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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3426
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psmb8
Name: proteasome 20S subunit beta 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psmb8decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of PSMB8 mRNAPMID:16054898 PMID:21215274
Psmb8multiple interactionsEXP 6480464CTDAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PSMB8 mRNA]PMID:21215274
Psmb8decreases expressionISOPSMB8 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PSMB8 mRNAPMID:19619570
Psmb8increases expressionISOPSMB8 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of PSMB8 mRNAPMID:20106945
Psmb8increases expressionISOPsmb8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of PSMB8 mRNAPMID:19933214
Psmb8multiple interactionsISOPSMB8 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PSMB8 mRNAPMID:19619570
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