Gene:	Prkaca ( Rattus norvegicus ) protein kinase, cAMP-dependent, catalytic, alpha
Description:	active catalytic subunit of protein kinase A; phosphorylates and activates transcription factors in response to elevated levels of cAMP; mediates phosphorylation and regulation of enzyme substrates involved in intermediary metabolism
Synonyms:	PKCA1; Protein kinase, cAMP-dependent, catalytic, alpha; Cs-PKA; cAMP-dependent protein kinase catalytic subunit C alpha;  (details...)
ArrayIDs:	5763736; 6308665; 5773724; 6076494; 6578619; 6103687; 1371578_at; 6323112; 6184782; 5948716; 6116002; X57986mRNA_r_at; A_44_P330332; 6156869; 6340889; 5694774; 5829581; 6086374; 6018001; 6242847; 6614177; X57986mRNA_s_at; 6376466; 5728803; 6252657; 5650140; 6701504; 6659076; A_43_P15764; 6186652; 6652235; 5669398; 6130700; 6196610; 6490544; 5941361; GE1144969; 6373914; 5846759; 6626070; 6726994; 5694498; 6381300; 6714922;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PRKACA     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Prkaca     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Prkaca Rat Celera Assembly 19 23704332 - 23726776     RGSC genome assembly v3.4 19 25841969 - 25864839     Cytogenetic 19 q11     genome assembly 3.1 19 25845620 - 25861927 Mus musculus Prkaca Mouse genome assembly build 36.1 8 86496887 - 86520338     Cytogenetic 8 8 C3 Homo sapiens PRKACA human genome assembly 19 14063508 - 14085992     Human genome assembly build 36.2 19 14063500 - 14089559     Cytogenetic 19 p13.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference phosphorylates serine and threonine contained within the motif RRX 724621 Gene Ontology protein kinase activity,  protein kinase binding,  nucleotide binding ...  (details...)
Biological Process	Gene Ontology hormone-mediated signaling,  regulation of synaptic transmission,  protein amino acid phosphorylation ...  (details...)
Cellular Component	Gene Ontology protein complex,  nucleus,  mitochondrion ...  (details...)
Disease	Ontology Heart Failure, Congestive,  Cardiomyopathy, Hypertrophic (details...)
Pathway	Ontology protein kinase A (PKA) signaling pathway,  mitogen activated protein kinase signaling pathway,  Wnt signaling pathway ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: S_TK_X IPI SMART: S_TKc IPI PROSITE: AGC_KINASE_CTER IPI PROSITE: PROTEIN_KINASE_ST IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ATP IPI UNIPARC: UPI0000170AC0 IPI UNIPARC: UPI00004EAD17 IPI UNIPARC: UPI00002502F0 IPI KEGG Report: rno:25636 ENTREZGENE HomoloGene Group ID: 121574 ENTREZGENE Germonline: 3389 Pfam: Pkinase IPI KEGG Pathway: 04270 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04020 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04540 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04340 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 04740 ENTREZGENE KEGG Pathway: 05020 ENTREZGENE KEGG Pathway: 04742 ENTREZGENE InterPro: Protein_kinase_ATP_BS. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Kinase-like_dom. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: AGC-kinase_C. IPI InterPro: Prot_kinase_cat_dom. IPI Ensembl Protein: ENSRNOP00000007281 IPI Ensembl Protein: ENSRNOP00000044732 IPI IPI: IPI00829427 IPI IPI: IPI00200013 IPI IPI: IPI00555215 IPI Entrez Gene: Prkaca ENTREZGENE IMAGE_CLONE: IMAGE:7314651 IMAGE-MGC_LOAD MGC_CLONE: MGC:156823 IMAGE-MGC_LOAD UniProt: KAPCA_RAT IPI UniProt: KAPCA_RAT IPI UniProt: A1L1M0_RAT IPI Ensembl Genes: ENSRNOG00000005257 IPI RatMap: 44373 ENTREZGENE Superfamily-SCOP: Kinase_like IPI
Sequences	Nucleotide: X57986 Get FASTA Search GEO Profiles Nucleotide: BC129128 Get FASTA Search GEO Profiles Nucleotide: AY375243 Get FASTA Search GEO Profiles Nucleotide: CH473972 Get FASTA Search GEO Profiles Nucleotide: NM_001100922 Get FASTA Search GEO Profiles Nucleotide: XM_001072411 Get FASTA Search GEO Profiles Nucleotide: XM_341661 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: P27791 Get FASTA Protein: CAA41052 Get FASTA Protein: AAI29129 Get FASTA Protein: AAQ81631 Get FASTA Protein: EDL92251 Get FASTA Protein: NP_001094392 Get FASTA Protein: XP_001072411 Get FASTA Protein: XP_341662 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 20
References
Curated References	19 references in RGD related to Prkaca
Other References	66 other references at PubMed related to Prkaca
Database Information
RGD ID	3389
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Prkaca protein kinase, cAMP-dependent, catalytic, alpha APPROVED Name updated 70584