Ins1 (insulin 1) - Rat Genome Database

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Gene: Ins1 (insulin 1) Rattus norvegicus
Analyze
Symbol: Ins1
Name: insulin 1
RGD ID: 2915
Description: Enables insulin receptor binding activity. Involved in several processes, including cellular response to glucose stimulus; response to cAMP; and response to dimethyl sulfoxide. Located in extracellular space. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin); PARTICIPATES IN insulin signaling pathway; aldosterone signaling pathway; autophagy pathway; INTERACTS WITH (+)-catechin; (R)-adrenaline; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Insulin; insulin-1
RGD Orthologs
Human
Mouse
Squirrel
Alliance Orthologs
More Info more info ...
Candidate Gene For: Scl67 Stl31 Iddm21
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81261,186,119 - 261,186,686 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1261,186,119 - 261,186,682 (+)EnsemblGRCr8
mRatBN7.21251,244,973 - 251,245,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1251,244,973 - 251,245,536 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1259,368,906 - 259,369,473 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01266,074,993 - 266,075,560 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01258,728,428 - 258,728,995 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01272,799,784 - 272,800,351 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1272,799,784 - 272,800,347 (+)Ensemblrn6Rnor6.0
Rnor_5.01280,213,615 - 280,214,182 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41258,001,134 - 258,001,688 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1246,946,414 - 246,946,981 (+)NCBICelera
RGSC_v3.11258,267,212 - 258,267,545 (+)NCBI
RH 3.4 Map11654.9RGD
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pronuciferine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(aminooxy)acetic acid  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-carnitine  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R)-pantothenic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,4-dithiothreitol  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2-(4-hydroxyphenyl)ethanol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (EXP)
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid  (ISO)
2-deoxy-D-glucose  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-Dimethylbisphenol A  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-aminobenzoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-O-methyl-D-glucose  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-2-oxopentanoic acid  (ISO)
4-methylcatechol  (EXP)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7-nitroindazole  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-phenanthrol  (EXP)
AACOCF3  (EXP)
acarbose  (EXP)
acephate  (EXP)
acetate ester  (EXP)
acetylleucyl-leucyl-norleucinal  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (ISO)
all-trans-retinol  (ISO)
allopurinol  (EXP)
alloxan  (EXP,ISO)
allyl isothiocyanate  (EXP)
alpha-(methylamino)isobutyric acid  (EXP)
alpha-D-galactose  (EXP)
alpha-Zearalanol  (ISO)
AM-251  (ISO)
amino acid  (ISO)
aminophylline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthranilic acid  (EXP)
apigenin  (EXP,ISO)
apocynin  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP,ISO)
astaxanthin  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
avobenzone  (ISO)
Azoxymethane  (ISO)
bafilomycin A1  (ISO)
baicalin  (EXP)
Bay-K-8644  (EXP,ISO)
benazepril  (EXP)
benzamide  (ISO)
benzamides  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP)
Betanin  (EXP)
bezafibrate  (EXP)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
boric acid  (ISO)
Bromoenol lactone  (EXP)
budesonide  (EXP)
bumetanide  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
C-peptide  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
capsaicin  (EXP,ISO)
captan  (ISO)
carbachol  (EXP,ISO)
CARBENOXOLONE  (EXP)
carbon nanotube  (ISO)
carnosine  (ISO)
carvacrol  (EXP)
celastrol  (ISO)
celecoxib  (EXP)
Chebulagic acid  (EXP)
chicoric acid  (EXP)
chlorothalonil  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium(3+) trichloride  (EXP)
chromium(6+)  (EXP)
chrysin  (EXP)
citronellol  (EXP)
cobalt atom  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (EXP)
corilagin  (EXP)
corn oil  (EXP)
cortisol  (EXP)
costunolide  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cytochalasin B  (EXP,ISO)
D-glucitol  (EXP)
D-glucose  (EXP,ISO)
D-glyceraldehyde  (EXP)
D-ribofuranose  (ISO)
dactolisib  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (EXP)
dehydroepiandrosterone  (EXP)
Deoxycorticosterone acetate  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
diazoxide  (EXP,ISO)
dichlorvos  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dimercaprol  (ISO)
dimethylarsinous acid  (ISO)
diosgenin  (EXP)
disodium cromoglycate  (ISO)
disodium selenite  (EXP,ISO)
dorsomorphin  (EXP,ISO)
duvoglustat  (ISO)
ebselen  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (EXP)
Eremanthin  (EXP)
ethanol  (EXP,ISO)
Evodiamine  (ISO)
fenofibrate  (EXP)
ferric ammonium citrate  (ISO)
ferrostatin-1  (ISO)
finasteride  (EXP)
fisetin  (ISO)
flunarizine  (EXP)
fluticasone  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructooligosaccharide  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
galactose  (EXP)
gallic acid  (EXP)
gallocatechin  (ISO)
gamma-aminobutyric acid  (EXP)
gatifloxacin  (EXP)
genistein  (EXP,ISO)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginsenoside Re  (EXP)
Ginsenoside Rh4  (EXP,ISO)
gliclazide  (EXP)
glimepiride  (EXP)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP,ISO)
glyceraldehyde  (EXP)
glycerol 2-phosphate  (ISO)
glycine  (ISO)
glycogen  (EXP)
glycyrrhizinic acid  (ISO)
harmine  (ISO)
heptachlor  (EXP)
herbimycin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (EXP)
hydrogen peroxide  (EXP)
hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester  (EXP)
hydroxytyrosol  (EXP)
imidacloprid  (EXP,ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
isoflavones  (EXP)
isoliquiritigenin  (ISO)
Isosteviol  (ISO)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lamotrigine  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lenalidomide  (EXP)
letrozole  (EXP,ISO)
linagliptin  (EXP)
linsidomine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
lithium carbonate  (EXP)
lutein  (EXP)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mangiferin  (EXP,ISO)
manumycin A  (EXP)
melatonin  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylarsonite  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mitogen  (EXP)
Mitoquinone  (EXP)
MK-2206  (ISO)
molybdate  (EXP)
molybdenum atom  (ISO)
molybdenum trioxide  (ISO)
monensin A  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP)
myricetin  (EXP)
myrtenal  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-phosphocreatine  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naproxen  (EXP,ISO)
naringin  (EXP,ISO)
nerolidol  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP)
Nonylphenol  (EXP)
norwogonin  (EXP)
Octicizer  (ISO)
ofloxacin  (EXP)
oleanolic acid  (EXP)
oleic acid  (EXP,ISO)
orlistat  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
Palbinone  (EXP)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
Pervanadate  (EXP)
phenethyl caffeate  (ISO)
phenylarsine oxide  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picolinic acid  (EXP)
pimobendan  (EXP)
pioglitazone  (EXP,ISO)
piperine  (EXP)
plumbagin  (EXP)
potassium atom  (ISO)
potassium chloride  (EXP,ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
pravastatin  (EXP,ISO)
probenecid  (EXP)
procymidone  (ISO)
progesterone  (ISO)
psoralen  (EXP)
pterostilbene  (ISO)
pyrroloquinoline quinone  (ISO)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (EXP)
quinoxyfen  (ISO)
rac-lactic acid  (EXP)
raffinose  (EXP,ISO)
raloxifene  (ISO)
Repaglinide  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 31-8220  (EXP,ISO)
royal jelly  (EXP)
Rutamarin  (ISO)
rutin  (EXP)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP)
selenium atom  (ISO)
sertraline  (EXP)
sildenafil citrate  (ISO)
silibinin  (ISO)
sirolimus  (EXP,ISO)
sodium acetate trihydrate  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium chloride  (EXP)
sodium fluoride  (ISO)
spironolactone  (EXP)
staurosporine  (EXP,ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sulpiride  (EXP)
sumatriptan  (EXP)
superoxide  (EXP)
tacrolimus hydrate  (EXP)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
theaflavin  (ISO)
theophylline  (EXP)
thiacloprid  (ISO)
thiophanate-methyl  (ISO)
thymoquinone  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tolazamide  (EXP)
tolbutamide  (ISO)
trans-rhaponticin  (EXP)
trelagliptin  (ISO)
tributylstannane  (EXP,ISO)
trichostatin A  (EXP)
triclosan  (ISO)
triflumizole  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(picolinato)chromium  (EXP)
troglitazone  (ISO)
U-73122  (ISO)
umbelliferone  (EXP)
Ursonic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vildagliptin  (EXP)
vitamin E  (EXP,ISO)
Voglibose  (EXP,ISO)
warfarin  (EXP)
wogonin  (EXP)
wortmannin  (EXP,ISO)
YM-254890  (ISO)
zinc atom  (EXP,ISO)
zinc molecular entity  (EXP)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. Arias AE, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2075-83.
2. Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression. Chin-Chance CV, etal., J Investig Med. 2006 Apr;54(3):132-42.
3. Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping. Collinet M, etal., Eur J Pediatr. 1998 Jun;157(6):456-60.
4. Growth promoting peptides in osteoarthritis: insulin, insulin-like growth factor-1, growth hormone. Denko CW, etal., J Rheumatol. 1990 Sep;17(9):1217-21.
5. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Egido EM, etal., Eur J Endocrinol 2002 Feb;146(2):241-4.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Lupinus albus Conglutin Gamma Modifies the Gene Expressions of Enzymes Involved in Glucose Hepatic Production In Vivo. González-Santiago AE, etal., Plant Foods Hum Nutr. 2017 Jun;72(2):134-140. doi: 10.1007/s11130-016-0597-7.
9. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. Grunblatt E, etal., J Neurochem. 2007 May;101(3):757-70.
10. Proinsulin processing in the diabetic Goto-Kakizaki rat. Guest PC, etal., J Endocrinol. 2002 Dec;175(3):637-47.
11. Transient changes in four GLUT4 compartments in rat adipocytes during the transition, insulin-stimulated to basal: implications for the GLUT4 trafficking pathway. Hah JS, etal., Biochemistry 2002 Dec 3;41(48):14364-71.
12. Myosin 5a controls insulin granule recruitment during late-phase secretion. Ivarsson R, etal., Traffic. 2005 Nov;6(11):1027-35.
13. Effects of glucagon-like peptide-1 (GLP-1) in RINm5F insulinoma cells. Stimulation of insulin secretion, insulin content, and insulin receptor binding. Jehle PM, etal., Exp Clin Endocrinol Diabetes. 1995;103 Suppl 2:31-6.
14. Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
15. Regulation of rat pancreatic CCKB receptor and somatostatin expression by insulin. Julien S, etal., Diabetes 2004 Jun;53(6):1526-34.
16. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. Kaneto H, etal., J Biol Chem 2002 Apr 12;277(15):12998-3006.
17. Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications. Kemp DM and Habener JF, Biochem Pharmacol. 2002 Aug 15;64(4):689-97.
18. Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes. Krause U, etal., Eur J Biochem 2002 Aug;269(15):3742-50.
19. Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure. Kuwahata M, etal., Biochim Biophys Acta. 2007 Jan;1772(1):60-5. Epub 2006 Oct 4.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Le Stunff C, etal., Nat Genet. 2000 Dec;26(4):444-6.
22. The structure of rat preproinsulin genes. Lomedico PT, etal., Ann N Y Acad Sci 1980;343:425-32.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Testosterone effect on insulin content, messenger ribonucleic acid levels, promoter activity, and secretion in the rat. Morimoto S, etal., Endocrinology 2001 Apr;142(4):1442-7.
25. Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Naslund E, etal., Regul Pept 2002 Jun 15;106(1-3):89-95.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells. Nitert MD, etal., J Mol Endocrinol. 2008 Jul;41(1):1-11. doi: 10.1677/JME-07-0133.
28. A variant insulin promoter in non-insulin-dependent diabetes mellitus. Olansky L, etal., J Clin Invest. 1992 May;89(5):1596-602.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Parallel signaling pathways of melatonin in the pancreatic beta-cell. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):184-91.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Insulin preincubation effects on rat vessel contractile responses: role of the endothelium. Rebolledo A, etal., Endothelium 2001;8(4):269-76.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Discrimination between signaling pathways in regulation of specific gene expression by insulin and growth hormone in hepatocytes. Ribaux P, etal., Endocrinology 2002 Oct;143(10):3766-72.
37. The levels of Pdx1/insulin, Cacna1c and Cacna1d, and β-cell mass in a rat model of intrauterine undernutrition. Xu YP, etal., J Matern Fetal Neonatal Med. 2011 Mar;24(3):437-43. doi: 10.3109/14767058.2010.497571. Epub 2010 Sep 27.
38. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
39. Study on the mechanism of hepatocytic insulin signal transduction defects in severely scalded rats Zhang B, etal., Zhonghua Shao Shang Za Zhi 2002 Aug;18(4):220-2.
Additional References at PubMed
PMID:325648   PMID:358198   PMID:498283   PMID:498284   PMID:4311938   PMID:4554104   PMID:4640931   PMID:11824480   PMID:11884412   PMID:12038757   PMID:12120208   PMID:12771145  
PMID:12914929   PMID:12928442   PMID:14707149   PMID:14976144   PMID:15068957   PMID:15093702   PMID:15161751   PMID:15466647   PMID:15466888   PMID:15564337   PMID:15632182   PMID:15637161  
PMID:15687408   PMID:15833775   PMID:15899886   PMID:15983214   PMID:15983215   PMID:16553787   PMID:16597920   PMID:16717097   PMID:16909201   PMID:16933034   PMID:17023527   PMID:17068290  
PMID:17127041   PMID:17170237   PMID:17273787   PMID:17292859   PMID:17327422   PMID:17454971   PMID:17550999   PMID:17715136   PMID:17906111   PMID:17982240   PMID:17993259   PMID:18039179  
PMID:18063688   PMID:18165568   PMID:18450959   PMID:19008912   PMID:19194835   PMID:19375131   PMID:19375767   PMID:19549853   PMID:19671839   PMID:19728324   PMID:20225168   PMID:20571033  
PMID:20668029   PMID:20857410   PMID:20886068   PMID:21149828   PMID:21332026   PMID:21402379   PMID:21454690   PMID:21773965   PMID:21792084   PMID:21911493   PMID:22002008   PMID:22065581  
PMID:22119580   PMID:22319612   PMID:22715380   PMID:22750144   PMID:22996137   PMID:23016131   PMID:23016132   PMID:23703573   PMID:24084692   PMID:24425760   PMID:24425765   PMID:24440707  
PMID:24569992   PMID:24894193   PMID:25011481   PMID:25159330   PMID:25232145   PMID:25961284   PMID:26449460   PMID:26632509   PMID:26775660   PMID:26882284   PMID:26986474   PMID:27336168  
PMID:27495870   PMID:28084108   PMID:28188284   PMID:28237718   PMID:28359774   PMID:28410130   PMID:28689409   PMID:29952285   PMID:30112574   PMID:30879761   PMID:31257494   PMID:32325912  
PMID:32631952   PMID:35562179  


Genomics

Comparative Map Data
Ins1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81261,186,119 - 261,186,686 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1261,186,119 - 261,186,682 (+)EnsemblGRCr8
mRatBN7.21251,244,973 - 251,245,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1251,244,973 - 251,245,536 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1259,368,906 - 259,369,473 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01266,074,993 - 266,075,560 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01258,728,428 - 258,728,995 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01272,799,784 - 272,800,351 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1272,799,784 - 272,800,347 (+)Ensemblrn6Rnor6.0
Rnor_5.01280,213,615 - 280,214,182 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41258,001,134 - 258,001,688 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1246,946,414 - 246,946,981 (+)NCBICelera
RGSC_v3.11258,267,212 - 258,267,545 (+)NCBI
RH 3.4 Map11654.9RGD
Cytogenetic Map1q55NCBI
INS-IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,129,117 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,132,538 - 2,161,209 (-)Ensemblhg38GRCh38
GRCh37112,150,347 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,926 - 2,139,015 (-)NCBIBuild 36Build 36hg18NCBI36
Celera112,186,841 - 2,218,946 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,940,864 - 1,972,702 (-)NCBIHuRef
CHM1_1112,148,968 - 2,181,387 (-)NCBICHM1_1
T2T-CHM13v2.0112,216,758 - 2,248,857 (-)NCBIT2T-CHM13v2.0
Ins1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391952,252,735 - 52,253,453 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1952,252,735 - 52,253,914 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381952,264,297 - 52,265,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1952,264,297 - 52,265,476 (+)Ensemblmm10GRCm38
MGSCv371952,338,813 - 52,339,966 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361952,317,762 - 52,318,343 (+)NCBIMGSCv36mm8
Celera1954,451,492 - 54,452,645 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1946.76NCBI
LOC120889510
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,733,854 - 1,743,304 (-)NCBIHiC_Itri_2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:41
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000016052
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
D1Ztm5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,258,770 - 251,259,068 (+)MAPPERmRatBN7.2
Rnor_6.01272,813,582 - 272,813,879NCBIRnor6.0
Rnor_5.01280,227,413 - 280,227,710UniSTSRnor5.0
RGSC_v3.41258,014,919 - 258,015,216UniSTSRGSC3.4
Celera1246,960,238 - 246,960,535UniSTS
Cytogenetic Map1q54-q55UniSTS
D1Ztm4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,246,901 - 251,247,066 (+)MAPPERmRatBN7.2
Rnor_6.01272,801,713 - 272,801,877NCBIRnor6.0
Rnor_5.01280,215,544 - 280,215,708UniSTSRnor5.0
RGSC_v3.41258,003,050 - 258,003,214UniSTSRGSC3.4
Celera1246,948,343 - 246,948,533UniSTS
Cytogenetic Map1q54-q55UniSTS
D1Ztm6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,260,995 - 251,261,233 (+)MAPPERmRatBN7.2
Rnor_6.01272,815,807 - 272,816,044NCBIRnor6.0
Rnor_5.01280,229,638 - 280,229,875UniSTSRnor5.0
RGSC_v3.41258,017,144 - 258,017,381UniSTSRGSC3.4
Celera1246,962,465 - 246,962,707UniSTS
Cytogenetic Map1q54-q55UniSTS
D1Ztm3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,246,810 - 251,247,089 (+)MAPPERmRatBN7.2
Rnor_6.01272,801,622 - 272,801,900NCBIRnor6.0
Rnor_5.01280,215,453 - 280,215,731UniSTSRnor5.0
RGSC_v3.41258,002,959 - 258,003,237UniSTSRGSC3.4
Celera1246,948,252 - 246,948,556UniSTS
Cytogenetic Map1q54-q55UniSTS
AA986540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,377 - 251,245,516 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,189 - 272,800,327NCBIRnor6.0
Rnor_5.01280,214,020 - 280,214,158UniSTSRnor5.0
RGSC_v3.41258,001,526 - 258,001,664UniSTSRGSC3.4
Celera1246,946,819 - 246,946,957UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC123023P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,426 - 197,844,133 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,183 - 251,245,392 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,995 - 272,800,203NCBIRnor6.0
Rnor_6.01215,857,117 - 215,857,823NCBIRnor6.0
Rnor_5.01280,213,826 - 280,214,034UniSTSRnor5.0
Rnor_5.01222,751,936 - 222,752,642UniSTSRnor5.0
RGSC_v3.41202,935,638 - 202,936,344UniSTSRGSC3.4
RGSC_v3.41258,001,332 - 258,001,540UniSTSRGSC3.4
Celera1246,946,625 - 246,946,833UniSTS
Celera1195,461,459 - 195,462,165UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21231P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,360 - 197,844,160 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,156 - 251,245,457 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,968 - 272,800,268NCBIRnor6.0
Rnor_6.01215,857,051 - 215,857,850NCBIRnor6.0
Rnor_5.01280,213,799 - 280,214,099UniSTSRnor5.0
Rnor_5.01222,751,870 - 222,752,669UniSTSRnor5.0
RGSC_v3.41202,935,572 - 202,936,371UniSTSRGSC3.4
RGSC_v3.41258,001,305 - 258,001,605UniSTSRGSC3.4
Celera1246,946,598 - 246,946,898UniSTS
Celera1195,461,393 - 195,462,192UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21334P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,378 - 197,844,106 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,210 - 251,245,439 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,022 - 272,800,250NCBIRnor6.0
Rnor_6.01215,857,069 - 215,857,796NCBIRnor6.0
Rnor_5.01280,213,853 - 280,214,081UniSTSRnor5.0
Rnor_5.01222,751,888 - 222,752,615UniSTSRnor5.0
RGSC_v3.41202,935,590 - 202,936,317UniSTSRGSC3.4
RGSC_v3.41258,001,359 - 258,001,587UniSTSRGSC3.4
Celera1246,946,652 - 246,946,880UniSTS
Celera1195,461,411 - 195,462,138UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,160 - 251,245,460 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,972 - 272,800,271NCBIRnor6.0
Rnor_5.01280,213,803 - 280,214,102UniSTSRnor5.0
RGSC_v3.41258,001,309 - 258,001,608UniSTSRGSC3.4
Celera1246,946,602 - 246,946,901UniSTS
Cytogenetic Map1q54-q55UniSTS
RH94799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,380 - 197,844,179 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,137 - 251,245,437 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,949 - 272,800,248NCBIRnor6.0
Rnor_6.01215,857,071 - 215,857,869NCBIRnor6.0
Rnor_5.01280,213,780 - 280,214,079UniSTSRnor5.0
Rnor_5.01222,751,890 - 222,752,688UniSTSRnor5.0
RGSC_v3.41202,935,592 - 202,936,390UniSTSRGSC3.4
RGSC_v3.41258,001,286 - 258,001,585UniSTSRGSC3.4
Celera1246,946,579 - 246,946,878UniSTS
Celera1195,461,413 - 195,462,211UniSTS
RH 3.4 Map11654.9UniSTS
Cytogenetic Map1q54-q55UniSTS
Cytogenetic Map1q41UniSTS
PMC123023P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,148 - 251,245,480 (+)MAPPERmRatBN7.2
mRatBN7.21197,843,337 - 197,844,168 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,028 - 215,857,858NCBIRnor6.0
Rnor_6.01272,799,960 - 272,800,291NCBIRnor6.0
Rnor_5.01280,213,791 - 280,214,122UniSTSRnor5.0
Rnor_5.01222,751,847 - 222,752,677UniSTSRnor5.0
RGSC_v3.41202,935,549 - 202,936,379UniSTSRGSC3.4
RGSC_v3.41258,001,297 - 258,001,628UniSTSRGSC3.4
Celera1246,946,590 - 246,946,921UniSTS
Celera1195,461,370 - 195,462,200UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC24644P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,343 - 197,844,030 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,286 - 251,245,474 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,098 - 272,800,285NCBIRnor6.0
Rnor_6.01215,857,034 - 215,857,720NCBIRnor6.0
Rnor_5.01280,213,929 - 280,214,116UniSTSRnor5.0
Rnor_5.01222,751,853 - 222,752,539UniSTSRnor5.0
RGSC_v3.41202,935,555 - 202,936,241UniSTSRGSC3.4
RGSC_v3.41258,001,435 - 258,001,622UniSTSRGSC3.4
Celera1246,946,728 - 246,946,915UniSTS
Celera1195,461,376 - 195,462,062UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
UniSTS:267003  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,338 - 197,844,055 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,261 - 251,245,479 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,073 - 272,800,290NCBIRnor6.0
Rnor_6.01215,857,029 - 215,857,745NCBIRnor6.0
Rnor_5.01280,213,904 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,564UniSTSRnor5.0
RGSC_v3.41202,935,550 - 202,936,266UniSTSRGSC3.4
RGSC_v3.41258,001,410 - 258,001,627UniSTSRGSC3.4
Celera1246,946,703 - 246,946,920UniSTS
Celera1195,461,371 - 195,462,087UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,159 - 251,245,461 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,971 - 272,800,272NCBIRnor6.0
Rnor_5.01280,213,802 - 280,214,103UniSTSRnor5.0
RGSC_v3.41258,001,308 - 258,001,609UniSTSRGSC3.4
Celera1246,946,601 - 246,946,902UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,338 - 197,844,149 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,167 - 251,245,479 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,979 - 272,800,290NCBIRnor6.0
Rnor_6.01215,857,029 - 215,857,839NCBIRnor6.0
Rnor_5.01280,213,810 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,658UniSTSRnor5.0
RGSC_v3.41258,001,316 - 258,001,627UniSTSRGSC3.4
RGSC_v3.41202,935,550 - 202,936,360UniSTSRGSC3.4
Celera1246,946,609 - 246,946,920UniSTS
Celera1195,461,371 - 195,462,181UniSTS
Cytogenetic Map1q54-q55UniSTS
Cytogenetic Map1q41UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,333 - 251,245,517 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,145 - 272,800,328NCBIRnor6.0
Rnor_5.01280,213,976 - 280,214,159UniSTSRnor5.0
RGSC_v3.41258,001,482 - 258,001,665UniSTSRGSC3.4
Celera1246,946,775 - 246,946,958UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 1 10 14 12 9 11 9 31 12 12 8 20 3

Sequence


Ensembl Acc Id: ENSRNOT00000016052   ⟹   ENSRNOP00000016052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1261,186,119 - 261,186,682 (+)Ensembl
mRatBN7.2 Ensembl1251,244,973 - 251,245,536 (+)Ensembl
Rnor_6.0 Ensembl1272,799,784 - 272,800,347 (+)Ensembl
RefSeq Acc Id: NM_019129   ⟹   NP_062002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81261,186,119 - 261,186,686 (+)NCBI
mRatBN7.21251,244,973 - 251,245,540 (+)NCBI
Rnor_6.01272,799,784 - 272,800,351 (+)NCBI
Rnor_5.01280,213,615 - 280,214,182 (+)NCBI
RGSC_v3.41258,001,134 - 258,001,688 (+)RGD
Celera1246,946,414 - 246,946,981 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062002 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41439 (Get FASTA)   NCBI Sequence Viewer  
  AAA41442 (Get FASTA)   NCBI Sequence Viewer  
  CAA24559 (Get FASTA)   NCBI Sequence Viewer  
  EDL94407 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016052
  ENSRNOP00000016052.3
GenBank Protein P01322 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062002   ⟸   NM_019129
- Peptide Label: preproprotein
- UniProtKB: P01322 (UniProtKB/Swiss-Prot),   A6JHT2 (UniProtKB/TrEMBL),   A6JHT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016052   ⟸   ENSRNOT00000016052
Protein Domains
Insulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01322-F1-model_v2 AlphaFold P01322 1-110 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850044
Promoter ID:EP11131
Type:single initiation site
Name:RN_INS1
Description:Insulin I, INS1 or INS-1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 45; Mammalian insulin
Tissues & Cell Lines:pancreas islet cells
Experiment Methods:Length measurement of an RNA product; RNA Pol II in vitro system;; low-precision data; Nuclease protection; transfected or transformed cells; Primer extension; transfected or transformed cells; Nuclease protection; experiments performed with closely related; gene; Primer extension; experiments performed with closely related; gene
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41258,001,119 - 258,001,179EPD
RGD ID:13690985
Promoter ID:EPDNEW_R1510
Type:single initiation site
Name:Ins1_1
Description:insulin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01272,799,784 - 272,799,844EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2915 AgrOrtholog
BioCyc Gene G2FUF-55410 BioCyc
Ensembl Genes ENSRNOG00000012052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016052 ENTREZGENE
  ENSRNOT00000016052.6 UniProtKB/Swiss-Prot
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot
InterPro Insulin UniProtKB/Swiss-Prot
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report rno:24505 UniProtKB/Swiss-Prot
NCBI Gene 24505 ENTREZGENE
PANTHER INSULIN UniProtKB/Swiss-Prot
  PTHR11454 UniProtKB/Swiss-Prot
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Ins1 PhenoGen
PRINTS INSULIN UniProtKB/Swiss-Prot
  INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012052 RatGTEx
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt A6JHT1 ENTREZGENE, UniProtKB/TrEMBL
  A6JHT2 ENTREZGENE, UniProtKB/TrEMBL
  INS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Ins1  insulin 1    Insulin  Name updated 625702 APPROVED
2002-06-10 Ins1  Insulin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function recruits GLUT4 to the plasma membrane 727471
gene_function polypeptide hormone and ligand for insulin receptor 625703
gene_process causes rapid and sustained phosphorylation of protein kinase B, induces glucokinase transcription and hypophosphorylates Erk 1 and 2 625703
gene_process involved in carbohydrate metabolism 625703
gene_regulation testosterone administration increases mRNA level and release 625703