Smad2 Rat Gene (SMAD family member 2)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene:
Smad2 ( Rattus norvegicus )
SMAD family member 2
Description: transcriptional mediator for both activin and TGFbeta
Synonyms: Madh2; MAD (mothers against decapentaplegic, Drosophila) homolog 2; MGC156656; MAD homolog 2 (Drosophila);  (details...)
ArrayIDs: A_44_P210520; 6271879; AB017912_g_at; 1368214_at; GE20574; rc_AI228675_at; AB017912_at; 5634140; 5877677; 6689851; 6502694; 6583756; 5830125; 6440808; 5956840; 6240193; 5972038; 5961567; 6621764; 5850315; 6741308; A_43_P11968; 6186385; 6138478; A_44_P308046; 5666069; 5742059; rc_AI105449_at;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: SMAD2     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Smad2     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Smad2 genome assembly 3.1 18 73253792 - 73314980
Rat Celera Assembly 18 68382092 - 68443196
RGSC genome assembly v3.4 18 73180520 - 73241713
Cytogenetic 18 q12.3
Mus musculus Smad2 Mouse genome assembly build 36.1 18 76401579 - 76465385
Cytogenetic 18 18 E3
Homo sapiens SMAD2 human genome assembly 18 43618434 - 43710924
Human genome assembly build 36.2 18 43618435 - 43711221
Cytogenetic 18 q21.1

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

co-SMAD binding,  ubiquitin protein ligase binding,  transcription factor activity ... (details...)
Biological Process

Note Reference

involved in folliculogenesis 727374

activation induces apoptosis in pancreatic AR42J cells induced by activin A 69876

an essential downstream intracellular target of the TGF-beta receptor signaling pathway 625421

Gene Ontology

heart development,  pericardium development,  paraxial mesoderm morphogenesis ... (details...)
Cellular Component

Gene Ontology

transcription factor complex,  protein complex,  nucleus ... (details...)
Disease

Note Reference

may be involved in pulmonary fibrosis 625421

Ontology

Ovarian Neoplasms,  Colorectal Neoplasms,  Carcinoma, Renal Cell ... (details...)
Pathway

Ontology

transforming growth factor-beta Smad dependent signaling pathway,  altered transforming growth factor-beta Smad dependent signaling pathway,  SMAD dependent signaling pathways ... (details...)
Product

Note Reference

member of the family of Smad proteins 625421

Regulation

Note Reference

phosphorylated by activated TGF-beta type 1 receptor 625421

Drugs

Note Reference

bleomycin at a dose of 9U/kg body weight causes no significant change in the expression of the protein 625421

External Links
Databases
DATABASE ID SOURCE
SMART: DWB IPI
SMART: DWA IPI
PROSITE: MH2 IPI
PROSITE: MH1 IPI
UNIPARC: UPI00005022F9 IPI
UNIPARC: UPI0000135A78 IPI
KEGG Report: rno:29357 ENTREZGENE
HomoloGene Group ID: 21197 ENTREZGENE
Germonline: 3031
Pfam: MH1 IPI
Pfam: MH2 IPI
KEGG Pathway: 04520 ENTREZGENE
KEGG Pathway: 05212 ENTREZGENE
KEGG Pathway: 05210 ENTREZGENE
KEGG Pathway: 04110 ENTREZGENE
KEGG Pathway: 04350 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
InterPro: SMAD_dom_Dwarfin-type. IPI
InterPro: MAD_homology1_Dwarfin-type. IPI
InterPro: SMAD_FHA_domain. IPI
InterPro: Dwarfin. IPI
InterPro: MAD_homology_MH1. IPI
InterPro: SMAD_dom-like. IPI
Ensembl Protein: ENSRNOP00000036431 IPI
Ensembl Protein: ENSRNOP00000048329 IPI
IPI: IPI00391840 IPI
IPI: IPI00198544 IPI
Gene3D-CATH: MAD_MH1 IPI
Gene3D-CATH: MH2_Dwarfin-type IPI
Entrez Gene: Smad2 ENTREZGENE
IMAGE_CLONE: IMAGE:8364718 IMAGE-MGC_LOAD
MGC_CLONE: MGC:156656 IMAGE-MGC_LOAD
TIGR: TC217521
UniProt: SMAD2_RAT IPI
Ensembl Genes: ENSRNOG00000018140 IPI
Superfamily-SCOP: MAD_MH1 IPI
Superfamily-SCOP: SMAD_FHA IPI
PANTHER: Dwarfin IPI
Sequences
Nucleotide: BC127497 Get FASTA Search GEO Profiles
Nucleotide: AB017912 Get FASTA Search GEO Profiles
Nucleotide: AB010147 Get FASTA Search GEO Profiles
Nucleotide: CH474069 Get FASTA Search GEO Profiles
Nucleotide: NM_019191 Get FASTA Search GEO Profiles
Nucleotide: AF056001 Get FASTA Search GEO Profiles
(View all 6 Nucleotide Accessions)
Protein: NP_062064 Get FASTA
Protein: EDL84734 Get FASTA
Protein: O70436 Get FASTA
Protein: BAA81909 Get FASTA
Protein: EDL84731 Get FASTA
Protein: EDL84732 Get FASTA
Protein: EDL84733 Get FASTA
Protein: AAC12780 Get FASTA
Protein: BAA33453 Get FASTA
Protein: AAI27498 Get FASTA
(View all 10 Protein Accessions)
Clusters
UniGene: 2755

References
Curated References
27 references in RGD related to Smad2

Other References
26 other references at PubMed related to Smad2

Database Information
RGD ID 3031
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

23-OCT-08: Smad2 SMAD family member 2 Smad2 MAD homolog 2 (Drosophila) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

17-NOV-05: Smad2 MAD homolog 2 (Drosophila) APPROVED Symbol updated 1299863

10-JUN-02: Madh2 MAD homolog 2 (Drosophila) APPROVED Name updated 70584