Nr3c2 (nuclear receptor subfamily 3, group C, member 2) - Rat Genome Database

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Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Rattus norvegicus
Analyze
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
RGD ID: 3094
Description: Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and transcription coactivator binding activity. Involved in several processes, including nuclear receptor-mediated corticosteroid signaling pathway; positive regulation of transcription by RNA polymerase II; and response to mineralocorticoid. Located in cytoplasm and nucleus. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Used to study alcohol use disorder; morphine dependence; and polycystic ovary syndrome. Biomarker of alcohol dependence; fetal alcohol spectrum disorder; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1; opioid abuse; and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2); PARTICIPATES IN aldosterone signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MCR; mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); Mlr; MR; nuclear receptor subfamily 3 group C member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Salc2   Gmadr1   Bw28  
Candidate Gene For: Salc2 Gmadr1 Bw28 Bw130
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,619,853 - 47,964,089 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1947,619,853 - 47,964,078 (-)EnsemblGRCr8
mRatBN7.21930,715,634 - 31,059,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1937,554,315 - 37,898,523 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01938,208,168 - 38,552,393 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01940,460,411 - 40,809,228 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)Ensemblrn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1930,192,512 - 30,534,995 (-)NCBICelera
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (EXP)
11-deoxycortisol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acephate  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (ISO)
aldosterone  (EXP,ISO)
allethrin  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
beclomethasone  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
betamethasone  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bleomycin A2  (EXP)
budesonide  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
candesartan  (EXP)
canrenoic acid  (EXP)
carbamazepine  (ISO)
carnosic acid  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corticosterone  (EXP,ISO)
cortisol  (ISO)
cortisone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dimethoate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drospirenone  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP)
enzacamene  (EXP)
eplerenone  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP,ISO)
fipronil  (ISO)
flavonoids  (EXP)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
gypenoside LXXV  (ISO)
hydrochlorothiazide  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
lycopene  (ISO)
medroxyprogesterone acetate  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
mometasone furoate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
permethrin  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
pyrethrins  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
spironolactone  (EXP,ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
terbutylazine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torasemide  (EXP)
torcetrapib  (ISO)
trametinib  (ISO)
triamcinolone  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP,ISO)
zineb  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid-a familiar foe. Adeyanju OA, etal., Naunyn Schmiedebergs Arch Pharmacol. 2020 Jun;393(6):1055-1066. doi: 10.1007/s00210-020-01809-1. Epub 2020 Jan 10.
2. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Aoun EG, etal., Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.
3. Blocking the Mineralocorticoid Receptor Improves Cognitive Impairment after Anesthesia/Splenectomy in Rats. Feng X, etal., Int J Med Sci. 2021 Jan 1;18(2):387-397. doi: 10.7150/ijms.48767. eCollection 2021.
4. Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats. Francis J, etal., Am J Physiol Regul Integr Comp Physiol 2003 Feb;284(2):R328-35.
5. Characterization of transactivational property and coactivator mediation of rat mineralocorticoid receptor activation function-1 (AF-1). Fuse H, etal., Mol Endocrinol. 2000 Jun;14(6):889-99. doi: 10.1210/mend.14.6.0467.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Ge RS, etal., Mol Cell Endocrinol. 2005 Nov 24;243(1-2):35-42. Epub 2005 Sep 26.
8. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Geller DS, etal., Nat Genet. 1998 Jul;19(3):279-81.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Ishizawa K, etal., Hypertension. 2005 Oct;46(4):1046-52. doi: 10.1161/01.HYP.0000172622.51973.f5. Epub 2005 Aug 8.
11. Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain. Kalman BA and Spencer RL, Endocrinology 2002 Nov;143(11):4184-95.
12. Marinobufagenin in Urine: A Potential Marker of Predisposition to Ethanol and a Target for Spironolactone. Kashkin VA, etal., Curr Hypertens Rev. 2018;14(1):35-38. doi: 10.2174/1573402114666180212115518.
13. Chronic intermittent stress does not differentially alter brain corticosteroid receptor densities in rats prenatally exposed to ethanol. Kim CK, etal., Psychoneuroendocrinology. 1999 Aug;24(6):585-611. doi: 10.1016/s0306-4530(99)00015-3.
14. Ligand-selective potentiation of rat mineralocorticoid receptor activation function 1 by a CBP-containing histone acetyltransferase complex. Kitagawa H, etal., Mol Cell Biol 2002 Jun;22(11):3698-706.
15. Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: Sex- and time-dependent effects. Lam VYY, etal., Psychoneuroendocrinology. 2018 Nov;97:8-19. doi: 10.1016/j.psyneuen.2018.06.018. Epub 2018 Jun 23.
16. Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain. Lan N, etal., Neuroscience. 2017 Feb 7;342:167-179. doi: 10.1016/j.neuroscience.2015.08.058. Epub 2015 Sep 2.
17. Drug addiction and stress-response genetic variability: association study in African Americans. Levran O, etal., Ann Hum Genet. 2014 Jul;78(4):290-8. doi: 10.1111/ahg.12064. Epub 2014 Apr 26.
18. Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action. Li G, etal., J Biol Chem. 2003 Oct 24;278(43):41779-88. Epub 2003 Aug 5.
19. Steroid receptor heterodimerization demonstrated in vitro and in vivo. Liu W, etal., Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12480-4.
20. Central amygdala mineralocorticoid receptors modulate alcohol self-administration. Makhijani VH, etal., Neuropharmacology. 2020 Dec 15;181:108337. doi: 10.1016/j.neuropharm.2020.108337. Epub 2020 Sep 29.
21. The mineralocorticoid receptor antagonist spironolactone reduces alcohol self-administration in female and male rats. Makhijani VH, etal., Pharmacol Biochem Behav. 2018 Dec;175:10-18. doi: 10.1016/j.pbb.2018.07.011. Epub 2018 Aug 29.
22. Gain of function mutation in the mineralocorticoid receptor of the Brown Norway rat. Marissal-Arvy N, etal., J Biol Chem 2004 Sep 17;279(38):39232-9. Epub 2004 Jul 12.
23. Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats. Mesripour A, etal., Basic Clin Pharmacol Toxicol. 2012 Aug;111(2):75-80. doi: 10.1111/j.1742-7843.2012.00860.x. Epub 2012 Feb 28.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
26. Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR). Navarro-Zaragoza J, etal., Toxicology. 2014 Dec 4;326:36-43. doi: 10.1016/j.tox.2014.10.002. Epub 2014 Oct 11.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Molecular cloning of a mineralocorticoid (type I) receptor complementary DNA from rat hippocampus. Patel PD, etal., Mol Endocrinol 1989 Nov;3(11):1877-85.
31. Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor. Pilipuk GP, etal., Biochemistry. 2007 Feb 6;46(5):1389-97.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
34. Localization of mineralocorticoid receptors at mammalian synapses. Prager EM, etal., PLoS One. 2010 Dec 15;5(12):e14344.
35. Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism. Pujo L, etal., Hum Mutat. 2007 Jan;28(1):33-40.
36. Impact of adolescent stress on the expression of stress-related receptors in the hippocampus of animals exposed to alcohol prenatally. Raineki C, etal., Hippocampus. 2018 Mar;28(3):201-216. doi: 10.1002/hipo.22823. Epub 2018 Jan 8.
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Atrial natriuretic peptide inhibits mineralocorticoid receptor function in rat colonic surface cells. Schulman G, etal., J Clin Invest. 1996 Jul 1;98(1):157-66.
40. Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. Uban KA, etal., Psychoneuroendocrinology. 2013 Oct;38(10):1953-66. doi: 10.1016/j.psyneuen.2013.02.017. Epub 2013 Apr 8.
41. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Van Waes V, etal., Eur J Neurosci. 2006 Aug;24(4):1193-200. doi: 10.1111/j.1460-9568.2006.04973.x. Epub 2006 Aug 21.
42. Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus. Wong EY and Herbert J, Eur J Neurosci. 2005 Aug;22(4):785-92.
43. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:7495694   PMID:7982810   PMID:8401570   PMID:9111344   PMID:9677313   PMID:9689096   PMID:10687858   PMID:11809749   PMID:12810555   PMID:12943733   PMID:14960289   PMID:15100355  
PMID:15280098   PMID:15289366   PMID:15699469   PMID:15940303   PMID:15975997   PMID:16580234   PMID:16627578   PMID:17244200   PMID:17347454   PMID:17546625   PMID:17670862   PMID:17715265  
PMID:18337591   PMID:18434352   PMID:18547242   PMID:19007760   PMID:19038868   PMID:19261739   PMID:19433261   PMID:19541744   PMID:19638349   PMID:19819939   PMID:19875699   PMID:19966502  
PMID:20196138   PMID:20421514   PMID:20466668   PMID:20861076   PMID:21135038   PMID:21248754   PMID:22205374   PMID:22371232   PMID:22564091   PMID:22579827   PMID:22871113   PMID:22911865  
PMID:23096235   PMID:23152847   PMID:23290935   PMID:23382219   PMID:23470864   PMID:24040049   PMID:24913911   PMID:25109280   PMID:25555524   PMID:26073023   PMID:26305887   PMID:26336165  
PMID:26403275   PMID:26598419   PMID:27215035   PMID:28324065   PMID:28472300   PMID:28523794   PMID:30769772   PMID:32305433   PMID:32582979   PMID:38255827  


Genomics

Comparative Map Data
Nr3c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,619,853 - 47,964,089 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1947,619,853 - 47,964,078 (-)EnsemblGRCr8
mRatBN7.21930,715,634 - 31,059,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1937,554,315 - 37,898,523 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01938,208,168 - 38,552,393 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01940,460,411 - 40,809,228 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)Ensemblrn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1930,192,512 - 30,534,995 (-)NCBICelera
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Cytogenetic Map19q11NCBI
NR3C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384148,078,764 - 148,445,322 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4148,078,762 - 148,445,549 (-)Ensemblhg38GRCh38
GRCh374148,999,915 - 149,365,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364149,219,370 - 149,582,973 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344149,357,524 - 149,721,128NCBI
Celera4146,321,236 - 146,684,999 (-)NCBICelera
Cytogenetic Map4q31.23NCBI
HuRef4144,727,062 - 145,090,717 (-)NCBIHuRef
CHM1_14148,978,561 - 149,342,342 (-)NCBICHM1_1
T2T-CHM13v2.04151,402,689 - 151,769,419 (-)NCBIT2T-CHM13v2.0
Nr3c2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39877,626,422 - 77,971,641 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl877,626,070 - 77,971,641 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38876,898,083 - 77,245,012 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl876,899,442 - 77,245,012 (+)Ensemblmm10GRCm38
MGSCv37879,426,407 - 79,767,538 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36879,765,155 - 80,141,081 (+)NCBIMGSCv36mm8
Celera881,194,433 - 81,532,459 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.34NCBI
Nr3c2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554713,061,735 - 3,395,520 (-)Ensembl
ChiLan1.0NW_0049554713,059,210 - 3,397,894 (-)NCBIChiLan1.0ChiLan1.0
NR3C2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23145,955,891 - 146,322,035 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14146,318,234 - 146,684,514 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04140,418,624 - 140,785,180 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14152,072,962 - 152,435,965 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4152,108,508 - 152,430,298 (-)EnsemblpanPan2panpan1.1
NR3C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11546,390,030 - 46,718,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1546,390,023 - 46,710,131 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1546,783,147 - 47,111,076 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01547,065,842 - 47,394,398 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1547,065,445 - 47,392,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11546,332,314 - 46,660,048 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01546,430,796 - 46,758,507 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,738,917 - 47,073,793 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr3c2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530143,702,929 - 44,030,134 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,140,178 - 1,467,471 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365351,139,687 - 1,467,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR3C2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl880,312,234 - 80,668,412 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1880,303,172 - 80,669,050 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2885,308,914 - 85,644,752 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR3C2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1794,574,010 - 94,935,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603774,281,853 - 74,644,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr3c2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11724,130,093 - 24,468,185 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr3c2
1334 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000052018
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)194172060949971820Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat

Markers in Region
PMC124545P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21931,050,713 - 31,051,033 (+)MAPPERmRatBN7.2
Rnor_6.01934,751,833 - 34,752,152NCBIRnor6.0
Rnor_5.01945,630,664 - 45,630,983UniSTSRnor5.0
RGSC_v3.41932,866,199 - 32,866,518UniSTSRGSC3.4
Celera1930,525,825 - 30,526,144UniSTS
Cytogenetic Map19q11UniSTS
NR3C2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21931,050,406 - 31,050,654 (+)MAPPERmRatBN7.2
Rnor_6.01934,751,526 - 34,751,773NCBIRnor6.0
Rnor_5.01945,630,357 - 45,630,604UniSTSRnor5.0
RGSC_v3.41932,865,892 - 32,866,139UniSTSRGSC3.4
Celera1930,525,518 - 30,525,765UniSTS
Cytogenetic Map19q11UniSTS
RH130444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,715,814 - 30,716,011 (+)MAPPERmRatBN7.2
Rnor_6.01934,408,442 - 34,408,638NCBIRnor6.0
Rnor_5.01945,287,609 - 45,287,805UniSTSRnor5.0
RGSC_v3.41932,527,919 - 32,528,115UniSTSRGSC3.4
Celera1930,192,679 - 30,192,875UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 12 85 206 91 90 59 110 59 6 444 237 20 179 117 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000052018   ⟹   ENSRNOP00000045942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1947,619,853 - 47,964,078 (-)Ensembl
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)Ensembl
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096148   ⟹   ENSRNOP00000081905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1947,619,853 - 47,964,078 (-)Ensembl
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144737   ⟹   ENSRNOP00000109891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1947,619,853 - 47,961,586 (-)Ensembl
RefSeq Acc Id: NM_001395077   ⟹   NP_001382006
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,853 - 47,962,284 (-)NCBI
mRatBN7.21930,715,634 - 31,058,091 (-)NCBI
RefSeq Acc Id: NM_013131   ⟹   NP_037263
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,853 - 47,964,078 (-)NCBI
mRatBN7.21930,715,634 - 31,059,885 (-)NCBI
Rnor_6.01934,408,275 - 34,761,003 (-)NCBI
Rnor_5.01945,287,442 - 45,639,834 (-)NCBI
RGSC_v3.41932,527,752 - 32,875,369 (-)RGD
Celera1930,192,512 - 30,534,995 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097523   ⟹   XP_038953451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,962,073 (-)NCBI
mRatBN7.21930,718,100 - 31,057,367 (-)NCBI
RefSeq Acc Id: XM_039097524   ⟹   XP_038953452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,963,488 (-)NCBI
mRatBN7.21930,718,100 - 31,058,171 (-)NCBI
RefSeq Acc Id: XM_039097525   ⟹   XP_038953453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,964,089 (-)NCBI
mRatBN7.21930,718,100 - 31,059,537 (-)NCBI
RefSeq Acc Id: XM_039097526   ⟹   XP_038953454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,962,072 (-)NCBI
mRatBN7.21930,718,100 - 31,057,365 (-)NCBI
RefSeq Acc Id: NP_037263   ⟸   NM_013131
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045942   ⟸   ENSRNOT00000052018
RefSeq Acc Id: XP_038953453   ⟸   XM_039097525
- Peptide Label: isoform X1
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot),   F1M6V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953452   ⟸   XM_039097524
- Peptide Label: isoform X1
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot),   F1M6V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953451   ⟸   XM_039097523
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953454   ⟸   XM_039097526
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000081905   ⟸   ENSRNOT00000096148
RefSeq Acc Id: NP_001382006   ⟸   NM_001395077
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000109891   ⟸   ENSRNOT00000144737
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22199-F1-model_v2 AlphaFold P22199 1-981 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3094 AgrOrtholog
BioCyc Gene G2FUF-5900 BioCyc
Ensembl Genes ENSRNOG00000034007 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000052018 ENTREZGENE
  ENSRNOT00000096148 ENTREZGENE
  ENSRNOT00000144737 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR3 UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:25672 UniProtKB/Swiss-Prot
NCBI Gene 25672 ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB NR3C2 RGD
PhenoGen Nr3c2 PhenoGen
PRINTS STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000034007 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A0A8I6G6P1_RAT UniProtKB/TrEMBL
  A0ABK0LZD5_RAT UniProtKB/TrEMBL
  A6IYL2_RAT UniProtKB/TrEMBL
  F1M6V2 ENTREZGENE, UniProtKB/TrEMBL
  MCR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63763 ENTREZGENE
  Q64174 ENTREZGENE
UniProt Secondary Q63763 UniProtKB/Swiss-Prot
  Q64174 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Nr3c2  nuclear receptor subfamily 3, group C, member 2  Mlr  Mineralocorticoid receptor (aldosterone receptor)  Symbol and Name updated 625702 APPROVED
2002-06-10 Mlr  Mineralocorticoid receptor (aldosterone receptor)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression Y73C substitution in the BN/OrlIco strain is associated with increased receptor transactivation by aldosterone and also by progesterone 1302889
gene_process activation in the central nervous system plays a critical role in regulating TNF-alpha release in heart failure 729123