Gene:	Psen1 ( Rattus norvegicus ) presenilin 1
Description:	anti-apopotic protein; protects neurons from apoptosis through interaction with proliferation-associated gene (PAG); human homolog mutated in most cases of early onset familial Alzheimer's disease
Synonyms:	MGC:91716; IMAGE:7098018;
ArrayIDs:	1368792_at; 6194756; 1376075_at; GE20560; 5883632; 6558176; D82363_s_at; rc_AI009495_at; 6418343; 6664176; 6032021; 6017845; 6166980; 5645080; A_43_P11957; 5846203; 6736699; 6131995; 6288956; 6211266; 6331329; 6449276;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PSEN1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Psen1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Psen1 genome assembly 3.1 6 107729188 - 107781021     Rat Celera Assembly 6 101152916 - 101200696     RGSC genome assembly v3.4 6 107725733 - 107777567     Cytogenetic 6 q31 Mus musculus Psen1 Mouse genome assembly build 36.1 12 85029513 - 85076149     Cytogenetic 12 12 D1 Homo sapiens PSEN1 human genome assembly 14 72684480 - 72755750     Human genome assembly build 36.2 14 72672932 - 72756862     Cytogenetic 14 q24.3   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference interacts with proliferation-associated gene (PAG) resulting in protection from neuronal apoptosis 1304239 Gene Ontology protein binding,  peptidase activity,  endopeptidase activity ...  (details...)
Biological Process	Gene Ontology thymus development,  heart looping,  heart development ...  (details...)
Cellular Component	Note Reference localized to the inner membrane of mitochondria 729648 Gene Ontology nucleus,  ciliary rootlet,  membrane raft ...  (details...)
Disease	Ontology Hemorrhage,  Cerebral Hemorrhage,  Cerebral Amyloid Angiopathy ...  (details...)
Phenotype	Ontology neonatal lethality,  increased apoptosis,  abnormal skeleton morphology ...  (details...)
Expression	Note Reference developmentally regulated in the retina 727595
Pathway	Ontology Notch signaling pathway,  Alzheimer disease pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: PSN IPI UNIPARC: UPI00001327D9 IPI KEGG Report: rno:29192 ENTREZGENE HomoloGene Group ID: 7186 ENTREZGENE Germonline: 3425 Pfam: Presenilin IPI KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 05010 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04330 ENTREZGENE InterPro: Peptidase_A22. IPI InterPro: Pept_A22A_PS1. IPI InterPro: Peptidase_A22A. IPI Ensembl Protein: ENSRNOP00000012495 IPI IPI: IPI00326970 IPI Entrez Gene: Psen1 ENTREZGENE IMAGE_CLONE: IMAGE:7098018 IMAGE-MGC_LOAD MGC_CLONE: MGC:91716 IMAGE-MGC_LOAD TIGR: TC235825 UniProt: PSN1_RAT IPI Ensembl Genes: ENSRNOG00000009110 IPI PANTHER: Peptidase_A22A IPI PANTHER: Pept_A22A_PS1 IPI PRINTS: PRESENILIN1. IPI PRINTS: PRESENILIN. IPI
Sequences	Nucleotide: NM_019163 Get FASTA Search GEO Profiles Nucleotide: D82363 Get FASTA Search GEO Profiles Nucleotide: CH473982 Get FASTA Search GEO Profiles Nucleotide: BC070887 Get FASTA Search GEO Profiles Nucleotide: D82578 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: EDL81455 Get FASTA Protein: P97887 Get FASTA Protein: EDL81456 Get FASTA Protein: BAA11575 Get FASTA Protein: BAA11564 Get FASTA Protein: AAH70887 Get FASTA Protein: EDL81457 Get FASTA Protein: NP_062036 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 44440
References
Curated References	23 references in RGD related to Psen1
Other References	19 other references at PubMed related to Psen1
Database Information
RGD ID	3425
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Psen1 presenilin 1 APPROVED Name updated 70584