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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3348
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plcg2
Name: phospholipase C, gamma 2
Acc ID: CHEBI:76612
Term: ibrutinib
Definition: A member of the class of acrylamides that is (3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine in which the piperidine nitrogen is replaced by an acryloyl group. A selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase, it is used for treatment of B-cell malignancies.
Chemical ID: MESH:C551803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plcg2decreases phosphorylationISOPLCG2 (Homo sapiens)6480464CTDibrutinib results in decreased phosphorylation of PLCG2 proteinPMID:26254443
Plcg2decreases response to substanceISOPLCG2 (Homo sapiens)6480464CTDPLCG2 protein mutant form results in decreased susceptibility to ibrutinibPMID:27542411
Plcg2multiple interactionsISOPLCG2 (Homo sapiens)6480464CTD(+)-JQ1 compound promotes the reaction [ibrutinib results in decreased phosphorylation of PLCG2 protein]; ibrutinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of PLCG2 protein]PMID:26254443
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