Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plcb1
Name: phospholipase C beta 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plcb1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PLCB1 mRNAPMID:25181051 PMID:30816183 PMID:34947998
Plcb1increases expressionEXP 6480464CTDbisphenol A results in increased expression of PLCB1 mRNAPMID:32145629
Plcb1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of PLCB1 genePMID:28505145
Plcb1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Testosterone] results in increased expression of PLCB1 mRNAPMID:26496021
Plcb1decreases expressionISOPlcb1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of PLCB1 mRNAPMID:26063408
Plcb1decreases methylationISOPLCB1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of PLCB1 genePMID:31601247
Plcb1increases expressionISOPLCB1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of PLCB1 mRNAPMID:36828454
Plcb1multiple interactionsISOPLCB1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of PLCB1 gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PLCB1 mRNAPMID:28628672 PMID:31601247
Go Back to source page   Continue to Ontology report