Plcg2 (phospholipase C, gamma 2) - Rat Genome Database

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Gene: Plcg2 (phospholipase C, gamma 2) Rattus norvegicus
Analyze
Symbol: Plcg2
Name: phospholipase C, gamma 2
RGD ID: 3348
Description: Enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of cell cycle G1/S phase transition; and response to ATP. Predicted to be located in several cellular components, including cytosol; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in ruffle membrane. Human ortholog(s) of this gene implicated in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2); PARTICIPATES IN erythropoietin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; B cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-2; phospholipase C-gamma-2; phospholipase C-IV; PLC-gamma-2; PLC-IV
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81962,456,196 - 62,592,684 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1962,453,259 - 62,592,684 (+)EnsemblGRCr8
mRatBN7.21945,547,416 - 45,683,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1952,359,626 - 52,496,321 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01953,010,779 - 53,147,507 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01955,255,035 - 55,391,742 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01950,039,410 - 50,173,543 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)Ensemblrn6Rnor6.0
Rnor_5.01960,828,451 - 60,962,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41947,875,572 - 47,947,573 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1944,819,007 - 44,954,904 (+)NCBICelera
RGSC_v3.11947,880,452 - 47,952,454 (-)NCBI
RH 3.4 Map19609.8RGD
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
dehydroepiandrosterone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EHT 1864  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
Evodiamine  (ISO)
exemestane  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
GSK-J4  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
Harpagoside  (ISO)
Honokiol  (ISO)
ibrutinib  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury(1+)  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
starch  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of store-operated calcium channel activity  (ISO)
antifungal innate immune response  (ISO)
B cell activation  (ISO)
B cell differentiation  (ISO)
B cell receptor signaling pathway  (ISO)
calcium-mediated signaling  (ISO)
cell activation  (ISO)
cellular response to calcium ion  (ISO)
cellular response to lectin  (ISO)
cellular response to lipid  (ISO)
follicular B cell differentiation  (ISO)
inositol trisphosphate biosynthetic process  (ISO)
intracellular signal transduction  (IEA,IMP,ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
macrophage activation involved in immune response  (ISO)
negative regulation of programmed cell death  (ISO)
phosphatidylinositol biosynthetic process  (ISO,ISS)
phosphatidylinositol metabolic process  (IBA)
phosphatidylinositol-mediated signaling  (IBA)
phospholipid catabolic process  (IEA)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IMP)
positive regulation of cell cycle G1/S phase transition  (IDA)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of epithelial cell migration  (IBA)
positive regulation of gene expression  (IEA,IMP,ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-23 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of intracellular signal transduction  (IEA,IMP)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
regulation of calcineurin-NFAT signaling cascade  (ISO)
regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (ISO)
release of sequestered calcium ion into cytosol  (IBA,ISO,ISS)
response to ATP  (IDA)
response to axon injury  (ISO)
response to lipopolysaccharide  (ISO)
response to magnesium ion  (IDA)
response to yeast  (ISO)
signal transduction  (IEA)
stimulatory C-type lectin receptor signaling pathway  (ISO)
T cell receptor signaling pathway  (ISO)
toll-like receptor signaling pathway  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Translocation of phospholipase C-gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates. Atkinson TP and Yang Q, Cell Signal. 1996 Sep;8(6):461-5.
2. A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. Emori Y, etal., J Biol Chem 1989 Dec 25;264(36):21885-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. PLCG2 promotes hepatocyte proliferation in vitro via NF-κB and ERK pathway by targeting bcl2, myc and ccnd1. Ma D, etal., Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3786-3792. doi: 10.1080/21691401.2019.1669616.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Wang D, etal., Immunity 2000 Jul;13(1):25-35.
18. Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling. Watanabe D, etal., J Biol Chem. 2001 Oct 19;276(42):38595-601. Epub 2001 Aug 15.
Additional References at PubMed
PMID:8615781   PMID:9013981   PMID:10925250   PMID:11606584   PMID:12181444   PMID:12928432   PMID:15611229   PMID:15728238   PMID:20458337   PMID:20624904   PMID:22078883   PMID:27323081  
PMID:29236324   PMID:29430764  


Genomics

Comparative Map Data
Plcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81962,456,196 - 62,592,684 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1962,453,259 - 62,592,684 (+)EnsemblGRCr8
mRatBN7.21945,547,416 - 45,683,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1952,359,626 - 52,496,321 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01953,010,779 - 53,147,507 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01955,255,035 - 55,391,742 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01950,039,410 - 50,173,543 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)Ensemblrn6Rnor6.0
Rnor_5.01960,828,451 - 60,962,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41947,875,572 - 47,947,573 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1944,819,007 - 44,954,904 (+)NCBICelera
RGSC_v3.11947,880,452 - 47,952,454 (-)NCBI
RH 3.4 Map19609.8RGD
Cytogenetic Map19q12NCBI
PLCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,739,041 - 81,962,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1681,738,248 - 81,962,685 (+)Ensemblhg38GRCh38
GRCh371681,772,646 - 81,996,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,362,768 - 80,549,400 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341680,370,430 - 80,549,399NCBI
Celera1666,110,768 - 66,289,752 (+)NCBICelera
Cytogenetic Map16q23.3NCBI
HuRef1667,566,775 - 67,745,459 (+)NCBIHuRef
CHM1_11683,224,253 - 83,403,260 (+)NCBICHM1_1
T2T-CHM13v2.01687,801,375 - 88,026,424 (+)NCBIT2T-CHM13v2.0
Plcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398118,225,014 - 118,361,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8118,225,030 - 118,361,881 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388117,498,275 - 117,635,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,498,291 - 117,635,142 (+)Ensemblmm10GRCm38
MGSCv378120,022,191 - 120,159,042 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368120,384,268 - 120,521,119 (+)NCBIMGSCv36mm8
Celera8121,718,712 - 121,856,018 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map864.26NCBI
Plcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555224,358,233 - 4,468,986 (+)Ensembl
ChiLan1.0NW_0049555224,352,890 - 4,480,735 (+)NCBIChiLan1.0ChiLan1.0
PLCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21891,495,290 - 91,707,727 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11697,414,824 - 97,627,377 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01662,383,270 - 62,561,579 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11681,812,581 - 81,984,067 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,812,565 - 81,984,064 (+)EnsemblpanPan2panpan1.1
PLCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,054,683 - 70,233,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,059,255 - 70,207,049 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha570,073,218 - 70,247,127 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0570,363,993 - 70,538,197 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl570,363,980 - 70,511,911 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,306,712 - 70,480,652 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,142,563 - 70,316,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0570,619,680 - 70,793,735 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plcg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,211,918 - 30,340,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647529,248,516 - 29,377,206 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647529,248,533 - 29,377,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl66,433,153 - 6,603,060 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.166,433,146 - 6,603,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.266,994,243 - 7,071,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1567,209,268 - 67,394,865 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl567,215,459 - 67,398,990 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660478,436,871 - 8,625,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247465,682,666 - 5,821,855 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247465,678,057 - 5,824,663 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Plcg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11737,203,389 - 37,284,964 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:109
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000018678
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH94702  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21945,683,678 - 45,683,877 (+)MAPPERmRatBN7.2
Rnor_6.01950,173,292 - 50,173,490NCBIRnor6.0
Rnor_5.01960,962,390 - 60,962,588UniSTSRnor5.0
RGSC_v3.41947,875,625 - 47,875,823UniSTSRGSC3.4
Celera1944,954,653 - 44,954,851UniSTS
RH 3.4 Map19609.8UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000090165   ⟹   ENSRNOP00000069801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1962,456,196 - 62,592,684 (+)Ensembl
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)Ensembl
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133796   ⟹   ENSRNOP00000110417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1962,456,196 - 62,592,684 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134986   ⟹   ENSRNOP00000100939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1962,456,196 - 62,592,684 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149364   ⟹   ENSRNOP00000105629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1962,453,259 - 62,592,684 (+)Ensembl
RefSeq Acc Id: NM_017168   ⟹   NP_058864
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81962,456,196 - 62,592,684 (+)NCBI
mRatBN7.21945,547,416 - 45,683,930 (+)NCBI
Rnor_6.01950,039,425 - 50,173,543 (+)NCBI
Rnor_5.01960,828,451 - 60,962,641 (+)NCBI
RGSC_v3.41947,875,572 - 47,947,573 (-)RGD
Celera1944,819,007 - 44,954,904 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097673   ⟹   XP_038953601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81962,493,734 - 62,592,668 (+)NCBI
mRatBN7.21945,584,957 - 45,683,915 (+)NCBI
RefSeq Acc Id: NP_058864   ⟸   NM_017168
- UniProtKB: P24135 (UniProtKB/Swiss-Prot),   A0A0G2JWA2 (UniProtKB/TrEMBL),   A6IZH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069801   ⟸   ENSRNOT00000090165
RefSeq Acc Id: XP_038953601   ⟸   XM_039097673
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWA2 (UniProtKB/TrEMBL),   A6IZH5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105629   ⟸   ENSRNOT00000149364
Ensembl Acc Id: ENSRNOP00000110417   ⟸   ENSRNOT00000133796
Ensembl Acc Id: ENSRNOP00000100939   ⟸   ENSRNOT00000134986
Protein Domains
C2   PH   PI-PLC X-box   PI-PLC Y-box   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24135-F1-model_v2 AlphaFold P24135 1-1265 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3348 AgrOrtholog
BioCyc Gene G2FUF-5544 BioCyc
Ensembl Genes ENSRNOG00000051986 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090165 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.20.20.190 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PI-PLC_fam UniProtKB/Swiss-Prot
  PLC-gamma UniProtKB/Swiss-Prot
  PLC-gamma_C-SH2 UniProtKB/Swiss-Prot
  PLC-gamma_N-SH2 UniProtKB/Swiss-Prot
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  PLCG_EF-hand_2 UniProtKB/Swiss-Prot
  PLCgamma2_SH3 UniProtKB/Swiss-Prot
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:29337 UniProtKB/Swiss-Prot
NCBI Gene 29337 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot
  PTHR10336:SF25 UniProtKB/Swiss-Prot
Pfam EF-hand_PLCG2 UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
  PI-PLC-X UniProtKB/Swiss-Prot
  PI-PLC-Y UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PharmGKB PLCG2 RGD
PhenoGen Plcg2 PhenoGen
PIRSF PLC-gamma UniProtKB/Swiss-Prot
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot
  SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051986 RatGTEx
SMART PLCXc UniProtKB/Swiss-Prot
  PLCYc UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF51695 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
TIGR TC202295
UniProt A0A0G2JWA2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKZ1_RAT UniProtKB/TrEMBL
  A0ABK0LKZ3_RAT UniProtKB/TrEMBL
  A0ABK0LYQ6_RAT UniProtKB/TrEMBL
  A6IZH5 ENTREZGENE, UniProtKB/TrEMBL
  P24135 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Plcg2  phospholipase C, gamma 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in several tissues with high expression in spleen 69934