GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Psmb8 | decreases expression | ISO | Psmb8 (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased expression of PSMB8 mRNA; Doxorubicin results in decreased expression of PSMB8 protein | PMID:25896364 | Psmb8 | increases expression | ISO | Psmb8 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of PSMB8 mRNA | PMID:27155237 | Psmb8 | multiple interactions | ISO | Psmb8 (Mus musculus) | 6480464 | CTD | Doxorubicin inhibits the reaction [IFNG protein results in increased expression of PSMB8 mRNA]; Doxorubicin inhibits the reaction [IFNG protein results in increased expression of PSMB8 protein]; PSMB8 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; PSMB8 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; PSMB8 protein inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; PSMB8 protein inhibits the reaction [Doxorubicin results in increased expression of MAP3K5 protein]; PSMB8 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein] | PMID:25896364 PMID:27155237 | | ||||||||||||||||||||||
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