Smad2 (SMAD family member 2) - Rat Genome Database

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Pathways
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Gene: Smad2 (SMAD family member 2) Ictidomys tridecemlineatus
Analyze
Symbol: Smad2
Name: SMAD family member 2
RGD ID: 12478367
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); transcription factor binding (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); cell fate commitment (ortholog); PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH acromicric dysplasia (ortholog); breast carcinoma (ortholog); cervical cancer (ortholog); FOUND IN heteromeric SMAD protein complex (ortholog); homomeric SMAD protein complex (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mothers against decapentaplegic homolog 2; SMAD family member 2, transcript variant X1; SMAD family member 2, transcript variant X2; SMAD family member 2, transcript variant X3; SMAD family member 2, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649714,723,199 - 14,801,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IEA)
adrenal gland development  (ISO)
anatomical structure morphogenesis  (IEA)
anterior/posterior pattern specification  (IEA,ISO)
aortic valve morphogenesis  (IEA)
cell differentiation  (IEA)
cell fate commitment  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
determination of left/right asymmetry in lateral mesoderm  (IEA)
developmental growth  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic foregut morphogenesis  (IEA,ISO)
embryonic pattern specification  (IEA,ISO)
endocardial cushion morphogenesis  (IEA)
endoderm development  (IEA,ISO)
endoderm formation  (IEA,ISO)
gastrulation  (IEA,ISO)
heart development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
insulin secretion  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
lung development  (IEA,ISO)
mesoderm formation  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of gene expression  (IEA,ISO)
nodal signaling pathway  (IEA)
odontoblast differentiation  (IEA)
organ growth  (IEA,ISO)
pancreas development  (IEA,ISO)
paraxial mesoderm morphogenesis  (IEA,ISO)
pattern specification process  (IEA,ISO)
pericardium development  (IEA,ISO)
positive regulation of BMP signaling pathway  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
post-embryonic development  (IEA,ISO)
pulmonary valve morphogenesis  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of transforming growth factor beta receptor signaling pathway  (IEA)
response to cholesterol  (IEA)
response to glucose  (IEA,ISO)
response to transforming growth factor beta  (IEA,ISO)
secondary palate development  (IEA)
signal transduction involved in regulation of gene expression  (ISO)
SMAD protein signal transduction  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
ureteric bud development  (IEA)
zygotic specification of dorsal/ventral axis  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Smad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649714,723,199 - 14,801,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381847,808,957 - 47,930,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1847,808,957 - 47,931,146 (-)EnsemblGRCh38hg38GRCh38
GRCh371845,335,328 - 45,457,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361843,613,464 - 43,711,510 (-)NCBINCBI36Build 36hg18NCBI36
Build 341843,618,434 - 43,710,924NCBI
Celera1842,208,816 - 42,306,655 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1842,208,822 - 42,306,925 (-)NCBIHuRef
CHM1_11845,354,416 - 45,452,506 (-)NCBICHM1_1
T2T-CHM13v2.01847,999,960 - 48,121,861 (-)NCBIT2T-CHM13v2.0
Smad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391876,369,898 - 76,444,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1876,374,651 - 76,444,034 (+)EnsemblGRCm39 Ensembl
GRCm381876,241,090 - 76,311,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1876,241,580 - 76,310,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv371876,401,579 - 76,465,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361876,367,290 - 76,431,096 (+)NCBIMGSCv36mm8
Celera1877,499,761 - 77,546,271 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1851.42NCBI
Smad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81872,124,792 - 72,193,345 (+)NCBIGRCr8
mRatBN7.21869,849,884 - 69,918,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1869,850,377 - 69,912,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,959,978 - 72,021,908 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01872,629,252 - 72,691,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01870,485,797 - 70,547,727 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01872,550,107 - 72,612,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1872,550,219 - 72,612,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01871,672,879 - 71,735,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41873,180,520 - 73,241,707 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11873,253,792 - 73,314,980 (+)NCBI
Celera1868,381,756 - 68,443,610 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
Smad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540233,136,778 - 33,216,844 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540233,131,760 - 33,217,144 (-)NCBIChiLan1.0ChiLan1.0
SMAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21765,367,623 - 65,457,402 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11851,053,093 - 51,150,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01841,213,001 - 41,309,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11844,572,213 - 44,669,008 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1844,580,905 - 44,668,530 (-)Ensemblpanpan1.1panPan2
SMAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,696,883 - 43,778,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,700,445 - 43,769,983 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,181,631 - 43,262,778 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,649,238 - 43,731,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,649,269 - 43,723,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,350,952 - 43,432,066 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,405,083 - 43,486,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,688,637 - 43,769,813 (+)NCBIUU_Cfam_GSD_1.0
SMAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl197,415,716 - 97,511,357 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1197,415,360 - 97,511,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21106,898,131 - 106,991,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11833,017,138 - 33,105,320 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1833,017,492 - 33,104,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660507,285,525 - 7,381,371 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477811,384,769 - 11,501,078 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477811,380,656 - 11,460,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000003791   ⟹   ENSSTOP00000003397
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493649714,723,199 - 14,801,697 (+)Ensembl
RefSeq Acc Id: XM_005323082   ⟹   XP_005323139
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725027   ⟹   XP_021580702
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,221 - 14,812,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725028   ⟹   XP_021580703
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,221 - 14,812,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725029   ⟹   XP_021580704
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,650 (+)NCBI
SpeTri2.0NW_00493649714,723,220 - 14,812,160 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005323139   ⟸   XM_005323082
- Peptide Label: isoform X1
- UniProtKB: I3M2Z7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580704   ⟸   XM_021725029
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021580702   ⟸   XM_021725027
- Peptide Label: isoform X1
- UniProtKB: I3M2Z7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580703   ⟸   XM_021725028
- Peptide Label: isoform X1
- UniProtKB: I3M2Z7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000003397   ⟸   ENSSTOT00000003791
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003788 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003791.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
NCBI Gene Smad2 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2 UniProtKB/TrEMBL
  PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt I3M2Z7 ENTREZGENE, UniProtKB/TrEMBL