RGD Reference Report - The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. - Rat Genome Database

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The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.

Authors: Huang, Y  Kang, BN  Tian, J  Liu, Y  Luo, HR  Hester, L  Snyder, SH 
Citation: Huang Y, etal., J Neurosci. 2007 Jan 17;27(3):449-58.
RGD ID: 1642930
Pubmed: PMID:17234578   (View Abstract at PubMed)
PMCID: PMC6672784   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.4489-06.2007   (Journal Full-text)

Neuronal activity influences protein synthesis and neuronal growth. Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth. We show that NMDA receptor activation markedly reduces arginine transport by decreasing surface expression of the cationic amino acid transporters (CAT) 1 and 3. Depletion of CAT1 and CAT3 by RNA interference blocks influences of NMDA receptor activation on the mTOR pathway and neuronal process formation. Thus, the CATs mediate influences of NMDA receptor activation on the mTOR pathway that regulates neuronal processes.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
L-arginine transmembrane transport  IMP 1642930; 1642930 RGD 
regulation of TOR signaling  IMP 1642930; 1642930 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
L-arginine transmembrane transporter activity  IDA 1642930; 1642930 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc7a1  (solute carrier family 7 member 1)
Slc7a3  (solute carrier family 7 member 3)


Additional Information