RGD Reference Report - Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus. - Rat Genome Database

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Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus.

Authors: Theodosis, DT  Koksma, JJ  Trailin, A  Langle, SL  Piet, R  Lodder, JC  Timmerman, J  Mansvelder, H  Poulain, DA  Oliet, SH  Brussaard, AB 
Citation: Theodosis DT, etal., Mol Cell Neurosci. 2006 Apr;31(4):785-94. Epub 2006 Feb 20.
RGD ID: 2304173
Pubmed: PMID:16488155   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mcn.2006.01.006   (Journal Full-text)

We here investigated inhibitory synapse turnover in the adult brain using the hypothalamic supraoptic nucleus where new synapses form during different physiological conditions, in particular on oxytocin neurons largely controlled by GABAergic inputs and locally released oxytocin. Patch clamp recordings and ultrastructural analysis of the nucleus in acute slices from late gestating rats showed that oxytocin and estrogen promoted rapid formation of inhibitory synapses. Thus, after 2-h exposure to a combination of oxytocin and 17-beta estradiol, the frequency of miniature inhibitory postsynaptic currents was significantly enhanced. Since their amplitude and presynaptic GABA release probability were unmodified, this indicated an increased number of synapses. Electron microscopy confirmed increased densities of symmetric, putative GABAergic synapses within 2-h exposure to the peptide or steroid, effects which were reversible and oxytocin receptor mediated. Our observations thus offer direct evidence that hypothalamic GABAergic microcircuitries can undergo rapid and functional remodeling under changing neuroendocrine conditions.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of synapse assembly  IDA 2304173 RGD 
positive regulation of synapse assembly  IMP 2304173 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Oxt  (oxytocin/neurophysin I prepropeptide)
Oxtr  (oxytocin receptor)


Additional Information