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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3094
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Acc ID: CHEBI:31547
Term: eplerenone
Definition: A steroid acid ester that has formula C24H30O6.
Chemical ID: MESH:C414690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c2decreases expressionEXP 401965467RGDeplerenone decreases expression of protein in hippocampus of post-surgical rats 
Nr3c2multiple interactionsEXP 6480464CTDeplerenone binds to and results in decreased activity of NR3C2 proteinPMID:15974890
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