RGD Reference Report - Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. - Rat Genome Database

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Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors.

Authors: Wang, D  Feng, J  Wen, R  Marine, JC  Sangster, MY  Parganas, E  Hoffmeyer, A  Jackson, CW  Cleveland, JL  Murray, PJ  Ihle, JN 
Citation: Wang D, etal., Immunity 2000 Jul;13(1):25-35.
RGD ID: 1302581
Pubmed: PMID:10933392   (View Abstract at PubMed)

Many receptors activate phospholipase Cgamma1 or -gamma2. To assess the role of PLCgamma2, we derived enzyme-deficient mice. The mice are viable but have decreased mature B cells, a block in pro-B cell differentiation, and B1 B cell deficiency. IgM receptor-induced Ca2+ flux and proliferation to B cell mitogens are absent. IgM, IgG2a, and IgG3 levels are reduced, and T cell-independent antibody production is absent. The similarity to Btk- or Blnk-deficient mice demonstrates that PLCgamma2 is downstream in Btk/Blnk signaling. FcRgamma signaling is also defective, resulting in a loss of collagen-induced platelet aggregation, mast cell FcepsilonR function, and NK cell FcgammaRIII and 2B4 function. The results define a signal transduction pathway broadly utilized by immunoglobulin superfamily receptors.

Objects referenced in this article
Gene PLCG2 phospholipase C gamma 2 Homo sapiens
Gene Plcg2 phospholipase C, gamma 2 Mus musculus
Gene Plcg2 phospholipase C, gamma 2 Rattus norvegicus

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