  (EXP)
topotecan  (EXP)
triazines  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular sites of regulation of expression of the rat cationic amino acid transporter gene. Aulak KS, etal., J Biol Chem 1996 Nov 22;271(47):29799-806.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Huang Y, etal., J Neurosci. 2007 Jan 17;27(3):449-58.
5. A glycosylation-defective variant of the ecotropic murine retrovirus receptor is expressed in rat XC cells. Kubo Y, etal., Virology 2002 Nov 25;303(2):338-44.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Developmental changes of l-arginine transport at the blood-brain barrier in rats. Tachikawa M, etal., Microvasc Res. 2018 May;117:16-21. doi: 10.1016/j.mvr.2017.12.003. Epub 2017 Dec 14.
13. Contribution of virus-receptor interaction to distinct viral proliferation of neuropathogenic and nonneuropathogenic murine leukemia viruses in rat glial cells. Takase-Yoden S and Watanabe R, J Virol 1999 May;73(5):4461-4.
14. Cationic amino acid transporter 1-mediated L-arginine transport at the inner blood-retinal barrier. Tomi M, etal., J Neurochem. 2009 Nov;111(3):716-25. doi: 10.1111/j.1471-4159.2009.06367.x. Epub 2009 Aug 27.
Additional References at PubMed
PMID:8195186   PMID:8385111   PMID:8473910   PMID:11114306   PMID:11877448   PMID:12757712   PMID:14523001   PMID:15849232   PMID:17042743   PMID:17178122   PMID:17197568   PMID:18552509  
PMID:19386725   PMID:19420114   PMID:19720825   PMID:19843630   PMID:19946888   PMID:25747984   PMID:28089735   PMID:28246125  


Genomics

Comparative Map Data
Slc7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,664,488 - 11,740,030 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1211,664,399 - 11,740,030 (+)EnsemblGRCr8
mRatBN7.2126,628,288 - 6,703,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,628,007 - 6,703,849 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx127,313,543 - 7,387,012 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,936,680 - 8,010,153 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,964,688 - 7,038,155 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0128,032,775 - 8,108,972 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl128,032,809 - 8,108,972 (+)Ensemblrn6Rnor6.0
Rnor_5.01210,119,575 - 10,192,908 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4127,230,519 - 7,253,858 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera128,375,860 - 8,449,856 (+)NCBICelera
RGSC_v3.1127,260,446 - 7,283,785 (+)NCBI
RH 3.4 Map1274.6RGD
Cytogenetic Map12p11NCBI
SLC7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381329,509,414 - 29,595,688 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1329,509,410 - 29,595,781 (-)Ensemblhg38GRCh38
GRCh371330,083,551 - 30,169,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361328,981,551 - 29,067,721 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341328,981,551 - 29,067,721NCBI
Celera1311,159,177 - 11,245,451 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1310,903,933 - 10,990,064 (-)NCBIHuRef
CHM1_11330,051,292 - 30,137,305 (-)NCBICHM1_1
T2T-CHM13v2.01328,732,320 - 28,818,340 (-)NCBIT2T-CHM13v2.0
Slc7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395148,264,220 - 148,336,714 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5148,264,220 - 148,336,714 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385148,327,410 - 148,399,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5148,327,410 - 148,399,904 (-)Ensemblmm10GRCm38
MGSCv375149,138,986 - 149,211,480 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365148,638,675 - 148,710,228 (-)NCBIMGSCv36mm8
Celera5146,326,464 - 146,400,567 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map588.48NCBI
Slc7a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543116,260,605 - 16,315,332 (+)Ensembl
ChiLan1.0NW_00495543116,270,648 - 16,315,280 (+)NCBIChiLan1.0ChiLan1.0
SLC7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21429,098,114 - 29,183,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11320,205,111 - 20,290,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01310,791,600 - 10,877,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11328,832,128 - 28,907,403 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1328,837,200 - 28,907,403 (-)EnsemblpanPan2panpan1.1
SLC7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12510,272,949 - 10,363,793 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2510,292,926 - 10,359,383 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2510,337,889 - 10,404,361 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02510,337,606 - 10,477,631 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2510,406,689 - 10,476,852 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12510,300,565 - 10,367,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02510,308,115 - 10,374,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02510,349,966 - 10,416,429 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc7a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945171,434,308 - 171,509,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647224,444,772 - 24,517,792 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647224,442,907 - 24,517,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,538,045 - 6,604,658 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1116,538,053 - 6,604,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,317,578 - 6,359,913 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap11pNCBI
SLC7A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.138,522,268 - 8,606,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl38,527,273 - 8,606,402 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605735,759,948 - 35,844,081 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247768,897,489 - 8,934,722 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247768,859,519 - 8,935,370 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc7a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1165,491,669 - 5,523,242 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc7a1
416 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:663
Count of miRNA genes:293
Interacting mature miRNAs:387
Transcripts:ENSRNOT00000001234
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
D12Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,701,277 - 6,701,595 (+)MAPPERmRatBN7.2
Rnor_6.0128,106,403 - 8,106,718NCBIRnor6.0
Rnor_5.01210,190,339 - 10,190,654UniSTSRnor5.0
RGSC_v3.4127,251,289 - 7,251,604UniSTSRGSC3.4
Celera128,447,287 - 8,447,602UniSTS
Cytogenetic Map12p11UniSTS
D12Got206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,684,210 - 6,684,370 (+)MAPPERmRatBN7.2
Rnor_6.0128,089,341 - 8,089,500NCBIRnor6.0
Rnor_5.01210,173,277 - 10,173,436UniSTSRnor5.0
RGSC_v3.4127,234,218 - 7,234,377UniSTSRGSC3.4
Celera128,430,260 - 8,430,401UniSTS
Cytogenetic Map12p11UniSTS
RH94683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,701,536 - 6,701,725 (+)MAPPERmRatBN7.2
Rnor_6.0128,106,660 - 8,106,848NCBIRnor6.0
Rnor_5.01210,190,596 - 10,190,784UniSTSRnor5.0
RGSC_v3.4127,251,546 - 7,251,734UniSTSRGSC3.4
Celera128,447,544 - 8,447,732UniSTS
RH 3.4 Map1274.6UniSTS
Cytogenetic Map12p11UniSTS
RH143690  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,702,776 - 6,702,885 (+)MAPPERmRatBN7.2
Rnor_6.0128,107,900 - 8,108,008NCBIRnor6.0
Rnor_5.01210,191,836 - 10,191,944UniSTSRnor5.0
RGSC_v3.4127,252,786 - 7,252,894UniSTSRGSC3.4
Celera128,448,784 - 8,448,892UniSTS
RH 3.4 Map1272.1UniSTS
Cytogenetic Map12p11UniSTS
BE113036  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,703,624 - 6,703,792 (+)MAPPERmRatBN7.2
Rnor_6.0128,108,748 - 8,108,915NCBIRnor6.0
Rnor_5.01210,192,684 - 10,192,851UniSTSRnor5.0
RGSC_v3.4127,253,634 - 7,253,801UniSTSRGSC3.4
Celera128,449,632 - 8,449,799UniSTS
RH 3.4 Map1274.7UniSTS
Cytogenetic Map12p11UniSTS
BI276254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,700,041 - 6,700,215 (+)MAPPERmRatBN7.2
Rnor_6.0128,105,167 - 8,105,340NCBIRnor6.0
Rnor_5.01210,189,103 - 10,189,276UniSTSRnor5.0
RGSC_v3.4127,250,053 - 7,250,226UniSTSRGSC3.4
Celera128,446,051 - 8,446,224UniSTS
RH 3.4 Map1270.3UniSTS
Cytogenetic Map12p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 355 192 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001234   ⟹   ENSRNOP00000001234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl128,085,525 - 8,108,972 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082850   ⟹   ENSRNOP00000072647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1211,664,399 - 11,740,030 (+)Ensembl
mRatBN7.2 Ensembl126,628,007 - 6,703,849 (+)Ensembl
Rnor_6.0 Ensembl128,032,809 - 8,106,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089804   ⟹   ENSRNOP00000075532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl128,085,525 - 8,108,532 (+)Ensembl
RefSeq Acc Id: NM_001399982   ⟹   NP_001386911
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,664,488 - 11,740,030 (+)NCBI
mRatBN7.2126,628,288 - 6,703,849 (+)NCBI
RefSeq Acc Id: XM_063271087   ⟹   XP_063127157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,679,641 - 11,740,030 (+)NCBI
Ensembl Acc Id: ENSRNOP00000072647   ⟸   ENSRNOT00000082850
Ensembl Acc Id: ENSRNOP00000075532   ⟸   ENSRNOT00000089804
Ensembl Acc Id: ENSRNOP00000001234   ⟸   ENSRNOT00000001234
RefSeq Acc Id: NP_001386911   ⟸   NM_001399982
- UniProtKB: P70608 (UniProtKB/TrEMBL),   Q8VIA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127157   ⟸   XM_063271087
- Peptide Label: isoform X1
- UniProtKB: P70608 (UniProtKB/TrEMBL),   Q8VIA9 (UniProtKB/TrEMBL)
Protein Domains
Cationic amino acid transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30823-F1-model_v2 AlphaFold P30823 1-624 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698399
Promoter ID:EPDNEW_R8921
Type:initiation region
Name:Slc7a1_1
Description:solute carrier family 7 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0128,032,851 - 8,032,911EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3716 AgrOrtholog
BioCyc Gene G2FUF-20134 BioCyc
Ensembl Genes ENSRNOG00000000924 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000082850 ENTREZGENE
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot
InterPro AA/rel_permease1 UniProtKB/Swiss-Prot
  Cat_AA_permease UniProtKB/Swiss-Prot
  CAT_C UniProtKB/Swiss-Prot
NCBI Gene 25648 ENTREZGENE
PANTHER HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1 UniProtKB/Swiss-Prot
  INNER MEMBRANE TRANSPORTER YGJI-RELATED UniProtKB/Swiss-Prot
Pfam AA_permease_2 UniProtKB/Swiss-Prot
  AA_permease_C UniProtKB/Swiss-Prot
PhenoGen Slc7a1 PhenoGen
PIRSF AA_transporter UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000924 RatGTEx
UniProt A0A0G2K3I1_RAT UniProtKB/TrEMBL
  CTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70608 ENTREZGENE, UniProtKB/TrEMBL
  Q3V5G8_RAT UniProtKB/TrEMBL
  Q8VIA9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc7a1  solute carrier family 7 member 1  Slc7a1  solute carrier family 7 (cationic amino acid transporter, y+ system), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc7a1  solute carrier family 7 (cationic amino acid transporter, y+ system), member 1    solute carrier family 7, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc7a1  solute carrier family 7, member 1    Solute carrier family 7 member A1 (amino acid transporter cationic 1)  Name updated 629478 APPROVED
2002-06-10 Slc7a1  Solute carrier family 7 member A1 (amino acid transporter cationic 1)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in regenerating liver 730128
gene_function receptor for ecotropic murine leukemia viruses; binds to Env protein 730156
gene_process required for transport of cationic amino acids and polyamines in liver cells during late G1 phase; function as a delayed early growth response gene in regenerating liver 730128
gene_protein protein is N-glycosylated 730156
gene_transcript alternatively polyadenylated to produce 7.9 kb and 3.4 kb transcripts 730128