SLC7A1 (solute carrier family 7 member 1) - Rat Genome Database

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Gene: SLC7A1 (solute carrier family 7 member 1) Sus scrofa
Analyze
Symbol: SLC7A1
Name: solute carrier family 7 member 1
RGD ID: 13956991
Description: ENCODES a protein that exhibits L-arginine transmembrane transporter activity (ortholog); INVOLVED IN L-arginine transmembrane transport (ortholog); positive regulation of T cell proliferation (ortholog); regulation of TOR signaling (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN basal plasma membrane (ortholog); INTERACTS WITH bisphenol A; deoxynivalenol; fumonisin B1
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CAT-1; cationic amino acid transporter-1; high affinity cationic amino acid transporter 1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,538,045 - 6,604,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,538,053 - 6,604,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,317,578 - 6,359,913 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap11pNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15718102   PMID:17145712   PMID:20412689   PMID:22301074   PMID:24222247   PMID:24368521   PMID:30032202   PMID:30236161  


Genomics

Comparative Map Data
SLC7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,538,045 - 6,604,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,538,053 - 6,604,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,317,578 - 6,359,913 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap11pNCBI
SLC7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381329,509,414 - 29,595,688 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1329,509,414 - 29,595,688 (-)EnsemblGRCh38hg38GRCh38
GRCh371330,083,551 - 30,169,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361328,981,551 - 29,067,721 (-)NCBINCBI36Build 36hg18NCBI36
Build 341328,981,551 - 29,067,721NCBI
Celera1311,159,177 - 11,245,451 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1310,903,933 - 10,990,064 (-)NCBIHuRef
CHM1_11330,051,292 - 30,137,305 (-)NCBICHM1_1
T2T-CHM13v2.01328,732,320 - 28,818,340 (-)NCBIT2T-CHM13v2.0
Slc7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395148,264,220 - 148,336,714 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5148,264,220 - 148,336,714 (-)EnsemblGRCm39 Ensembl
GRCm385148,327,410 - 148,399,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5148,327,410 - 148,399,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv375149,138,986 - 149,211,480 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365148,638,675 - 148,710,228 (-)NCBIMGSCv36mm8
Celera5146,326,464 - 146,400,567 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map588.48NCBI
Slc7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,664,488 - 11,740,030 (+)NCBIGRCr8
mRatBN7.2126,628,288 - 6,703,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,628,007 - 6,703,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx127,313,543 - 7,387,012 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,936,680 - 8,010,153 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,964,688 - 7,038,155 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0128,032,775 - 8,108,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl128,032,809 - 8,108,972 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,119,575 - 10,192,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,230,519 - 7,253,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,260,446 - 7,283,785 (+)NCBI
Celera128,375,860 - 8,449,856 (+)NCBICelera
RH 3.4 Map1274.6RGD
Cytogenetic Map12p11NCBI
Slc7a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543116,260,605 - 16,315,332 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543116,270,648 - 16,315,280 (+)NCBIChiLan1.0ChiLan1.0
SLC7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21429,098,114 - 29,183,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11320,205,111 - 20,290,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01310,791,600 - 10,877,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11328,832,128 - 28,907,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1328,837,200 - 28,907,403 (-)Ensemblpanpan1.1panPan2
SLC7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12510,272,949 - 10,363,793 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2510,292,926 - 10,359,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2510,337,889 - 10,404,361 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02510,337,606 - 10,477,631 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2510,406,689 - 10,476,852 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12510,300,565 - 10,367,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02510,308,115 - 10,374,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02510,349,966 - 10,416,429 (+)NCBIUU_Cfam_GSD_1.0
Slc7a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945171,434,308 - 171,509,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647224,444,772 - 24,517,792 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647224,442,907 - 24,517,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.138,522,268 - 8,606,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl38,527,273 - 8,606,402 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605735,759,948 - 35,844,081 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247768,897,489 - 8,934,722 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247768,859,519 - 8,935,370 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC7A1
2691 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 9 3 3 5 2 22 1 3 3
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010217   ⟹   ENSSSCP00000009951
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl116,538,045 - 6,604,658 (-)Ensembl
RefSeq Acc Id: NM_001012613   ⟹   NP_001012631
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,538,056 - 6,604,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021065162   ⟹   XP_020920821
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,538,053 - 6,604,377 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021065163   ⟹   XP_020920822
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,538,054 - 6,596,892 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021065164   ⟹   XP_020920823
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,538,054 - 6,596,822 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021065165   ⟹   XP_020920824
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1116,538,054 - 6,592,497 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020920821   ⟸   XM_021065162
- Peptide Label: isoform X1
- UniProtKB: A0A8D1WAE7 (UniProtKB/TrEMBL),   I3LTD9 (UniProtKB/TrEMBL),   F1RSU0 (UniProtKB/TrEMBL),   Q5DT24 (UniProtKB/TrEMBL),   A0A4X1TKW9 (UniProtKB/TrEMBL),   A0A8D0VS09 (UniProtKB/TrEMBL),   A0A8D1F2A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920822   ⟸   XM_021065163
- Peptide Label: isoform X1
- UniProtKB: A0A8D1WAE7 (UniProtKB/TrEMBL),   I3LTD9 (UniProtKB/TrEMBL),   F1RSU0 (UniProtKB/TrEMBL),   Q5DT24 (UniProtKB/TrEMBL),   A0A4X1TKW9 (UniProtKB/TrEMBL),   A0A8D0VS09 (UniProtKB/TrEMBL),   A0A8D1F2A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920823   ⟸   XM_021065164
- Peptide Label: isoform X1
- UniProtKB: A0A8D1WAE7 (UniProtKB/TrEMBL),   I3LTD9 (UniProtKB/TrEMBL),   F1RSU0 (UniProtKB/TrEMBL),   Q5DT24 (UniProtKB/TrEMBL),   A0A4X1TKW9 (UniProtKB/TrEMBL),   A0A8D0VS09 (UniProtKB/TrEMBL),   A0A8D1F2A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920824   ⟸   XM_021065165
- Peptide Label: isoform X1
- UniProtKB: A0A8D1WAE7 (UniProtKB/TrEMBL),   I3LTD9 (UniProtKB/TrEMBL),   F1RSU0 (UniProtKB/TrEMBL),   Q5DT24 (UniProtKB/TrEMBL),   A0A4X1TKW9 (UniProtKB/TrEMBL),   A0A8D0VS09 (UniProtKB/TrEMBL),   A0A8D1F2A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001012631   ⟸   NM_001012613
- UniProtKB: Q5DT24 (UniProtKB/TrEMBL),   A0A8D1WAE7 (UniProtKB/TrEMBL),   I3LTD9 (UniProtKB/TrEMBL),   F1RSU0 (UniProtKB/TrEMBL),   A0A4X1TKW9 (UniProtKB/TrEMBL),   A0A8D0VS09 (UniProtKB/TrEMBL),   A0A8D1F2A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009951   ⟸   ENSSSCT00000010217
Protein Domains
Cationic amino acid transporter C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029456 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025058858 UniProtKB/TrEMBL
  ENSSSCG00030016978 UniProtKB/TrEMBL
  ENSSSCG00035044594 UniProtKB/TrEMBL
  ENSSSCG00040050413 UniProtKB/TrEMBL
  ENSSSCG00045026330 UniProtKB/TrEMBL
  ENSSSCG00055009616 UniProtKB/TrEMBL
  ENSSSCG00060062688 UniProtKB/TrEMBL
  ENSSSCG00065049449 UniProtKB/TrEMBL
  ENSSSCG00070009720 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010217 ENTREZGENE
  ENSSSCT00000010217.5 UniProtKB/TrEMBL
  ENSSSCT00025080600.1 UniProtKB/TrEMBL
  ENSSSCT00025080860.1 UniProtKB/TrEMBL
  ENSSSCT00030023478.1 UniProtKB/TrEMBL
  ENSSSCT00035059234.1 UniProtKB/TrEMBL
  ENSSSCT00040068064.1 UniProtKB/TrEMBL
  ENSSSCT00045044818.1 UniProtKB/TrEMBL
  ENSSSCT00055018801.1 UniProtKB/TrEMBL
  ENSSSCT00060085528.1 UniProtKB/TrEMBL
  ENSSSCT00065067716.1 UniProtKB/TrEMBL
  ENSSSCT00070018871.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  Cat_AA_permease UniProtKB/TrEMBL
  CAT_C UniProtKB/TrEMBL
KEGG Report ssc:503545 UniProtKB/TrEMBL
NCBI Gene SLC7A1 ENTREZGENE
PANTHER HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1 UniProtKB/TrEMBL
  INNER MEMBRANE TRANSPORTER YGJI-RELATED UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
  AA_permease_C UniProtKB/TrEMBL
PIRSF AA_transporter UniProtKB/TrEMBL
UniProt A0A4X1TKW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0SQ10_PIG UniProtKB/TrEMBL
  A0A8D0VS09 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1F2A6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1WAE7 ENTREZGENE, UniProtKB/TrEMBL
  F1RSU0 ENTREZGENE
  I3LTD9 ENTREZGENE
  Q5DT24 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1RSU0 UniProtKB/TrEMBL
  I3LTD9 UniProtKB/TrEMBL
VGNC ID VGNC:93169 ENTREZGENE