OXTR (oxytocin receptor) - Rat Genome Database

Name: OXTR
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: OXTR (oxytocin receptor) Pan paniscus

Analyze

Symbol:

OXTR

Name:

oxytocin receptor

RGD ID:

11976427

Description:

ENCODES a protein that exhibits ionotropic glutamate receptor binding (ortholog); oxytocin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN digestive tract development (ortholog); eating behavior (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; oxytocin signaling pathway; ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); microvillus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC100977222; uncharacterized LOC100977222

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OXTR (oxytocin receptor)	NCBI	Ortholog
Mus musculus (house mouse):	Oxtr (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Oxtr (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Oxtr (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OXTR (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Oxtr (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OXTR (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OXTR (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Oxtr (oxytocin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	8,760,557 - 8,779,263 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	8,765,328 - 8,784,021 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	8,701,344 - 8,721,706 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	8,962,454 - 8,963,730 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Atrioventricular Septal Defect 2 (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

cardiomyopathy (ISO)

Chromosome 3, Monosomy 3p25 (ISO)

cognitive disorder (ISO)

distal myopathy Tateyama type (ISO)

familial hypertrophic cardiomyopathy (ISO)

gastric ulcer (ISO)

genetic disease (ISO)

hypertension (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 1 (ISO)

Hypoxia (ISO)

isolated elevated serum creatine phosphokinase levels (ISO)

Joubert syndrome 9 (ISO)

limb-girdle muscular dystrophy (ISO)

long QT syndrome (ISO)

long QT syndrome 1 (ISO)

long QT syndrome 9 (ISO)

lung non-small cell carcinoma (ISO)

Neurodevelopmental Disorders (ISO)

rippling muscle disease 2 (ISO)

Romano-Ward Syndrome (ISO)

schizophrenia (ISO)

sudden infant death syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

digestive tract development (ISO)

eating behavior (ISO)

ERK1 and ERK2 cascade (ISO)

estrous cycle (ISO)

female pregnancy (ISO)

G protein-coupled receptor signaling pathway (ISO)

heart development (ISO)

maternal behavior (ISO)

maternal process involved in parturition (ISO)

memory (ISO)

positive regulation of blood pressure (ISO)

positive regulation of cold-induced thermogenesis (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of norepinephrine secretion (ISO)

positive regulation of penile erection (ISO)

positive regulation of synapse assembly (ISO)

positive regulation of synaptic transmission, GABAergic (ISO)

positive regulation of synaptic transmission, glutamatergic (ISO)

positive regulation of uterine smooth muscle contraction (ISO)

response to amphetamine (ISO)

response to anoxia (ISO)

response to cocaine (ISO)

response to cytokine (ISO)

response to estradiol (ISO)

response to organic cyclic compound (ISO)

response to peptide hormone (ISO)

response to progesterone (ISO)

response to steroid hormone (ISO)

response to xenobiotic stimulus (ISO)

social behavior (ISO)

sperm ejaculation (ISO)

suckling behavior (ISO)

telencephalon development (ISO)

Cellular Component

adherens junction (ISO)

apical plasma membrane (ISO)

microvillus (ISO)

Molecular Function

ionotropic glutamate receptor binding (ISO)

oxytocin receptor activity (ISO)

peptide hormone binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

G protein mediated signaling pathway via Galphai family (ISO)

G protein mediated signaling pathway via Galphaq family (ISO)

oxytocin signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

OXTR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	8,760,557 - 8,779,263 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	8,765,328 - 8,784,021 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	8,701,344 - 8,721,706 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	8,962,454 - 8,963,730 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

OXTR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	8,741,269 - 8,769,613 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	8,750,381 - 8,769,628 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	8,792,067 - 8,811,299 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	8,767,094 - 8,786,300 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	8,767,093 - 8,786,300	NCBI
Celera	3	8,726,881 - 8,746,086 (-)	NCBI		Celera
Cytogenetic Map	3	p25.3	NCBI
HuRef	3	8,726,158 - 8,745,365 (-)	NCBI		HuRef
CHM1_1	3	8,742,513 - 8,761,719 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	8,741,551 - 8,760,789 (-)	NCBI		T2T-CHM13v2.0

Oxtr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	112,450,646 - 112,467,800 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	112,450,644 - 112,466,904 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	112,473,683 - 112,491,035 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	112,473,683 - 112,489,943 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	112,423,678 - 112,439,802 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	112,439,461 - 112,455,585 (-)	NCBI		MGSCv36	mm8
Celera	6	114,311,708 - 114,327,999 (-)	NCBI		Celera
Cytogenetic Map	6	E3	NCBI
cM Map	6	52.27	NCBI

Oxtr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	147,154,374 - 147,171,723 (-)	NCBI		GRCr8
mRatBN7.2	4	145,598,549 - 145,614,674 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	145,599,561 - 145,614,674 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	150,990,744 - 151,006,875 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	146,771,550 - 146,787,681 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	145,392,838 - 145,408,958 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	144,399,326 - 144,417,598 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	144,403,358 - 144,416,116 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	207,701,360 - 207,717,840 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	148,314,089 - 148,326,797 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	148,558,929 - 148,571,638 (-)	NCBI
Celera	4	134,168,869 - 134,184,999 (-)	NCBI		Celera
Cytogenetic Map	4	q41	NCBI

Oxtr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955561	337,902 - 354,336 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955561	340,387 - 354,499 (-)	NCBI	ChiLan1.0	ChiLan1.0

OXTR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	9,358,797 - 9,382,308 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	9,358,916 - 9,378,343 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	9,392,409 - 9,411,729 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	9,388,927 - 9,412,408 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	9,388,090 - 9,410,068 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	9,110,306 - 9,130,001 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	9,455,823 - 9,475,105 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	9,429,314 - 9,449,013 (+)	NCBI		UU_Cfam_GSD_1.0

Oxtr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	14,650,853 - 14,668,467 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936602	4,241,737 - 4,260,549 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936602	4,241,743 - 4,259,866 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OXTR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	65,134,057 - 65,153,487 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	65,134,055 - 65,155,543 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	72,415,345 - 72,436,029 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OXTR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	44,746,108 - 44,764,501 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	44,742,419 - 44,763,243 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	121,803,523 - 121,822,069 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Oxtr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	3,370,701 - 3,385,640 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	3,367,645 - 3,384,815 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034955695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055110898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_055110898 ⟹ XP_054966873

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	8,760,557 - 8,779,263 (-)	NCBI
NHGRI_mPanPan1	3	8,765,328 - 8,784,021 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_054966873	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_054966873 ⟸ XM_055110898

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	OXTR	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-07-01	OXTR	oxytocin receptor	LOC100977222	uncharacterized LOC100977222	Symbol and/or name change	5135510	APPROVED
2020-06-11	LOC100977222	uncharacterized LOC100977222	OXTR	oxytocin receptor	Data merged from RGD:13550890	737654	PROVISIONAL
2018-05-08	LOC100977222	uncharacterized LOC100977222	OXTR	oxytocin receptor	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations