Oxtr (oxytocin receptor) - Rat Genome Database

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Gene: Oxtr (oxytocin receptor) Rattus norvegicus
Analyze
Symbol: Oxtr
Name: oxytocin receptor
RGD ID: 3239
Description: Enables oxytocin receptor activity and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; estrous cycle; and positive regulation of synaptic transmission. Located in adherens junction; apical plasma membrane; and microvillus. Used to study gastric ulcer. Biomarker of hypertension. Orthologous to human OXTR (oxytocin receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; oxytocin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: OT-R; OTR; OTR1; oxcytocin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Oxtrm1Mcwi  
Genetic Models: BN-Oxtrm1Mcwi
Candidate Gene For: Bp21
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,154,374 - 147,171,723 (-)NCBIGRCr8
mRatBN7.24145,598,549 - 145,614,674 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,599,561 - 145,614,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4150,990,744 - 151,006,875 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04146,771,550 - 146,787,681 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,392,838 - 145,408,958 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,399,326 - 144,417,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,701,360 - 207,717,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,314,089 - 148,326,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14148,558,929 - 148,571,638 (-)NCBI
Celera4134,168,869 - 134,184,999 (-)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicuculline  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
oxytocin  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. Arthur P, etal., J Physiol. 2008 Dec 15;586(Pt 24):6063-76. Epub 2008 Oct 20.
2. Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Asad M, etal., Life Sci. 2001 Nov 21;70(1):17-24.
3. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. Bale TL, etal., J Neurosci. 2001 Apr 1;21(7):2546-52.
4. Oxytocin receptor binding in the hypothalamus during gestation in rats. Bealer SL, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R53-8.
5. Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition. Breton JD, etal., Mol Pain. 2008 May 29;4:19.
6. Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Chen Q, etal., Neuropeptides. 2000 Jun-Aug;34(3-4):173-80.
7. Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation. Chruścicka B, etal., ACS Chem Neurosci. 2019 Jul 17;10(7):3225-3240. doi: 10.1021/acschemneuro.8b00665. Epub 2019 May 8.
8. Brain oxytocin receptors mediate ejaculation elicited by 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in anaesthetized rats. Clement P, etal., Br J Pharmacol. 2008 Jul;154(5):1150-9. Epub 2008 May 12.
9. Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus. Fang X, etal., Am J Reprod Immunol. 2000 Aug;44(2):65-72.
10. Estradiol Upregulates the Expression of Oxytocin Receptor in Colon in Rats. Feng M, etal., Am J Physiol Endocrinol Metab. 2009 Mar 3.
11. Oxytocin receptor activity in the ventrocaudal periaqueductal gray modulates anxiety-related behavior in postpartum rats. Figueira RJ, etal., Behav Neurosci. 2008 Jun;122(3):618-28.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores. Hoare S, etal., J Biol Chem. 1999 Oct 1;274(40):28682-9.
15. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
16. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Huber D, etal., Science. 2005 Apr 8;308(5719):245-8.
17. Oxytocin in cardiac ontogeny. Jankowski M, etal., Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13074-9. Epub 2004 Aug 17.
18. Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams. Jarrett TM, etal., Neuropeptides. 2006 Jun;40(3):161-7. Epub 2006 May 4.
19. Molecular cloning and functional characterization of the oxytocin receptor from a rat pancreatic cell line (RINm5F). Jeng YJ, etal., Neuropeptides 1996 Dec;30(6):557-65.
20. Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams. Johns JM, etal., Int J Dev Neurosci. 2004 Aug-Oct;22(5-6):321-8.
21. Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice. Kasahara Y, etal., Endocrinology. 2013 Nov;154(11):4305-15. doi: 10.1210/en.2012-2206. Epub 2013 Sep 3.
22. Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin. Kennett JE, etal., Endocrinology. 2008 Dec 23.
23. Effects of oxytocin on GABA signalling in the foetal brain during delivery. Khazipov R, etal., Prog Brain Res. 2008;170:243-57.
24. Intracerebral oxytocin modulates sleep-wake behaviour in male rats. Lancel M, etal., Regul Pept. 2003 Jul 15;114(2-3):145-52.
25. Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb. Larrazolo-Lopez A, etal., Neuroscience. 2008 Mar 27;152(3):585-93. Epub 2008 Jan 25.
26. Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin. Lee PR, etal., Brain Res. 2007 Jul 2;1156:152-67. Epub 2007 Apr 22.
27. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Lukas M, etal., Neuropharmacology. 2009 Jun 26.
28. Oxytocin Pretreatment Decreases Oxytocin-induced Myometrial Contractions in Pregnant Rats in a Concentration-dependent But Not Time-dependent Manner. Magalhaes J, etal., Reprod Sci. 2009 Jan 22.
29. Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain. Martins AS, etal., Hypertension. 2005 Oct;46(4):1004-9. Epub 2005 Sep 12.
30. Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat. McCafferty GP, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R299-305. Epub 2007 Mar 29.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Parathyroid hormone-related protein treatment of pregnant rats delays the increase in connexin 43 and oxytocin receptor expression in the myometrium. Mitchell JA, etal., Biol Reprod. 2003 Aug;69(2):556-62. Epub 2003 Apr 16.
33. Intrauterine oxytocin system. Compartmental distribution of oxytocin and oxytocin receptors in rat endometrial epithelium. Morel G, etal., Cell Tissue Res. 2001 Jun;304(3):377-82.
34. Oxytocin receptor gene expression in rat uterus: regulation by ovarian steroids. Murata T, etal., J Endocrinol. 2000 Jul;166(1):45-52.
35. Changes of receptor mRNAs for oxytocin and estrogen during the estrous cycle in rat uterus. Murata T, etal., J Vet Med Sci. 2003 Jun;65(6):707-12.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus. Onaka T, etal., Eur J Neurosci. 2003 Dec;18(11):3018-26.
38. Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus. Patisaul HB, etal., Brain Res. 2003 Jul 18;978(1-2):185-93.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide synthase and estrogen receptor mRNAs expression in rat heart. Pournajafi-Nazarloo H, etal., Peptides. 2007 Jun;28(6):1170-7. Epub 2007 May 6.
41. GOA pipeline RGD automated data pipeline
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Structure, characterization, and expression of the rat oxytocin receptor gene. Rozen F, etal., Proc Natl Acad Sci U S A 1995 Jan 3;92(1):200-4.
44. Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. Strakova Z and Soloff MS, Am J Physiol. 1997 May;272(5 Pt 1):E870-6.
45. ERK2 mediates oxytocin-stimulated PGE2 synthesis. Strakova Z, etal., Am J Physiol. 1998 Apr;274(4 Pt 1):E634-41.
46. Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus. Theodosis DT, etal., Mol Cell Neurosci. 2006 Apr;31(4):785-94. Epub 2006 Feb 20.
47. A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Thompson MR, etal., Neuroscience. 2007 May 11;146(2):509-14. Epub 2007 Mar 23.
48. Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake. Verty AN, etal., Neuropharmacology. 2004 Sep;47(4):593-603.
49. Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Wang D, etal., Cardiovasc Res. 2003 Jan;57(1):186-94.
50. Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. Welch MG, etal., J Comp Neurol. 2009 Jan 10;512(2):256-70.
51. Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus. Widmer H, etal., J Physiol. 2003 Apr 1;548(Pt 1):233-44. Epub 2003 Feb 14.
52. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Wu CL, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Apr;367(4):406-13. Epub 2003 Feb 26.
53. Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale. Zaninetti M and Raggenbass M, Eur J Neurosci. 2000 Nov;12(11):3975-84.
54. Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function. Zhou L, etal., Int J Neuropsychopharmacol. 2014 Oct 31;18(1):pyu009. doi: 10.1093/ijnp/pyu009.
55. The oxytocin receptor. Zingg HH and Laporte SA, Trends Endocrinol Metab. 2003 Jul;14(5):222-7.
Additional References at PubMed
PMID:12486173   PMID:12517588   PMID:12834434   PMID:14614214   PMID:16033890   PMID:17170070   PMID:17504438   PMID:17628000   PMID:18006631   PMID:18552879   PMID:19057146   PMID:19258669  
PMID:19309416   PMID:19429063   PMID:19807846   PMID:20224888   PMID:20671291   PMID:21750583   PMID:21820489   PMID:21858088   PMID:22044052   PMID:22178314   PMID:22286791   PMID:22824810  
PMID:23102456   PMID:23219972   PMID:23474276   PMID:23500836   PMID:24055336   PMID:24834854   PMID:24877632   PMID:25011012   PMID:25152590   PMID:25486578   PMID:25565097   PMID:25637830  
PMID:25740340   PMID:26122287   PMID:26590611   PMID:26630388   PMID:27132494   PMID:27235738   PMID:27389643   PMID:28575174   PMID:28739524   PMID:29118105   PMID:30071278   PMID:30898126  
PMID:32705167   PMID:32726160   PMID:33077706   PMID:33201416   PMID:33341872   PMID:33427399   PMID:34445168   PMID:34530103   PMID:34839083   PMID:35007255   PMID:35104164   PMID:35361281  
PMID:35785764   PMID:37002874   PMID:38203176  


Genomics

Comparative Map Data
Oxtr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,154,374 - 147,171,723 (-)NCBIGRCr8
mRatBN7.24145,598,549 - 145,614,674 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,599,561 - 145,614,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4150,990,744 - 151,006,875 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04146,771,550 - 146,787,681 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,392,838 - 145,408,958 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,399,326 - 144,417,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,701,360 - 207,717,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,314,089 - 148,326,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14148,558,929 - 148,571,638 (-)NCBI
Celera4134,168,869 - 134,184,999 (-)NCBICelera
Cytogenetic Map4q41NCBI
OXTR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3838,741,269 - 8,769,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl38,750,381 - 8,769,628 (-)EnsemblGRCh38hg38GRCh38
GRCh3738,792,067 - 8,811,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,767,094 - 8,786,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 3438,767,093 - 8,786,300NCBI
Celera38,726,881 - 8,746,086 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef38,726,158 - 8,745,365 (-)NCBIHuRef
CHM1_138,742,513 - 8,761,719 (-)NCBICHM1_1
T2T-CHM13v2.038,741,551 - 8,760,789 (-)NCBIT2T-CHM13v2.0
Oxtr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,450,646 - 112,467,800 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,450,644 - 112,466,904 (-)EnsemblGRCm39 Ensembl
GRCm386112,473,683 - 112,491,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,473,683 - 112,489,943 (-)EnsemblGRCm38mm10GRCm38
MGSCv376112,423,678 - 112,439,802 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366112,439,461 - 112,455,585 (-)NCBIMGSCv36mm8
Celera6114,311,708 - 114,327,999 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.27NCBI
Oxtr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561337,902 - 354,336 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955561340,387 - 354,499 (-)NCBIChiLan1.0ChiLan1.0
OXTR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v228,760,557 - 8,779,263 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan138,765,328 - 8,784,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v038,701,344 - 8,721,706 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.138,962,454 - 8,963,730 (-)NCBIpanpan1.1PanPan1.1panPan2
OXTR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1209,358,797 - 9,382,308 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl209,358,916 - 9,378,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha209,392,409 - 9,411,729 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0209,388,927 - 9,412,408 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl209,388,090 - 9,410,068 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1209,110,306 - 9,130,001 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0209,455,823 - 9,475,105 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0209,429,314 - 9,449,013 (+)NCBIUU_Cfam_GSD_1.0
Oxtr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,650,853 - 14,668,467 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366024,241,737 - 4,260,549 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366024,241,743 - 4,259,866 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXTR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,134,057 - 65,153,487 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,134,055 - 65,155,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21372,415,345 - 72,436,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OXTR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,746,108 - 44,764,501 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2244,742,419 - 44,763,243 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041121,803,523 - 121,822,069 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oxtr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247313,370,701 - 3,385,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247313,367,645 - 3,384,815 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Oxtr
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000007724
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat

Markers in Region
AU047790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,614,933 - 145,615,073 (+)MAPPERmRatBN7.2
Rnor_6.04144,416,461 - 144,416,600NCBIRnor6.0
Rnor_5.04207,716,718 - 207,716,857UniSTSRnor5.0
RGSC_v3.44148,327,172 - 148,327,311UniSTSRGSC3.4
Celera4134,185,259 - 134,185,398UniSTS
Cytogenetic Map4q42UniSTS
PMC170950P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,613,871 - 145,614,261 (+)MAPPERmRatBN7.2
Rnor_6.04144,415,399 - 144,415,788NCBIRnor6.0
Rnor_5.04207,715,656 - 207,716,045UniSTSRnor5.0
RGSC_v3.44148,326,110 - 148,326,499UniSTSRGSC3.4
Celera4134,184,197 - 134,184,586UniSTS
Cytogenetic Map4q42UniSTS
Oxtr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,613,875 - 145,614,537 (+)MAPPERmRatBN7.2
Rnor_6.04144,415,403 - 144,416,064NCBIRnor6.0
Rnor_5.04207,715,660 - 207,716,321UniSTSRnor5.0
RGSC_v3.44148,326,114 - 148,326,775UniSTSRGSC3.4
Celera4134,184,201 - 134,184,862UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Oxtr is modified in the following models/strains:
BN-Oxtrm1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 14 8 6 6 35 21 12 3 6
Below cutoff 1 12 4 3 7 3 2 2 29 14 19 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF257237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY338194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY798256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L81169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007724   ⟹   ENSRNOP00000007724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4145,599,561 - 145,614,674 (-)Ensembl
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)Ensembl
RefSeq Acc Id: NM_012871   ⟹   NP_037003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,154,374 - 147,170,499 (-)NCBI
mRatBN7.24145,598,549 - 145,614,674 (-)NCBI
Rnor_6.04144,399,326 - 144,416,201 (-)NCBI
Rnor_5.04207,701,360 - 207,717,840 (-)NCBI
RGSC_v3.44148,314,089 - 148,326,797 (-)RGD
Celera4134,168,869 - 134,184,999 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285601   ⟹   XP_063141671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,154,374 - 147,171,691 (-)NCBI
RefSeq Acc Id: XM_063285602   ⟹   XP_063141672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,154,374 - 147,171,691 (-)NCBI
RefSeq Acc Id: XM_063285603   ⟹   XP_063141673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,154,374 - 147,171,723 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037003   ⟸   NM_012871
- UniProtKB: Q53ZC5 (UniProtKB/Swiss-Prot),   P70536 (UniProtKB/Swiss-Prot),   A6IBN2 (UniProtKB/TrEMBL),   Q8R561 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007724   ⟸   ENSRNOT00000007724
RefSeq Acc Id: XP_063141673   ⟸   XM_063285603
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063141672   ⟸   XM_063285602
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063141671   ⟸   XM_063285601
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70536-F1-model_v2 AlphaFold P70536 1-388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3239 AgrOrtholog
BioCyc Gene G2FUF-43419 BioCyc
Ensembl Genes ENSRNOG00000005806 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006840 UniProtKB/Swiss-Prot
  ENSRNOG00060012922 UniProtKB/Swiss-Prot
  ENSRNOG00065027143 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007724 ENTREZGENE
  ENSRNOT00000007724.3 UniProtKB/Swiss-Prot
  ENSRNOT00055011240 UniProtKB/Swiss-Prot
  ENSRNOT00060021981 UniProtKB/Swiss-Prot
  ENSRNOT00065046779 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxytocn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25342 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25342 ENTREZGENE
PANTHER NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OXYTOCIN RECEPTOR UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oxtr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OXYTOCINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005806 RatGTEx
  ENSRNOG00055006840 RatGTEx
  ENSRNOG00060012922 RatGTEx
  ENSRNOG00065027143 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IBN2 ENTREZGENE, UniProtKB/TrEMBL
  OXYR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q53ZC5 ENTREZGENE
  Q8R561 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q53ZC5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Oxtr  oxytocin receptor    oxcytocin receptor  Name updated 1299863 APPROVED
2002-06-10 Oxtr  oxcytocin receptor      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein expressed in heart chambers 631223
gene_other mapped to the vicinity of the Bp21 QTL region and proposed to be a candidate gene for blood pressure regulation 631223
gene_process may be involved in cardiovascular functions and hypertension 631223
gene_process stimulates prostaglandin release in uterine endometrium 729203
gene_transcript gene contains multiple interleukin-response elements and four STAT3 binding motifs 69917