Plcg2 (phospholipase C gamma 2) - Rat Genome Database

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Pathways
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Gene: Plcg2 (phospholipase C gamma 2) Ictidomys tridecemlineatus
Analyze
Symbol: Plcg2
Name: phospholipase C gamma 2
RGD ID: 12737388
Description: ENCODES a protein that exhibits phosphatidylinositol phospholipase C activity (ortholog); INVOLVED IN follicular B cell differentiation (ortholog); inositol trisphosphate biosynthetic process (ortholog); negative regulation of programmed cell death (ortholog); PARTICIPATES IN erythropoietin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-Associated (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); FOUND IN plasma membrane (ortholog); ruffle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,211,918 - 30,340,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647529,248,516 - 29,377,206 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647529,248,533 - 29,377,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antifungal innate immune response  (IEA)
B cell differentiation  (IEA)
B cell receptor signaling pathway  (IEA)
calcium-mediated signaling  (IEA)
cell activation  (IEA)
cellular response to calcium ion  (IEA)
cellular response to lectin  (IEA)
cellular response to lipid  (IEA)
follicular B cell differentiation  (IEA,ISO)
inositol trisphosphate biosynthetic process  (IEA,ISO)
intracellular signal transduction  (IEA)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
lipopolysaccharide-mediated signaling pathway  (IEA)
macrophage activation involved in immune response  (IEA)
negative regulation of programmed cell death  (IEA,ISO)
phosphatidylinositol biosynthetic process  (IEA)
phosphatidylinositol-mediated signaling  (IEA)
phospholipid catabolic process  (IEA)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendritic cell cytokine production  (IEA)
positive regulation of epithelial cell migration  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of I-kappaB phosphorylation  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-2 production  (IEA)
positive regulation of interleukin-23 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of neuroinflammatory response  (IEA)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phagocytosis, engulfment  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of receptor internalization  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon production  (IEA)
programmed cell death  (IEA,ISO)
regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of lipid metabolic process  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IEA)
response to ATP  (ISO)
response to axon injury  (IEA)
response to lipopolysaccharide  (IEA,ISO)
response to magnesium ion  (ISO)
response to yeast  (IEA)
signal transduction  (IEA)
stimulatory C-type lectin receptor signaling pathway  (IEA)
T cell receptor signaling pathway  (IEA,ISO)
toll-like receptor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Plcg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,211,918 - 30,340,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647529,248,516 - 29,377,206 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647529,248,533 - 29,377,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,779,291 - 81,962,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1681,779,279 - 81,962,685 (+)EnsemblGRCh38hg38GRCh38
GRCh371681,812,896 - 81,996,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,362,768 - 80,549,400 (+)NCBINCBI36Build 36hg18NCBI36
Build 341680,370,430 - 80,549,399NCBI
Celera1666,110,768 - 66,289,752 (+)NCBICelera
Cytogenetic Map16q23.3NCBI
HuRef1667,566,775 - 67,745,459 (+)NCBIHuRef
CHM1_11683,224,253 - 83,403,260 (+)NCBICHM1_1
T2T-CHM13v2.01687,843,143 - 88,026,424 (+)NCBIT2T-CHM13v2.0
Plcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398118,225,014 - 118,361,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8118,225,030 - 118,361,881 (+)EnsemblGRCm39 Ensembl
GRCm388117,498,275 - 117,635,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,498,291 - 117,635,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv378120,022,191 - 120,159,042 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368120,384,268 - 120,521,119 (+)NCBIMGSCv36mm8
Celera8121,718,712 - 121,856,018 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map864.26NCBI
Plcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81962,456,196 - 62,592,684 (+)NCBIGRCr8
mRatBN7.21945,547,416 - 45,683,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1952,359,626 - 52,496,321 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01953,010,779 - 53,147,507 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01955,255,035 - 55,391,742 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01950,039,410 - 50,173,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,828,451 - 60,962,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,875,572 - 47,947,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,880,452 - 47,952,454 (-)NCBI
Celera1944,819,007 - 44,954,904 (+)NCBICelera
RH 3.4 Map19609.8RGD
Cytogenetic Map19q12NCBI
Plcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555224,358,233 - 4,468,986 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555224,352,890 - 4,480,735 (+)NCBIChiLan1.0ChiLan1.0
PLCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21891,495,290 - 91,707,727 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11697,414,824 - 97,627,377 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01662,383,270 - 62,561,579 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11681,812,581 - 81,984,067 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,812,565 - 81,984,064 (+)Ensemblpanpan1.1panPan2
PLCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,054,683 - 70,233,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,059,255 - 70,207,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha570,073,218 - 70,247,127 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0570,363,993 - 70,538,197 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl570,363,980 - 70,511,911 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,306,712 - 70,480,652 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,142,563 - 70,316,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0570,619,680 - 70,793,735 (-)NCBIUU_Cfam_GSD_1.0
PLCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl66,433,153 - 6,603,060 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.166,433,146 - 6,603,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.266,994,243 - 7,071,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1567,209,268 - 67,394,865 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl567,215,459 - 67,398,990 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660478,436,871 - 8,625,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247465,682,666 - 5,821,855 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247465,678,057 - 5,824,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005318465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010004409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000005786   ⟹   ENSSTOP00000005174
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647529,248,516 - 29,377,206 (+)Ensembl
RefSeq Acc Id: XM_005318465   ⟹   XP_005318522
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934930,211,918 - 30,340,596 (-)NCBI
SpeTri2.0NW_00493647529,248,533 - 29,377,335 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005318522 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000005174.3
GenBank Protein KAG3256779 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005318522   ⟸   XM_005318465
- UniProtKB: I3M6N8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000005174   ⟸   ENSSTOT00000005786
Protein Domains
C2   PH   PI-PLC Y-box   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005756 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005786.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-gamma UniProtKB/TrEMBL
  PLC-gamma_C-SH2 UniProtKB/TrEMBL
  PLC-gamma_N-SH2 UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLCgamma2_SH3 UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene Plcg2 ENTREZGENE
PANTHER PTHR10336 UniProtKB/TrEMBL
  PTHR10336:SF25 UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PH_12 UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PIRSF PLC-gamma UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART PLCXc UniProtKB/TrEMBL
  PLCYc UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt I3M6N8 ENTREZGENE, UniProtKB/TrEMBL