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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psen1
Name: presenilin 1
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psen1increases uptakeISOPSEN1 (Homo sapiens)6480464CTDPSEN1 protein results in increased uptake of CopperPMID:21239495
Psen1increases uptakeISOPsen1 (Mus musculus)6480464CTDPSEN1 protein results in increased uptake of CopperPMID:21239495
Psen1multiple interactionsISOPsen1 (Mus musculus)6480464CTD[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased abundance of Copper; Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX1 protein]; Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein]PMID:23541064 PMID:25352456
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