Plcb1 Rat Gene (phospholipase C, beta 1 (phosphoinositide-specific))

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene:
Plcb1 ( Rattus norvegicus )
phospholipase C, beta 1 (phosphoinositide-specific)
Description: involved in serotonergic signaling via 5-HT(2) receptor modulation and activation of L-type Ca(2+) in prefrontal neurons; may contribute to etiology of schizophrenia
Synonyms: PLCbeta1; PLC'1; Phospholipase C-beta1; RATPHOSPHB; phospholipase C, beta 1; Phosphb;
ArrayIDs: 6097449; 5992749; 5921672; 5886195; 6045140; M20636_s_at; 6269437; 6421982; 6717531; 5637298; 6084555; 6641675; 6485672; 6511746; 5834181; 5661253; 6746431; 5921882; 6502712; 6171140; 5737136; 5974098; 6573383; 6463488; 5867902; 5652247; 5631202; 1371014_at; L14323_at; 6239229; 6744638; 5951458; 6311719; 5959396; A_44_P199211; 6596216; 5870407; 5821372; 6510771;  (details...)
Gene Type: protein-coding

Additional Data

Markers: D3Wox22

Homologs
Homo sapiens: PLCB1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Plcb1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Plcb1 RGSC genome assembly v3.4 3 122797846 - 123525301
Cytogenetic 3 q36
genome assembly 3.1 3 122703321 - 123430863
Rat Celera Assembly 3 121427075 - 121511905
Mus musculus Plcb1 Mouse genome assembly build 36.1 2 134612266 - 135298158
Cytogenetic 2 2 F3
Homo sapiens PLCB1 human genome assembly 20 8061295 - 8813547
Human genome assembly build 36.2 20 8061296 - 8813547
Cytogenetic 20 p12

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Other Map Data:
Associated SSLP Map Locations
No mapping information currently available in RGD for D3Wox22

Annotation
Molecular Function

Gene Ontology

signal transducer activity,  protein homodimerization activity,  calcium ion binding ... (details...)
Biological Process

Note Reference

may play a role in myoblast differentiation 1299010

Gene Ontology

learning,  phosphoinositide metabolic process,  oxygen and reactive oxygen species metabolic process ... (details...)
Cellular Component

Gene Ontology

cytoplasm,  membrane,  membrane fraction ... (details...)
Disease

Note Reference

inhibition of pathway modulated by 5-HT(2) receptor activation via atypical neuroleptics may lead to alterations in serotonergic signaling and schizophrenia 633577

Ontology

Myocardial Infarction,  Cardiomegaly (details...)
Phenotype

Ontology

abnormal depression-related behavior (details...)
Expression

Note Reference

expression levels significantly reduced in old neuronal striata 1299009

expressed in brain 1299007

Pathway

Note Reference

mediates intracellular Ca(2+), activation of calcineurin and inhibition of Ca(v)1.2 L-type Ca(2+) currents via upstream stimulation of 5-HT(2) receptors in prefrontal neurons 633577

may be involved in oxidative stress pathways 1299008

Ontology

inositol metabolic pathway,  valine, leucine and isoleucine degradation pathway,  propanoate metabolic pathway (details...)
Transcript structure

Note Reference

produced by alternative splicing of 5.4 kb transcript precursor 1299007

External Links
Databases
DATABASE ID SOURCE
SMART: PLCYc IPI
SMART: PLCXc IPI
SMART: C2 IPI
PROSITE: PIPLC_Y_DOMAIN IPI
PROSITE: C2 IPI
PROSITE: PIPLC_X_DOMAIN IPI
UNIPARC: UPI0001B7B34A IPI
UNIPARC: UPI0000DA2460 IPI
UNIPARC: UPI0000131A90 IPI
KEGG Report: rno:24654 ENTREZGENE
HomoloGene Group ID: 22876 ENTREZGENE
Germonline: 3344
Pfam: PLC-beta_C IPI
Pfam: PI-PLC-Y IPI
Pfam: PI-PLC-X IPI
Pfam: C2 IPI
Pfam: efhand_like IPI
KEGG Pathway: 04310 ENTREZGENE
KEGG Pathway: 04270 ENTREZGENE
KEGG Pathway: 04070 ENTREZGENE
KEGG Pathway: 01100 ENTREZGENE
KEGG Pathway: 04916 ENTREZGENE
KEGG Pathway: 04720 ENTREZGENE
KEGG Pathway: 04730 ENTREZGENE
KEGG Pathway: 00562 ENTREZGENE
KEGG Pathway: 05016 ENTREZGENE
KEGG Pathway: 04912 ENTREZGENE
KEGG Pathway: 04540 ENTREZGENE
KEGG Pathway: 04062 ENTREZGENE
KEGG Pathway: 04020 ENTREZGENE
KEGG Pathway: 05010 ENTREZGENE
InterPro: PLC-like_Pdiesterase_TIM-brl. IPI
InterPro: PLC-beta_C. IPI
InterPro: C2_Ca-dep. IPI
InterPro: C2_Ca/lipid-bd_reg_CaLB. IPI
InterPro: C2_membr_targeting. IPI
InterPro: EF-Hand_type. IPI
InterPro: Phospholipase_C_EF-hand-like. IPI
InterPro: Phospholipase_C_Pinositol-sp_C. IPI
InterPro: Phospholipase_C_Pinositol-sp_X. IPI
InterPro: Phospholipase_C_Pinositol-sp_Y. IPI
InterPro: PLC-beta. IPI
Ensembl Protein: ENSRNOP00000006389 IPI
Ensembl Protein: ENSRNOP00000042533 IPI
IPI: IPI00767945 IPI
IPI: IPI00192534 IPI
IPI: IPI00558422 IPI
Gene3D-CATH: PLC-like_Pdiesterase_TIM-brl IPI
Gene3D-CATH: EF-Hand_type IPI
Entrez Gene: Plcb1 ENTREZGENE
PIRSF: PLC-beta IPI
UniProt: PLCB1_RAT IPI
Ensembl Genes: ENSRNOG00000004810 IPI
RatMap: 34298 ENTREZGENE
Superfamily-SCOP: PLC-like_Pdiesterase_TIM-brl IPI
Superfamily-SCOP: C2_CaLB IPI
PRINTS: PHPHLIPASEC. IPI
Sequences
Nucleotide: L14323 Get FASTA Search GEO Profiles
Nucleotide: M20636 Get FASTA Search GEO Profiles
Nucleotide: XM_342524 Get FASTA Search GEO Profiles
Nucleotide: L14322 Get FASTA Search GEO Profiles
Nucleotide: XM_001081270 Get FASTA Search GEO Profiles
Nucleotide: CH473949 Get FASTA Search GEO Profiles
Nucleotide: NM_001077641 Get FASTA Search GEO Profiles
(View all 7 Nucleotide Accessions)
Protein: EDL80287 Get FASTA
Protein: NP_001071109 Get FASTA
Protein: P10687 Get FASTA
Protein: AAA41885 Get FASTA
Protein: XP_001081270 Get FASTA
Protein: XP_342525 Get FASTA
(View all 6 Protein Accessions)
Clusters
UniGene: 45523

References
Curated References
15 references in RGD related to Plcb1

Other References
19 other references at PubMed related to Plcb1

Database Information
RGD ID 3344
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

09-SEP-08: Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) Plcb1 phospholipase C, beta 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

09-JAN-08: Plcb1 phospholipase C, beta 1 LOC688139 similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154) APPROVED Data Merged 1643240

20-NOV-06: LOC688139 similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154) PROVISIONAL Symbol and Name status set to provisional 70820

10-JUN-02: Plcb1 Phospholipase C-beta1 APPROVED Symbol and Name status set to approved 70586