RGD Reference Report - Leptin receptor signaling in midbrain dopamine neurons regulates feeding. - Rat Genome Database

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Leptin receptor signaling in midbrain dopamine neurons regulates feeding.

Authors: Hommel, JD  Trinko, R  Sears, RM  Georgescu, D  Liu, ZW  Gao, XB  Thurmon, JJ  Marinelli, M  DiLeone, RJ 
Citation: Hommel JD, etal., Neuron. 2006 Sep 21;51(6):801-10.
RGD ID: 10412019
Pubmed: PMID:16982424   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuron.2006.08.023   (Journal Full-text)

The leptin hormone is critical for normal food intake and metabolism. While leptin receptor (Lepr) function has been well studied in the hypothalamus, the functional relevance of Lepr expression in the ventral tegmental area (VTA) has not been investigated. The VTA contains dopamine neurons that are important in modulating motivated behavior, addiction, and reward. Here, we show that VTA dopamine neurons express Lepr mRNA and respond to leptin with activation of an intracellular JAK-STAT pathway and a reduction in firing rate. Direct administration of leptin to the VTA caused decreased food intake while long-term RNAi-mediated knockdown of Lepr in the VTA led to increased food intake, locomotor activity, and sensitivity to highly palatable food. These data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA dopamine neurons.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of eating behavior  IMP 10412019 RGD 
negative regulation of locomotor rhythm  IMP 10412019 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lepr  (leptin receptor)


Additional Information