RGD Reference Report - Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. - Rat Genome Database

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Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs.

Authors: Asad, M  Shewade, DG  Koumaravelou, K  Abraham, BK  Vasu, S  Ramaswamy, S 
Citation: Asad M, etal., Life Sci. 2001 Nov 21;70(1):17-24.
RGD ID: 2304192
Pubmed: PMID:11764003   (View Abstract at PubMed)

The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied. The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by cysteamine hydrochloride. Oxytocin showed significant antisecretory and antiulcer activity in pylorus ligated rats. Similarly oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats. The antiulcer and antisecretory effect was comparable to that of ranitidine (50mg/kg, i.p) though less in intensity. However, it did not show any gastric cytoprotective effect in ethanol and indomethacin induced ulcer models but ranitidine showed protection (p<0.05) in later model. Oxytocin enhanced gastric ulcer healing in acetic acid induced chronic gastric ulcer model. The reversal of oxytocin effect by atosiban, an oxytocin receptor antagonist indicates a role for oxytocin receptors. The antiulcer activity of oxytocin can be attributed to its antisecretory effect.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
gastric ulcer  ISOOxt (Rattus norvegicus)2304192; 2304192 RGD 
gastric ulcer  ISOOxtr (Rattus norvegicus)2304192; 2304192 RGD 
gastric ulcer  IDA 2304192 RGD 
gastric ulcer  IMP 2304192 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Oxt  (oxytocin/neurophysin I prepropeptide)
Oxtr  (oxytocin receptor)

Genes (Mus musculus)
Oxt  (oxytocin)
Oxtr  (oxytocin receptor)

Genes (Homo sapiens)
OXT  (oxytocin/neurophysin I prepropeptide)
OXTR  (oxytocin receptor)


Additional Information