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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psen1
Name: presenilin 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psen1decreases expressionISOPsen1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of PSEN1 mRNAPMID:12057914
Psen1increases expressionISOPsen1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of PSEN1 mRNAPMID:12057914
Psen1multiple interactionsISOPSEN1 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]PMID:28242320
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