Pkm2 Rat Gene (pyruvate kinase, muscle)

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Keyword

Gene:
Pkm2 ( Rattus norvegicus )
pyruvate kinase, muscle
Description: an enzyme exhibiting pyruvate kinase activity, ATP binding, protein binding (Oct-3; mouse ortholog) and other inferred functions; involved in glycolysis, ATP biosynthetic process, organ regeneration and other processes; found in soluble fraction, nucleus (human ortholog), mitochondrion (mouse ortholog) and other locations (orthologs); part of glycolysis pathway, glycolysis/gluconeogenesis pathway (inferred), purine metabolic pathway (inferred) and other inferred pathways
Synonyms: Pyruvate kinase muscle; PKM12; Pk3;  (details...)
ArrayIDs: 6670145; 5626709; rc_AA998722_s_at; 5831479; 6470112; 5966093; 6740752; 6479886; 1369931_at; 6105104; 6378229; 5926478; rc_AA818951_at; GE1298142; 5700873; 5926839; 5675222; 6641752; 6558213; 5819675; 6460047; 6693194; 5981152; 6572105; 6435325; 6427343; 6377483; 6245265; 5845358; 6356722; 6270519; A_44_P818668; A_44_P410062; 5917385; 6501411; 6485962; 6732020; 6061139; 5769571; A_43_P12756; 5927914; 6692280; GE22114; 6329029; 6719797;  (details...)
Gene Type: protein-coding

Additional Data

Curated Variants: Pkm2_v1
Pkm2_v2

primer pair: 635189

Homologs
Homo sapiens: PKM2     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Pkm2     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Pkm2 genome assembly 3.1 8 63505545 - 63527070
Rat Celera Assembly 8 59500835 - 59522361
RH 3.4 8 703.1
RGSC genome assembly v3.4 8 63486490 - 63508016
Cytogenetic 8 q24
Mus musculus Pkm2 Mouse genome assembly build 36.1 9 59504415 - 59527182
Cytogenetic 9 9 B
Homo sapiens PKM2 human genome assembly 15 70278423 - 70310738
Human genome assembly build 36.2 15 70278424 - 70310738
Cytogenetic 15 q22

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Gene Ontology

protein binding,  pyruvate kinase activity,  potassium ion binding ... (details...)
Biological Process

Gene Ontology

response to organic substance,  response to gravity,  glycolysis ... (details...)
Cellular Component

Gene Ontology

nucleus,  mitochondrion,  flagellum ... (details...)
Expression

Note Reference

M1 isoform replaces M2 during development in skeletal muscle, heart, and brain 633549

Pathway

Ontology

glycolysis/gluconeogenesis pathway,  carbon fixation pathway,  pyruvate metabolic pathway ... (details...)

External Links
Databases
DATABASE ID SOURCE
PROSITE: PYRUVATE_KINASE IPI
UNIPARC: UPI0000047299 IPI
UNIPARC: UPI0000047298 IPI
UNIPARC: UPI0001B7AA5F IPI
KEGG Report: rno:25630 ENTREZGENE
HomoloGene Group ID: 37650 ENTREZGENE
Germonline: 3337
Pfam: PK IPI
Pfam: PK_C IPI
KEGG Pathway: 04930 ENTREZGENE
KEGG Pathway: 00620 ENTREZGENE
KEGG Pathway: 00230 ENTREZGENE
KEGG Pathway: 01100 ENTREZGENE
KEGG Pathway: 00010 ENTREZGENE
KEGG Pathway: 00710 ENTREZGENE
KEGG Pathway: 01062 ENTREZGENE
KEGG Pathway: 01070 ENTREZGENE
KEGG Pathway: 01061 ENTREZGENE
KEGG Pathway: 01066 ENTREZGENE
KEGG Pathway: 01063 ENTREZGENE
KEGG Pathway: 01064 ENTREZGENE
KEGG Pathway: 01065 ENTREZGENE
InterPro: Pyr_Knase. IPI
InterPro: Pyrv/PenolPyrv_Kinase_cat. IPI
InterPro: Pyrv_Knase_brl. IPI
InterPro: Pyrv_Knase_b-brl-like. IPI
InterPro: Pyrv_Knase_C-like. IPI
InterPro: Pyrv_Knase_AS. IPI
InterPro: Pyrv_Knase_a/b. IPI
Ensembl Protein: ENSRNOP00000015331 IPI
Ensembl Protein: ENSRNOP00000060594 IPI
Ensembl Protein: ENSRNOP00000015398 IPI
IPI: IPI00339197 IPI
IPI: IPI00454375 IPI
IPI: IPI00231929 IPI
Gene3D-CATH: Pyrv/PenolPyrv_Kinase_cat IPI
Gene3D-CATH: Pyrv_Knase_a/b IPI
Entrez Gene: Pkm2 ENTREZGENE
IMAGE_CLONE: IMAGE:6888187 IMAGE-MGC_LOAD
MGC_CLONE: MGC:72751 IMAGE-MGC_LOAD
Ensembl Genes: ENSRNOG00000011329 IPI
TIGR: TC204002
TIGR: TC204001
UniProt: KPYM_RAT IPI
UniProt: Q6P7S0_RAT IPI
UniProt: KPYM_RAT IPI
Superfamily-SCOP: Pyrv/PenolPyrv_Kinase_cat IPI
Superfamily-SCOP: Pyruvate_kinase IPI
Superfamily-SCOP: PK_B_barrel_like IPI
RatMap: 44367 ENTREZGENE
PANTHER: Pyruvate_kinase IPI
TIGRFAMs: pyruv_kin IPI
PRINTS: PYRUVTKNASE. IPI
Sequences
Nucleotide: M14377 Get FASTA Search GEO Profiles
Nucleotide: BC061541 Get FASTA Search GEO Profiles
Nucleotide: CH473975 Get FASTA Search GEO Profiles
Nucleotide: X15800 Get FASTA Search GEO Profiles
Nucleotide: NM_053297 Get FASTA Search GEO Profiles
Nucleotide: M24359 Get FASTA Search GEO Profiles
Nucleotide: AY724474 Get FASTA Search GEO Profiles
(View all 7 Nucleotide Accessions)
Protein: EDL95705 Get FASTA
Protein: AAH61541 Get FASTA
Protein: NP_445749 Get FASTA
Protein: CAA33799 Get FASTA
Protein: AAB93666 Get FASTA
Protein: Q6P7S0 Get FASTA
Protein: P11980 Get FASTA
(View all 7 Protein Accessions)
Clusters
UniGene: 1556

References
Curated References
21 references in RGD related to Pkm2

Other References
22 other references at PubMed related to Pkm2

Database Information
RGD ID 3337
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

06-NOV-02: Pkm2 pyruvate kinase, muscle Pyruvate kinase, muscle APPROVED Name updated 625702

10-JUN-02: Pkm2 Pyruvate kinase, muscle APPROVED Symbol and Name status set to approved 70586