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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psen1
Name: presenilin 1
Acc ID: CHEBI:35018
Term: trenbolone
Definition: A 3-oxo-Delta(4) steroid that is estra-4,9,11-triene carrying an oxo group at position 3 and a hydroxy group at position 17beta. It is a synthetic anabolic steroid used for muscle growth in livestock.
Chemical ID: MESH:D014204
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psen1decreases expressionEXP 6480464CTDTrenbolone Acetate analog results in decreased expression of PSEN1 proteinPMID:25461682
Psen1multiple interactionsEXP 6480464CTDFlutamide inhibits the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; fulvestrant inhibits the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; Testosterone affects the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]; trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]]PMID:25461682
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