Psmb8 (proteasome 20S subunit beta 8) - Rat Genome Database

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Gene: Psmb8 (proteasome 20S subunit beta 8) Rattus norvegicus
Analyze
Symbol: Psmb8
Name: proteasome 20S subunit beta 8
RGD ID: 3426
Description: Predicted to enable endopeptidase activity. Predicted to be involved in fat cell differentiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within antigen processing and presentation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex and spermatoproteasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to human PSMB8 (proteasome 20S subunit beta 8); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: large multifunctional protease 7; Lmp7; LOC103690099; low molecular mass polypeptide 7; macropain subunit C13; MGC124945; multicatalytic endopeptidase complex subunit C13; proteasome (prosome macropain) subunit beta type 8 (low molecular mass polypeptide 7); proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome component C13; proteasome subunit beta 8; proteasome subunit beta type-8; proteasome subunit beta type-8-like; proteasome subunit beta-5i; proteosome (prosome macropain) subunit beta type 8 (large multifunctional protease 7); proteosome (prosome, macropain) subunit, beta type 8; Ring10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Pur27 Pur30
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,654,068 - 4,657,049 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,654,068 - 4,657,031 (-)EnsemblGRCr8
mRatBN7.2204,652,159 - 4,655,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,652,159 - 4,655,283 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,404,875 - 5,407,839 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,766,618 - 4,769,582 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,248,299 - 5,251,264 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,990,809 - 3,993,772 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)Ensemblrn6Rnor6.0
Rnor_5.0206,070,355 - 6,073,317 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0207,275,040 - 7,276,378 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,786,260 - 4,789,223 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,253,214 - 6,256,177 (-)NCBICelera
RGSC_v3.1204,786,490 - 4,789,389 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
Genipin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
ionomycin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketoconazole  (ISO)
lactacystin  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
Moniliformin  (ISO)
Monobutylphthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrrolidine dithiocarbamate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
sibutramine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sulforaphane  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. cDNA cloning of rat proteasome subunit RC1, a homologue of RING10 located in the human MHC class II region. Aki M, etal., FEBS Lett 1992 Apr 13;301(1):65-8.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15060004   PMID:15356141   PMID:16769238   PMID:16857966   PMID:17540904   PMID:19032866   PMID:20458337   PMID:20888554   PMID:21881205   PMID:23376485   PMID:23706739  
PMID:24586191   PMID:26524591   PMID:32255680  


Genomics

Comparative Map Data
Psmb8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,654,068 - 4,657,049 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,654,068 - 4,657,031 (-)EnsemblGRCr8
mRatBN7.2204,652,159 - 4,655,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,652,159 - 4,655,283 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,404,875 - 5,407,839 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,766,618 - 4,769,582 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,248,299 - 5,251,264 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,990,809 - 3,993,772 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)Ensemblrn6Rnor6.0
Rnor_5.0206,070,355 - 6,073,317 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0207,275,040 - 7,276,378 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,786,260 - 4,789,223 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,253,214 - 6,256,177 (-)NCBICelera
RGSC_v3.1204,786,490 - 4,789,389 (-)NCBI
Cytogenetic Map20p12NCBI
PSMB8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,840,717 - 32,844,679 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,840,717 - 32,844,679 (-)Ensemblhg38GRCh38
GRCh37632,808,494 - 32,812,456 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,916,472 - 32,920,690 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34632,916,472 - 32,919,792NCBI
Celera634,357,387 - 34,361,605 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,550,700 - 32,554,918 (-)NCBIHuRef
CHM1_1632,809,321 - 32,813,539 (-)NCBICHM1_1
T2T-CHM13v2.0632,662,092 - 32,666,054 (-)NCBIT2T-CHM13v2.0
Psmb8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,417,169 - 34,420,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,416,695 - 34,420,428 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381734,198,195 - 34,201,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,197,721 - 34,201,454 (+)Ensemblmm10GRCm38
MGSCv371734,335,140 - 34,338,399 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361733,808,611 - 33,811,478 (+)NCBIMGSCv36mm8
Celera1736,951,781 - 36,955,036 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Psmb8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,500,477 - 1,504,072 (-)Ensembl
ChiLan1.0NW_0049554371,500,477 - 1,504,072 (-)NCBIChiLan1.0ChiLan1.0
PSMB8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,315,792 - 47,319,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,187,339 - 43,191,304 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,410,172 - 32,414,136 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,525,681 - 33,529,897 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,525,681 - 33,529,897 (-)EnsemblpanPan2panpan1.1
PSMB8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,419,456 - 2,422,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,378,126 - 2,432,303 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha122,501,125 - 2,504,497 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0122,701,094 - 2,704,475 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,701,094 - 2,714,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,418,542 - 2,421,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,500,008 - 2,503,382 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,574,324 - 2,577,715 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psmb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,048,353 - 38,051,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,908,490 - 25,911,925 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,908,533 - 25,911,914 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMB8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,058,461 - 25,062,245 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1725,058,456 - 25,061,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,425,070 - 29,428,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMB8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,260,774 - 39,264,990 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,260,511 - 39,265,166 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604432,627,347 - 32,631,067 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmb8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,823,115 - 23,826,367 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475423,822,965 - 23,826,367 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Psmb8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1188,084,787 - 8,087,920 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psmb8
100 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:70
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000000528
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7175099Tcs2T cell selection QTL 2T cell selection trait (VT:0004917)expression2045059324695009Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH132773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,652,206 - 4,653,401 (-)MAPPERmRatBN7.2
mRatBN7.2204,652,206 - 4,653,401 (+)MAPPERmRatBN7.2
Rnor_6.0205,214,027 - 5,215,221NCBIRnor6.0
Rnor_6.0203,992,530 - 3,993,724NCBIRnor6.0
Rnor_5.0206,072,078 - 6,073,272UniSTSRnor5.0
Rnor_5.0207,275,088 - 7,276,282UniSTSRnor5.0
RGSC_v3.4204,786,308 - 4,787,502UniSTSRGSC3.4
Celera206,253,262 - 6,254,456UniSTS
RH 3.4 Map2072.0UniSTS
Cytogenetic Map20p12UniSTS
RH139398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,656,317 - 4,656,544 (-)MAPPERmRatBN7.2
Rnor_6.0203,989,387 - 3,989,613NCBIRnor6.0
Rnor_5.0206,068,935 - 6,069,161UniSTSRnor5.0
RGSC_v3.4204,790,419 - 4,790,645UniSTSRGSC3.4
Celera206,257,373 - 6,257,599UniSTS
RH 3.4 Map2064.6UniSTS
Cytogenetic Map20p12UniSTS
RH139868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,656,365 - 4,656,556 (-)MAPPERmRatBN7.2
Rnor_6.0203,989,375 - 3,989,565NCBIRnor6.0
Rnor_5.0206,068,923 - 6,069,113UniSTSRnor5.0
RGSC_v3.4204,790,467 - 4,790,657UniSTSRGSC3.4
Celera206,257,421 - 6,257,611UniSTS
RH 3.4 Map2060.7UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 156 91 90 59 92 59 6 353 190 11 135 80 92 31 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000528   ⟹   ENSRNOP00000000528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl204,654,068 - 4,657,031 (-)Ensembl
mRatBN7.2 Ensembl204,652,159 - 4,655,283 (-)Ensembl
Rnor_6.0 Ensembl203,990,820 - 3,993,769 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082047   ⟹   ENSRNOP00000073470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,652,972 - 4,653,435 (-)Ensembl
Rnor_6.0 Ensembl203,992,496 - 3,992,959 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,990,853 - 3,993,769 (+)Ensembl
RefSeq Acc Id: NM_080767   ⟹   NP_542945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,654,068 - 4,657,031 (-)NCBI
mRatBN7.2204,652,159 - 4,655,122 (-)NCBI
Rnor_6.0203,990,809 - 3,993,772 (+)NCBI
Rnor_5.0207,275,040 - 7,276,378 (-)NCBI
RGSC_v3.4204,786,260 - 4,789,223 (-)RGD
Celera206,253,214 - 6,256,177 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278961   ⟹   XP_063135031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,654,881 - 4,657,049 (-)NCBI
RefSeq Acc Id: NP_542945   ⟸   NM_080767
- UniProtKB: Q6MGA4 (UniProtKB/Swiss-Prot),   P28064 (UniProtKB/Swiss-Prot),   A0A023IMI6 (UniProtKB/TrEMBL),   A0A023IKD2 (UniProtKB/TrEMBL),   A0A023IM45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073470   ⟸   ENSRNOT00000082047
Ensembl Acc Id: ENSRNOP00000000528   ⟸   ENSRNOT00000000528
RefSeq Acc Id: XP_063135031   ⟸   XM_063278961
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28064-F1-model_v2 AlphaFold P28064 1-276 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701325
Promoter ID:EPDNEW_R11848
Type:initiation region
Name:Psmb8_1
Description:proteasome subunit beta 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,990,820 - 3,990,880EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3426 AgrOrtholog
BioCyc Gene G2FUF-4554 BioCyc
Ensembl Genes ENSRNOG00000000456 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000528 ENTREZGENE
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7387376 IMAGE-MGC_LOAD
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot
  Pept_T1A_subB UniProtKB/Swiss-Prot
  Proteasome_bsu_CS UniProtKB/Swiss-Prot
  Proteasome_sua/b UniProtKB/Swiss-Prot
  Proteasome_suB-type UniProtKB/Swiss-Prot
KEGG Report rno:24968 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124945 IMAGE-MGC_LOAD
NCBI Gene 24968 ENTREZGENE
PANTHER METALLOPROTEASE TLDD UniProtKB/Swiss-Prot
  PROTEASOME SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam Proteasome UniProtKB/Swiss-Prot
PhenoGen Psmb8 PhenoGen
PRINTS PROTEASOME UniProtKB/Swiss-Prot
PROSITE PROTEASOME_BETA_1 UniProtKB/Swiss-Prot
  PROTEASOME_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000456 RatGTEx
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot
UniProt A0A023IKD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A023IKI3_RAT UniProtKB/TrEMBL
  A0A023IM45 ENTREZGENE, UniProtKB/TrEMBL
  A0A023IMI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q0A4_RAT UniProtKB/TrEMBL
  A6JJE2_RAT UniProtKB/TrEMBL
  P28064 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6MGA4 ENTREZGENE
UniProt Secondary Q6MGA4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Psmb8  proteasome 20S subunit beta 8  LOC103690099  proteasome subunit beta type-8-like  Data merged from RGD:9409361 737654 PROVISIONAL
2019-09-13 Psmb8  proteasome 20S subunit beta 8  Psmb8  proteasome subunit beta 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-19 Psmb8  proteasome subunit beta 8  Psmb8  proteasome (prosome, macropain) subunit, beta type, 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690099  proteasome subunit beta type-8-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-04-04 Psmb8  proteasome (prosome, macropain) subunit, beta type, 8  Psmb8  proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Psmb8  proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)  Psmb8  proteosome (prosome, macropain) subunit, beta type 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psmb8  proteasome (prosome, macropain) subunit, beta type, 8 (low molecular mass polypeptide 7)      Symbol and Name status set to approved 70586 APPROVED
2001-06-20 Lmp7  Low molecular mass polypeptide 7      Symbol withdrawn, duplicate of Psmb8 (RGD:3246) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_mapping found in the major histocompatibility RT1 complex 1300431