Lepr (leptin receptor) - Rat Genome Database

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Gene: Lepr (leptin receptor) Rattus norvegicus
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Symbol: Lepr
Name: leptin receptor
RGD ID: 3001
Description: Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of behavior; and positive regulation of cell communication. Located in extracellular space. Used to study several diseases, including chronic kidney disease; congestive heart failure (multiple); glucose metabolism disease (multiple); obesity; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor); PARTICIPATES IN leptin system pathway; altered leptin system pathway; obesity pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fa; LEP-R; Leptin receptor (fatty); OB receptor; OB-R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lepr_v2   Lepr_v1   Leprem2Mcwi   Leprm1Rll   Leprcp   Leprem1   Leprem2   Leprem3   Leprfa   Leprem4Lizh  
Genetic Models: BN.ZUC-Leprfa LA-cp/NRll ZUC-Leprfa ZUC-LeprfaSte-/- SS-Leprem2Mcwi WDF-Leprm1Rll ZDF-Leprm1Rll SD-Leprem3 SD-Leprem2 SD-Leprem1
Is Marker For: Strains:   ZUC-Lepr+Ste   KZ-LeprfaTky   F344.ZUC-Leprfa/Tj   ZDF-LeprfaCrlCrlj   ZDF-Leprfa/Crl   F344.ZUC-(Leprfa),OLETF-(D14Rat23-D14Rat12)/Tj   Slc:ZUC-Leprfa-/-   Ho:ZFDM-Leprfa   ZDF-Leprfa/Drt   SS.ZUC-Leprfa-/+/Slc   SS.ZUC-Leprfa+/+/Slc   Slc:ZUC-Leprfa+  
Candidate Gene For: Bss4 Bw146
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85121,409,735 - 121,593,201 (+)NCBIGRCr8
mRatBN7.25116,294,409 - 116,477,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,289,823 - 116,475,908 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5118,847,763 - 119,019,098 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,573,106 - 120,744,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,624,429 - 120,795,760 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05120,503,475 - 120,682,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,564,645 - 120,682,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05124,380,327 - 124,525,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05124,555,678 - 124,556,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,320,075 - 122,503,449NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5114,817,255 - 114,982,861 (+)NCBICelera
RH 3.4 Map5 RGD
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Albuminuria  (ISO)
Animal Disease Models  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (IMP)
chronic obstructive pulmonary disease  (ISO)
cognitive disorder  (ISO)
congenital disorder of glycosylation It  (ISO)
congenital leptin deficiency  (ISO)
congestive heart failure  (IAGP,ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Delayed Puberty  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IAGP,ISO)
diabetic neuropathy  (ISO)
Diastolic Dysfunction  (IAGP)
diastolic heart failure  (IAGP)
dilated cardiomyopathy  (ISO)
Dyslipidemias  (IMP,ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP)
familial hyperlipidemia  (ISO)
Female Infertility  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
glucose intolerance  (IMP,ISO)
granulosa cell tumor  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (IMP,ISO)
hyperinsulinism  (IMP,ISO)
Hyperphagia  (IAGP,IMP,ISO)
hypertension  (IAGP,IMP,ISO)
hypogonadism  (ISO)
infertility  (ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (IAGP,ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (IMP)
Leptin Receptor Deficiency  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO,ISS)
Metabolic Syndrome  (IAGP)
morbid obesity  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP)
Nasal Polyps  (ISO)
nephritis  (ISO)
obesity  (IAGP,IMP,ISO,ISS)
obstructive sleep apnea  (ISO)
osteoporosis  (ISO)
Overweight  (ISO)
pancreas disease  (ISO)
pancreatitis  (IAGP)
pituitary gland disease  (ISO)
Pneumococcal Pneumonia  (ISO)
pre-eclampsia  (IEP)
Precocious Puberty  (ISO)
primary biliary cholangitis  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
proteinuria  (IAGP,IMP,ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (IMP)
Respiratory Tract Infections  (ISO)
Right Ventricular Hypertrophy  (ISO)
short bowel syndrome  (IEP)
sleep apnea  (ISO)
Spinal Fractures  (ISO)
steatotic liver disease  (ISO)
type 2 diabetes mellitus  (IAGP,ISO,ISS)
Varicose Ulcer  (ISO)
Ventricular Dysfunction, Left  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(N(omega)-L-arginino)succinic acid  (ISO)
(R)-carnitine  (ISO)
(R)-pantothenic acid  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1-methylnicotinamide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxy-4-methylvaleric acid  (ISO)
2-hydroxyisobutyric acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-4-chlorophenoxybutyric acid  (EXP)
2-oxoadipic acid  (ISO)
3-methyl-2-oxobutanoic acid  (ISO)
3-methyl-2-oxovaleric acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allantoin  (ISO)
allethrin  (EXP)
allopurinol  (EXP)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astaxanthin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromodichloromethane  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
captopril  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
citric acid  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
coumestrol  (ISO)
creatinine  (ISO)
crocidolite asbestos  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyromazine  (EXP)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
diquat  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
ethylmalonic acid  (ISO)
fentin chloride  (EXP)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formic acid  (ISO)
fructose  (EXP)
fumaric acid  (ISO)
furan  (EXP)
galactaric acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutaric acid  (ISO)
glutathione  (EXP)
glycidol  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
gypenoside LXXV  (ISO)
harmine  (ISO)
hesperidin  (ISO)
hexanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (ISO)
indoxyl sulfate  (ISO)
isobutyric acid  (ISO)
isocaproic acid  (ISO)
isoprenaline  (EXP,ISO)
isovaleric acid  (ISO)
ketamine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP)
LY294002  (ISO)
malonic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methylmalonic acid  (ISO)
methylmercury chloride  (ISO)
metyrapone  (EXP)
mifepristone  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-6-pyridone-3-carboxamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP)
Nicotinamide N-oxide  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
orotic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pioglitazone  (EXP,ISO)
pirimicarb  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propranolol  (EXP)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
razoxane  (EXP)
resveratrol  (ISO)
riddelliine  (EXP)
rotenone  (EXP)
rutin  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
succinic acid  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
superoxide  (ISO)
tacrine  (EXP)
taurine  (ISO)
telmisartan  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
urea  (ISO)
valeric acid  (ISO)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,IMP,ISO,ISS)
bone growth  (IEA,ISO,ISS)
cellular response to acetate  (IEP)
cellular response to butyrate  (IEP)
cholesterol metabolic process  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,IEA)
eating behavior  (IMP)
energy homeostasis  (IEA,ISO,ISS)
female pregnancy  (IEP)
generation of precursor metabolites and energy  (NAS)
glial cell proliferation  (IEA,ISO)
gluconeogenesis  (IEA,ISO)
glucose homeostasis  (IEA,ISO,ISS)
glycogen metabolic process  (IEA,ISO)
leptin-mediated signaling pathway  (IDA,IEA,ISO)
male gonad development  (IEP)
negative regulation of autophagy  (IEA,ISO,ISS)
negative regulation of eating behavior  (IMP)
negative regulation of gluconeogenesis  (IEA,ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of locomotor rhythm  (IMP)
ovulation from ovarian follicle  (IEP)
phagocytosis  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IBA)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of protein phosphorylation  (ISO)
regulation of bone remodeling  (IEA,ISO,ISS)
regulation of feeding behavior  (IEA,ISO,ISS)
regulation of transport  (IEA,ISO)
response to dexamethasone  (IEP)
response to estrogen  (IEP)
response to hypoxia  (IEP)
response to leptin  (IEP,ISO)
response to lipid  (IEP)
response to nicotine  (IEP)
response to nutrient  (IEP)
sexual reproduction  (IEA,ISO,ISS)
T cell differentiation  (IEA,ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aortic valve flow  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal collagen level  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal glomerular filtration barrier morphology  (IMP)
abnormal heart left ventricle pressure  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal white adipose tissue mass  (IAGP)
albuminuria  (IAGP)
arteriosclerosis  (IAGP)
decreased bone mineral density  (IMP)
decreased creatinine clearance  (IAGP)
decreased energy expenditure  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased renal plasma flow rate  (IAGP)
decreased survivor rate  (IAGP)
decreased trabecular bone volume  (IMP)
dilated renal tubule  (IAGP)
expanded mesangial matrix  (IAGP,IMP)
glomerulosclerosis  (IAGP,IMP)
heart left ventricle hypertrophy  (IAGP)
hepatic steatosis  (IAGP,IMP)
hyperlipidemia  (IAGP)
hypertension  (IAGP,IMP)
impaired exercise endurance  (IAGP)
impaired glucose tolerance  (IMP)
increased blood urea nitrogen level  (IAGP)
increased body mass index  (IAGP)
increased body weight  (IAGP,IMP)
increased bone trabecular spacing  (IMP)
increased circulating alanine transaminase level  (IAGP,IMP)
increased circulating aspartate transaminase level  (IMP)
increased circulating cholesterol level  (IAGP,IMP)
increased circulating creatinine level  (IMP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IMP)
increased circulating insulin level  (IAGP,IMP)
increased circulating LDL cholesterol level  (IMP)
increased circulating leptin level  (IAGP,IMP)
increased circulating triglyceride level  (IAGP,IMP)
increased collagen deposition in the muscles  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased fat cell size  (IMP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased heart left ventricle anterior wall thickness  (IAGP)
increased heart left ventricle weight  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased renal vascular resistance  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP,IMP)
increased triglyceride level  (IAGP)
increased urine flow rate  (IAGP)
increased urine lipocalin 2 level  (IAGP)
increased urine microalbumin level  (IAGP)
increased urine protein level  (IAGP,IMP)
increased white adipose tissue mass  (IAGP)
increased white fat cell number  (IAGP)
insulin resistance  (IMP)
muscle weakness  (IAGP)
obese  (IAGP)
pancreas fibrosis  (IMP)
pancreas hyperplasia  (IMP)
podocyte foot process effacement  (IMP)
polyphagia  (IAGP)
pulmonary vascular congestion  (IAGP)
renal cast  (IAGP)
renal glomerulus fibrosis  (IAGP)
renal glomerulus hypertrophy  (IAGP)
renal interstitial fibrosis  (IAGP,IMP)
renal tubule atrophy  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Nicotinamide for the treatment of heart failure with preserved ejection fraction. Abdellatif M, etal., Sci Transl Med. 2021 Feb 10;13(580):eabd7064. doi: 10.1126/scitranslmed.abd7064.
2. Progression of pancreatitis prior to diabetes onset in WBN/Kob-Lepr(fa) rats. Akimoto T, etal., J Vet Med Sci. 2012 Jan;74(1):65-70. Epub 2011 Aug 12.
3. Leptin Receptor Gene Polymorphisms and the Risk of Non-Alcoholic Fatty Liver Disease and Coronary Atherosclerosis in the Chinese Han Population. An BQ, etal., Hepat Mon. 2016 Apr 27;16(4):e35055. doi: 10.5812/hepatmon.35055. eCollection 2016 Apr.
4. Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. Anderson CM, etal., Am J Obstet Gynecol. 2005 Jul;193(1):267-72.
5. Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System. Bao D, etal., Sci Rep. 2015 Nov 5;5:15942. doi: 10.1038/srep15942.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. Bienertova-Vasku JA, etal., Heart Vessels. 2009 Mar;24(2):131-7. Epub 2009 Apr 1.
8. Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet. Boado RJ, etal., J Neurochem. 1998 Oct;71(4):1761-4.
9. Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene. Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.
10. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. de Luca C, etal., J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.
11. Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2. de Luis DA, etal., Diabetes Res Clin Pract. 2008 Sep;81(3):e9-e11. Epub 2008 Jul 15.
12. Influence of Lys656Asn polymorphism of the leptin receptor gene on insulin resistance in nondiabetic obese patients. de Luis DA, etal., J Diabetes Complications. 2008 May-Jun;22(3):199-204. Epub 2008 Apr 16.
13. Leptin receptor blockade reduces intrahepatic vascular resistance and portal pressure in an experimental model of rat liver cirrhosis. Delgado MG, etal., Am J Physiol Gastrointest Liver Physiol. 2013 Oct 1;305(7):G496-502. doi: 10.1152/ajpgi.00336.2012. Epub 2013 Jul 25.
14. Leptin modulates the expression of its receptors in the hypothalamic-pituitary-ovarian axis in a differential way. Di Yorio MP, etal., J Endocrinol. 2008 Aug;198(2):355-66. Epub 2008 May 30.
15. High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy. Dower K, etal., PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.
16. Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. Fairbrother UL, etal., J Bone Miner Res. 2007 Apr;22(4):544-50.
17. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. Farooqi IS, etal., N Engl J Med. 2007 Jan 18;356(3):237-47.
18. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Fortuno A, etal., Endocrinology 2002 Sep;143(9):3555-60.
19. ObRa and ObRe are differentially expressed in adipose tissue in aged food-restricted rats: effects on circulating soluble leptin receptor levels. Gallardo N, etal., Endocrinology. 2005 Nov;146(11):4934-42. Epub 2005 Jul 21.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Grill HJ, etal., Endocrinology 2002 Jan;143(1):239-46.
23. Leptin receptor polymorphisms and lung function decline in COPD. Hansel NN, etal., Eur Respir J. 2009 Jul;34(1):103-10. Epub 2009 Feb 5.
24. Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat. Hattori T, etal., Nutr Diabetes. 2011 Jan 31;1:e1. doi: 10.1038/nutd.2010.1.
25. Leptin potentiates thermogenic sympathetic responses to hypothermia: a receptor-mediated effect. Hausberg M, etal., Diabetes. 2002 Aug;51(8):2434-40.
26. 41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model. Homer BL and Dower K, Toxicol Pathol. 2018 Dec;46(8):976-977. doi: 10.1177/0192623318803278. Epub 2018 Oct 3.
27. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Hommel JD, etal., Neuron. 2006 Sep 21;51(6):801-10.
28. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
29. Modulation of circulating leptin levels by its soluble receptor. Huang L, etal., J Biol Chem 2001 Mar 2;276(9):6343-9.
30. Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Iida M, etal., Biochem Biophys Res Commun 1996 Jul 16;224(2):597-604.
31. Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Iida M, etal., Biochem Biophys Res Commun 1996 May 6;222(1):19-26.
32. Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Irani BG, etal., Endocrinology. 2007 Jan;148(1):310-6. Epub 2006 Oct 5.
33. Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Iversen PO, etal., Blood 2002 Dec 1;100(12):4123-8.
34. Leptin Promotes Fibroproliferative ARDS by Inhibiting Peroxisome Proliferator-activated Receptor-{gamma} Jain M, etal., Am J Respir Crit Care Med. 2011 Feb 11.
35. Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. Jang MH, etal., Brain Res. 2003 Feb 28;964(2):311-5.
36. Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. Kanoski SE, etal., Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E496-503. doi: 10.1152/ajpendo.00205.2012. Epub 2012 Jun 12.
37. Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. Karlsson EA, etal., J Nutr. 2010 Sep;140(9):1691-7. Epub 2010 Jun 30.
38. Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. Kim K, etal., Physiol Genomics. 2010 Feb 16.
39. Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus. Koga S, etal., Neurosci Lett. 2014 Jun 13;571:11-6. doi: 10.1016/j.neulet.2014.04.028. Epub 2014 Apr 28.
40. Fat diet affects leptin receptor levels in the rat cerebellum. Koros C, etal., Nutrition. 2009 Jan;25(1):85-7. Epub 2008 Aug 27.
41. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
42. Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Ladyman SR and Grattan DR, Endocrinology. 2005 Sep;146(9):3868-74. Epub 2005 May 19.
43. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. Lee Y, etal., J Biol Chem 2001 Feb 23;276(8):5629-35.
44. Leptin receptor isoform expression in rat osteoblasts and their functional analysis. Lee YJ, etal., FEBS Lett 2002 Sep 25;528(1-3):43-7.
45. Role of leptin receptor (LEPR) gene polymorphisms and haplotypes in susceptibility to hepatocellular carcinoma in subjects with chronic hepatitis B virus infection. Li Z, etal., Mol Diagn Ther. 2012 Dec;16(6):383-8. doi: 10.1007/s40291-012-0008-1.
46. A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat. Lopez M, etal., Diabetologia. 2005 Jan;48(1):140-8. Epub 2004 Dec 23.
47. Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. Lu H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):228-32. Epub 2008 Aug 17.
48. [Association of single nucleotide polymorphisms (SNPs) in leptin receptor gene with knee osteoarthritis in the Ningxia Hui population]. Ma XJ, etal., Yi Chuan. 2013 Mar;35(3):359-64.
49. Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. Mancuso P, etal., J Immunol. 2011 Jan 15;186(2):1081-90. Epub 2010 Dec 10.
50. Soluble leptin receptor and insulin resistance as determinant of sleep apnea. Manzella D, etal., Int J Obes Relat Metab Disord. 2002 Mar;26(3):370-5.
51. Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
52. Impaired response of UCP family to cold exposure in diabetic (db/db) mice. Masaki T, etal., Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1305-9. doi: 10.1152/ajpregu.2000.279.4.R1305.
53. Ischemia/reperfusion in rat heart induces leptin and leptin receptor gene expression. Matsui H, etal., Life Sci. 2007 Jan 23;80(7):672-80. Epub 2006 Nov 10.
54. Leptin signalling reduces the severity of cardiac dysfunction and remodelling after chronic ischaemic injury. McGaffin KR, etal., Cardiovasc Res. 2008 Jan;77(1):54-63. Epub 2007 Sep 20.
55. Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
56. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Meli R, etal., Endocrinology. 2004 Jul;145(7):3115-21. Epub 2004 Apr 1.
57. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
58. Leptin receptors are developmentally regulated in rat pituitary and hypothalamus. Morash BA, etal., Mol Cell Endocrinol. 2003 Nov 28;210(1-2):1-8.
59. A short form of leptin receptor performs signal transduction. Murakami T, etal., Biochem Biophys Res Commun. 1997 Feb 3;231(1):26-9.
60. Polymorphism of the 3'-untranslated region of the leptin receptor gene, but not the adiponectin SNP45 polymorphism, predicts type 2 diabetes: a population-based study. Nannipieri M, etal., Diabetes Care. 2006 Nov;29(11):2509-11.
61. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
62. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
63. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Park HY, etal., Exp Mol Med. 2001 Jun 30;33(2):95-102.
64. Induction of specific microRNAs inhibits cutaneous wound healing. Pastar I, etal., J Biol Chem. 2012 Aug 24;287(35):29324-35. doi: 10.1074/jbc.M112.382135. Epub 2012 Jul 6.
65. Leptin receptor missense mutation in the fatty Zucker rat. Phillips MS, etal., Nat Genet 1996 May;13(1):18-9.
66. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
67. Frequency of distribution of leptin receptor gene polymorphism in obstructive sleep apnea patients. Popko K, etal., J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 2):551-61.
68. Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats. Poudel B, etal., Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1489-F1499. doi: 10.1152/ajprenal.00100.2020. Epub 2020 May 11.
69. Rat heart is a site of leptin production and action. Purdham DM, etal., Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2877-84. Epub 2004 Jul 29.
70. A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart. Purdham DM, etal., Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H441-6. Epub 2008 May 9.
71. The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese. Qu Y, etal., Diabetes Res Clin Pract. 2008 Jul;81(1):33-7. Epub 2008 Apr 24.
72. GOA pipeline RGD automated data pipeline
73. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
74. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
75. Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity. Rolland V, etal., Obes Res. 1998 Mar;6(2):122-7.
76. Hypertension in obesity and the leptin receptor gene locus. Rosmond R, etal., J Clin Endocrinol Metab. 2000 Sep;85(9):3126-31.
77. Leptin and leptin receptor expression in the rat ovary. Ryan NK, etal., Endocrinology. 2003 Nov;144(11):5006-13. Epub 2003 Aug 14.
78. ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction. Schauer A, etal., ESC Heart Fail. 2020 Oct;7(5):2123-2134. doi: 10.1002/ehf2.12915. Epub 2020 Jul 25.
79. Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. Shih CD, etal., J Biomed Sci. 2003 Jul-Aug;10(4):367-78.
80. Leptin receptor expression in the rat placenta: changes in ob-ra, ob-rb, and ob-re with gestational age and suppression by glucocorticoids. Smith JT and Waddell BJ, Biol Reprod. 2002 Oct;67(4):1204-10.
81. Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue. Song SY, etal., Laryngoscope. 2010 May;120(5):1046-50.
82. Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. Stefanou N, etal., BMC Cancer. 2010 Aug 19;10:442. doi: 10.1186/1471-2407-10-442.
83. Leptin receptor isoforms mRNA expression in peripheral blood mononuclear cells from patients with chronic viral hepatitis. Stefanou N, etal., Exp Biol Med (Maywood). 2006 Nov;231(10):1653-63. doi: 10.1177/153537020623101011.
84. Hyperphagia as a mediator of renal disease initiation in obese Zucker rats. Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
85. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat. Sukhotnik I, etal., Pediatr Res. 2009 Dec;66(6):648-53.
86. Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor. Swellam M and Hamdy N, IUBMB Life. 2012 Feb;64(2):180-6. doi: 10.1002/iub.597. Epub 2012 Jan 3.
87. Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis. Szalay F, etal., Eur J Gastroenterol Hepatol. 2005 Sep;17(9):923-8.
88. Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Sánchez-Margalet V, etal., Clin Exp Immunol. 2002 Jul;129(1):119-24. doi: 10.1046/j.1365-2249.2002.01900.x.
89. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Takaya K, etal., Nat Genet. 1996 Oct;14(2):130-1.
90. Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats. Tamasi JA, etal., J Bone Miner Res. 2003 Sep;18(9):1605-11.
91. Developmental and hormonal regulation of leptin receptor (Ob-R) messenger ribonucleic acid expression in rat testis. Tena-Sempere M, etal., Biol Reprod. 2001 Feb;64(2):634-43.
92. Renal function and structure in diabetic, hypertensive, obese ZDFxSHHF-hybrid rats. Tofovic SP, etal., Ren Fail. 2000;22(4):387-406. doi: 10.1081/jdi-100100882.
93. Specific increase in leptin production in obese (falfa) rat adipose cells. Turban S, etal., Biochem J 2002 Feb 15;362(Pt 1):113-8.
94. Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. Wang MY, etal., Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11921-6.
95. Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease. Wu N, etal., Anatol J Cardiol. 2018 Jun;19(6):360-367. doi: 10.14744/AnatolJCardiol.2018.23682.
96. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Wu-Peng XS, etal., Diabetes. 1997 Mar;46(3):513-8.
97. Leptin receptor signal transduction: OBRa and OBRb of fa type. Yamashita T, etal., Biochem Biophys Res Commun. 1998 May 29;246(3):752-9.
98. Association of polymorphisms in the leptin and leptin receptor genes with inflammatory mediators in patients with osteoporosis. Ye XL and Lu CF, Endocrine. 2013 Oct;44(2):481-8. doi: 10.1007/s12020-013-9899-9. Epub 2013 Mar 5.
99. Effects of acetate and butyrate on the expression of leptin and short-form leptin receptor in bovine and rat anterior pituitary cells. Yonekura S, etal., Gen Comp Endocrinol. 2003 Sep;133(2):165-72.
100. Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene. Zain SM, etal., J Gastroenterol Hepatol. 2013 May;28(5):873-9. doi: 10.1111/jgh.12104.
Additional References at PubMed
PMID:8690163   PMID:8769097   PMID:8772180   PMID:9268737   PMID:9438411   PMID:9732873   PMID:10660043   PMID:11165038   PMID:11344130   PMID:11786145   PMID:12010881   PMID:12021059  
PMID:12594516   PMID:12606446   PMID:15995171   PMID:16116438   PMID:16328017   PMID:16962144   PMID:16964413   PMID:17038325   PMID:17218441   PMID:17391913   PMID:17611900   PMID:17951546  
PMID:18250539   PMID:18563836   PMID:18719678   PMID:18782535   PMID:19082917   PMID:19094094   PMID:19403617   PMID:19422379   PMID:19479985   PMID:19591986   PMID:19596404   PMID:19726710  
PMID:19726711   PMID:19747514   PMID:19877509   PMID:19996157   PMID:20171169   PMID:20347812   PMID:20501326   PMID:20600421   PMID:20691166   PMID:20963574   PMID:20977476   PMID:21158112  
PMID:21180167   PMID:21257164   PMID:21334312   PMID:21452040   PMID:21454707   PMID:21457721   PMID:21771332   PMID:21946196   PMID:22038286   PMID:22715380   PMID:22875962   PMID:22968639  
PMID:23028249   PMID:23304119   PMID:23382219   PMID:23549406   PMID:23576026   PMID:23669042   PMID:23782941   PMID:24007473   PMID:24013029   PMID:24051374   PMID:24291064   PMID:24903921  
PMID:24905621   PMID:24920667   PMID:25060689   PMID:25380550   PMID:25383904   PMID:26122392   PMID:26408544   PMID:26702900   PMID:27037668   PMID:28717967   PMID:28759941   PMID:28973665  
PMID:29568885   PMID:30133304   PMID:30269202   PMID:30339059   PMID:31702041   PMID:35198097   PMID:35271883   PMID:37730735  


Genomics

Comparative Map Data
Lepr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85121,409,735 - 121,593,201 (+)NCBIGRCr8
mRatBN7.25116,294,409 - 116,477,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,289,823 - 116,475,908 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5118,847,763 - 119,019,098 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,573,106 - 120,744,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,624,429 - 120,795,760 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05120,503,475 - 120,682,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,564,645 - 120,682,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05124,380,327 - 124,525,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05124,555,678 - 124,556,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,320,075 - 122,503,449NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5114,817,255 - 114,982,861 (+)NCBICelera
RH 3.4 Map5 RGD
Cytogenetic Map5q33NCBI
LEPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,420,652 - 65,641,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,420,652 - 65,641,559 (+)EnsemblGRCh38hg38GRCh38
GRCh37165,886,335 - 66,107,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,658,906 - 65,875,410 (+)NCBINCBI36Build 36hg18NCBI36
Build 34165,598,338 - 65,814,843NCBI
Celera164,176,916 - 64,393,787 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef163,995,123 - 64,212,195 (+)NCBIHuRef
CHM1_1166,002,606 - 66,219,234 (+)NCBICHM1_1
T2T-CHM13v2.0165,298,629 - 65,519,352 (+)NCBIT2T-CHM13v2.0
Lepr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,574,393 - 101,676,375 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,574,601 - 101,672,549 (+)EnsemblGRCm39 Ensembl
GRCm384101,717,137 - 101,815,352 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,717,404 - 101,815,352 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,390,012 - 101,487,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364101,215,371 - 101,313,237 (+)NCBIMGSCv36mm8
Celera4100,061,452 - 100,155,523 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.96NCBI
Lepr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542325,111,266 - 25,185,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542325,108,897 - 25,185,315 (-)NCBIChiLan1.0ChiLan1.0
LEPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21161,226,191 - 161,441,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,386,446 - 160,592,001 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,772,612 - 64,881,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1166,651,994 - 66,764,768 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl166,693,926 - 66,764,768 (+)Ensemblpanpan1.1panPan2
LEPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1544,684,118 - 44,775,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,688,109 - 44,775,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha544,745,719 - 44,810,649 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0544,870,825 - 44,963,640 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl544,875,468 - 44,963,183 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1544,840,852 - 44,906,048 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0544,786,008 - 44,851,055 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0545,029,763 - 45,094,688 (-)NCBIUU_Cfam_GSD_1.0
Lepr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,634,973 - 78,718,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365915,774,326 - 5,836,444 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365915,771,371 - 5,846,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6146,801,954 - 146,895,995 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16146,802,297 - 146,896,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LEPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12067,454,205 - 67,567,524 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2067,454,334 - 67,524,229 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603349,988,602 - 50,125,048 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lepr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474229,223,392 - 29,337,049 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474229,221,742 - 29,313,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lepr
1336 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:96
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000044131, ENSRNOT00000050597
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
D5Wox38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,360,112 - 116,360,293 (+)MAPPERmRatBN7.2
Rnor_6.05120,569,168 - 120,569,348NCBIRnor6.0
Rnor_5.05124,446,252 - 124,446,432UniSTSRnor5.0
RGSC_v3.45122,386,495 - 122,386,675UniSTSRGSC3.4
Celera5114,882,835 - 114,883,015UniSTS
Cytogenetic Map5q33UniSTS
D5Wox37  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05120,566,555 - 120,566,842NCBIRnor6.0
Rnor_5.05124,443,639 - 124,443,926UniSTSRnor5.0
RGSC_v3.45122,383,882 - 122,384,169UniSTSRGSC3.4
Celera5114,880,222 - 114,880,509UniSTS
Cytogenetic Map5q33UniSTS
D5Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,368,606 - 116,368,754 (+)MAPPERmRatBN7.2
Rnor_6.05120,577,662 - 120,577,809NCBIRnor6.0
Rnor_5.05124,454,745 - 124,454,892UniSTSRnor5.0
RGSC_v3.45122,394,986 - 122,395,133UniSTSRGSC3.4
Celera5114,891,327 - 114,891,474UniSTS
Cytogenetic Map5q33UniSTS
D5Rhw23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,292,445 - 116,292,656 (+)MAPPERmRatBN7.2
Rnor_6.05120,501,513 - 120,501,723NCBIRnor6.0
Rnor_5.05124,378,365 - 124,378,575UniSTSRnor5.0
RGSC_v3.45122,318,113 - 122,318,323UniSTSRGSC3.4
Celera5114,815,293 - 114,815,503UniSTS
Cytogenetic Map5q33UniSTS
RH129126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,301,426 - 116,301,929 (+)MAPPERmRatBN7.2
Rnor_6.05120,510,487 - 120,510,989NCBIRnor6.0
Rnor_5.05124,387,687 - 124,388,189UniSTSRnor5.0
RGSC_v3.45122,327,396 - 122,327,898UniSTSRGSC3.4
Celera5114,824,241 - 114,824,743UniSTS
RH 3.4 Map5787.8UniSTS
Cytogenetic Map5q33UniSTS
RH94807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,403,395 - 116,403,535 (+)MAPPERmRatBN7.2
Rnor_6.05120,612,273 - 120,612,412NCBIRnor6.0
Rnor_5.05124,488,768 - 124,488,907UniSTSRnor5.0
RGSC_v3.45122,433,750 - 122,433,889UniSTSRGSC3.4
Celera5114,926,233 - 114,926,372UniSTS
RH 3.4 Map5803.7UniSTS
Cytogenetic Map5q33UniSTS
AU048762  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera5114,903,630 - 114,903,747UniSTS
Cytogenetic Map5q33UniSTS


Related Rat Strains
The following Strains have been annotated to Lepr
F344.ZUC-(Leprfa),OLETF-(D14Rat23-D14Rat12)/Tj     F344.ZUC-Leprfa/Tj     Ho:ZFDM-Leprfa     KZ-LeprfaTky     Slc:ZUC-Leprfa+     Slc:ZUC-Leprfa-/-     SS.ZUC-Leprfa+/+/Slc     SS.ZUC-Leprfa-/+/Slc     ZDF-LeprfaCrlCrlj     ZDF-Leprfa/Crl     ZDF-Leprfa/Drt     ZUC-Lepr+Ste    


Genetic Models
This gene Lepr is modified in the following models/strains:
BN.ZUC-Leprfa     LA-cp/NRll     ZUC-Leprfa     ZUC-LeprfaSte-/-     SS-Leprem2Mcwi     WDF-Leprm1Rll     ZDF-Leprm1Rll     SD-Leprem3     SD-Leprem2     SD-Leprem1    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB011006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC129815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF139208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF287268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5116,294,409 - 116,475,908 (+)Ensembl
Rnor_6.0 Ensembl5120,577,975 - 120,682,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050597   ⟹   ENSRNOP00000045398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5116,359,187 - 116,450,411 (+)Ensembl
Rnor_6.0 Ensembl5120,568,242 - 120,652,220 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,646,516 - 120,680,609 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,567,822 - 120,581,390 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5116,289,823 - 116,472,969 (+)Ensembl
Rnor_6.0 Ensembl5120,568,020 - 120,652,253 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,564,645 - 120,585,228 (+)Ensembl
RefSeq Acc Id: NM_012596   ⟹   NP_036728
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,409,735 - 121,591,213 (+)NCBI
mRatBN7.25116,294,409 - 116,475,906 (+)NCBI
Rnor_6.05120,503,475 - 120,682,281 (+)NCBI
Rnor_5.05124,380,327 - 124,525,200 (+)NCBI
Rnor_5.05124,555,678 - 124,556,585 (+)NCBI
RGSC_v3.45122,320,075 - 122,503,449 (+)RGD
Celera5114,817,255 - 114,982,861 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109264   ⟹   XP_038965192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,473,931 - 121,593,201 (+)NCBI
mRatBN7.25116,358,875 - 116,477,904 (+)NCBI
RefSeq Acc Id: XM_039109265   ⟹   XP_038965193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,473,930 - 121,593,201 (+)NCBI
mRatBN7.25116,358,603 - 116,477,904 (+)NCBI
RefSeq Acc Id: XM_039109266   ⟹   XP_038965194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,473,954 - 121,565,752 (+)NCBI
mRatBN7.25116,358,879 - 116,451,540 (+)NCBI
RefSeq Acc Id: XM_039109267   ⟹   XP_038965195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,473,953 - 121,589,539 (+)NCBI
mRatBN7.25116,358,879 - 116,474,232 (+)NCBI
RefSeq Acc Id: XM_063287157   ⟹   XP_063143227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,473,953 - 121,565,752 (+)NCBI
RefSeq Acc Id: XM_063287158   ⟹   XP_063143228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,473,953 - 121,589,539 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001416383 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416388 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416389 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416390 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416391 (Get FASTA)   NCBI Sequence Viewer  
  NP_036728 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965192 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965193 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965194 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965195 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143227 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143228 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB03088 (Get FASTA)   NCBI Sequence Viewer  
  AAB06616 (Get FASTA)   NCBI Sequence Viewer  
  AAB40654 (Get FASTA)   NCBI Sequence Viewer  
  AAB63201 (Get FASTA)   NCBI Sequence Viewer  
  AAB63202 (Get FASTA)   NCBI Sequence Viewer  
  AAC52587 (Get FASTA)   NCBI Sequence Viewer  
  AAF61190 (Get FASTA)   NCBI Sequence Viewer  
  AAF61191 (Get FASTA)   NCBI Sequence Viewer  
  AAF61192 (Get FASTA)   NCBI Sequence Viewer  
  AAF63410 (Get FASTA)   NCBI Sequence Viewer  
  AAF89300 (Get FASTA)   NCBI Sequence Viewer  
  AAG22823 (Get FASTA)   NCBI Sequence Viewer  
  BAA12230 (Get FASTA)   NCBI Sequence Viewer  
  BAA12231 (Get FASTA)   NCBI Sequence Viewer  
  BAA12697 (Get FASTA)   NCBI Sequence Viewer  
  BAA12698 (Get FASTA)   NCBI Sequence Viewer  
  BAA12830 (Get FASTA)   NCBI Sequence Viewer  
  BAA12831 (Get FASTA)   NCBI Sequence Viewer  
  BAA12832 (Get FASTA)   NCBI Sequence Viewer  
  BAA24899 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045398.5
  ENSRNOP00000080721.1
  ENSRNOP00000093122.1
GenBank Protein Q62959 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036728   ⟸   NM_012596
- Peptide Label: precursor
- UniProtKB: A0A8I5ZQD9 (UniProtKB/TrEMBL),   A6JRP2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045398   ⟸   ENSRNOT00000050597
RefSeq Acc Id: XP_038965193   ⟸   XM_039109265
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQD9 (UniProtKB/TrEMBL),   A6JRP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965192   ⟸   XM_039109264
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965195   ⟸   XM_039109267
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965194   ⟸   XM_039109266
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143228   ⟸   XM_063287158
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063143227   ⟸   XM_063287157
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62959-F1-model_v2 AlphaFold Q62959 1-1162 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693869
Promoter ID:EPDNEW_R4386
Type:initiation region
Name:Lepr_2
Description:leptin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4387  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05120,567,819 - 120,567,879EPDNEW
RGD ID:13693862
Promoter ID:EPDNEW_R4387
Type:initiation region
Name:Lepr_1
Description:leptin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4386  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05120,568,306 - 120,568,366EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3001 AgrOrtholog
BioCyc Gene G2FUF-40533 BioCyc
Ensembl Genes ENSRNOG00000023664 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044131.8 UniProtKB/TrEMBL
  ENSRNOT00000050597.6 UniProtKB/TrEMBL
  ENSRNOT00000093574.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEP-R_IGD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type-I_Cytokine_Rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24536 UniProtKB/Swiss-Prot
NCBI Gene 24536 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOTACTIN FORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lep_receptor_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ObR_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LEPR RGD
PhenoGen Lepr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023664 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJP1 ENTREZGENE, UniProtKB/TrEMBL
  A6JRP2 ENTREZGENE, UniProtKB/TrEMBL
  A6JRP6_RAT UniProtKB/TrEMBL
  A6JRP8_RAT UniProtKB/TrEMBL
  F1M9F2 ENTREZGENE, UniProtKB/TrEMBL
  LEPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O35772 UniProtKB/Swiss-Prot
  O35773 UniProtKB/Swiss-Prot
  O54805 UniProtKB/Swiss-Prot
  P70493 UniProtKB/Swiss-Prot
  P70494 UniProtKB/Swiss-Prot
  P70495 UniProtKB/Swiss-Prot
  P97589 UniProtKB/Swiss-Prot
  Q62960 UniProtKB/Swiss-Prot
  Q63007 UniProtKB/Swiss-Prot
  Q63385 UniProtKB/Swiss-Prot
  Q63386 UniProtKB/Swiss-Prot
  Q9ERI4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Lepr  leptin receptor    leptin receptor   Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Lepr  leptin receptor       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the endothelial cells of the vascular wall 625675
gene_function receptor for obesity factor (leptin) 61790
gene_process protects nonadipocytes from the adverse consequences of lipid overaccumulation 62400
gene_product member of the gp130 family of cytokine receptors that stimulate gene transcription via activation of cytosolic STAT proteins 61790
gene_protein an isoform exists with a short intracellular domain 729196
gene_transcript two isoforms of the mRNA were detected 625675