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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2915
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins1
Name: insulin 1
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins1affects expressionEXP 6480464CTDGlucose affects the expression of INS1 mRNAPMID:22643931
Ins1affects secretionEXP 6480464CTDGlucose affects the secretion of INS1 proteinPMID:22643931
Ins1decreases abundanceEXP 6480464CTDINS1 protein results in decreased abundance of GlucosePMID:19540215
Ins1decreases expressionEXP 6480464CTDGlucose results in decreased expression of INS1 mRNAPMID:20723550
Ins1decreases secretionEXP 6480464CTDGlucose results in decreased secretion of INS1 proteinPMID:29183753
Ins1increases expressionEXP 6480464CTDGlucose results in increased expression of INS1 proteinPMID:16366736 PMID:28027979 PMID:29165388
Ins1increases metabolic processingEXP 6480464CTDINS1 protein results in increased metabolism of GlucosePMID:30940548 PMID:7498292
Ins1increases secretionEXP 6480464CTDGlucose results in increased secretion of INS1 proteinPMID:10221768 PMID:10623569 PMID:11289044 PMID:11893929 PMID:14578291 PMID:15878969 PMID:15919803 PMID:16413591 PMID:17069794 PMID:17241282 PMID:17339113 PMID:17578889 PMID:17723306 PMID:17922229 PMID:18597805 PMID:19070612 PMID:19071154 PMID:19393637 PMID:19479076 PMID:21319751 PMID:21854074 PMID:21888768 PMID:22872759 PMID:23138875 PMID:23328667 PMID:24349266 PMID:25228148 PMID:25280772 PMID:25343247 PMID:25851902 PMID:27008626 PMID:27317948 PMID:27415824 PMID:27836638 PMID:27939242 PMID:28027979 PMID:28180948 PMID:29098165 PMID:31778773 PMID:32553926 PMID:33359794 PMID:33922211 PMID:35196519 PMID:35199402 PMID:9030901 PMID:9492047 PMID:9662045 PMID:9751766
Ins1increases transportEXP 6480464CTDINS1 protein results in increased transport of GlucosePMID:2185640
Ins1increases uptakeEXP 6480464CTDINS1 protein results in increased uptake of GlucosePMID:17198541 PMID:21394550 PMID:2262933 PMID:25499137 PMID:2645939 PMID:30918868
Ins1multiple interactionsEXP 6480464CTD(+)-JQ1 compound promotes the reaction [Glucose results in increased secretion of INS1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [Glucose results in increased secretion of INS1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; 3-(4-((2',6'-dimethylbiphenyl-3-yl)methoxy)-2-fluorophenyl)propanoic acid promotes the reaction [Glucose results in increased secretion of INS1 protein]; 3-(4-((2,6-dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid promotes the reaction [Glucose results in increased secretion of INS1 protein]; 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene inhibits the reaction [Glucose results in increased secretion of INS1 protein]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; 7-nitroindazole inhibits the reaction [[INS1 protein co-treated with Glucose] results in increased transport of Zinc]; 9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein]; 9-phenanthrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [4-methylcatechol co-treated with Glucose] results in increased secretion of INS1 protein; [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [[valyl-histidyl-threonyl-aspartamide binds to Zinc] results in increased activity of [INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein]] which results in decreased abundance of Glucose; [Alloxan co-treated with Homocysteine] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [GCG protein co-treated with Glucose] results in increased secretion of INS1 protein; [GCG protein modified form binds to and results in increased activity of GLP1R protein] promotes the reaction [Glucose results in increased secretion of INS1 protein]; [Glucose co-treated with 3,4-dihydroxyphenylethanol] results in increased secretion of INS1 protein; [Glucose co-treated with dihydroxyethyldithiocarbamate] results in decreased expression of INS1; [Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate; [Glucose co-treated with INS1 protein] results in increased secretion of LEP protein; [Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein; [Glucose co-treated with Plant Extracts] results in increased secretion of INS1 protein; [IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [INS1 protein co-treated with Glucose] results in increased activity of PARP1 protein; [INS1 protein co-treated with Glucose] results in increased transport of Zinc; [TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; ALB protein modified form inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]; alpha-methylbenzylaminobenzotriazole inhibits the reaction [BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]; arachidonyltrifluoromethane inhibits the reaction [BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; argan oil inhibits the reaction [Glucose results in increased expression of INS1 protein]; Arsenic Trioxide inhibits the reaction [[Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein]; benazepril inhibits the reaction [Glucose results in increased secretion of INS1 protein]; benazepril promotes the reaction [INS1 protein results in increased metabolism of Glucose]; bisphenol A affects the reaction [Glucose results in increased secretion of INS1 protein]; bisphenol A promotes the reaction [Glucose results in increased secretion of INS1 protein]; BL 11282 analog promotes the reaction [Glucose results in increased secretion of INS1 protein]; BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]; Budesonide inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Budesonide inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Bumetanide inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; Cannabidiol promotes the reaction [Glucose results in increased secretion of INS1 protein]; Capsaicin promotes the reaction [Glucose results in increased secretion of INS1 protein]; Chlorpyrifos inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Colchicine inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]; cordycepin promotes the reaction [Glucose results in increased secretion of INS1 protein]; Corn Oil inhibits the reaction [Glucose results in increased expression of INS1 protein]; Cycloheximide inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Dexamethasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; Dietary Fats affects the reaction [INS1 protein results in increased uptake of Glucose]; Dietary Fats inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Diethylhexyl Phthalate inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Diethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased metabolism of Glucose]; Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Exenatide inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Exenatide inhibits the reaction [Palmitic Acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Fluticasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fluticasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Glucosamine inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Glucose inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Glucose inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Homocysteine inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Hydrocortisone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Hydrogen Peroxide inhibits the reaction [Glucose results in increased secretion of INS1 protein]; INS1 protein inhibits the reaction [Dichlorvos results in increased abundance of Glucose]; INS1 protein inhibits the reaction [FOXO1 protein results in increased abundance of Glucose]; INS1 protein promotes the reaction [FOXO1 protein mutant form results in increased abundance of Glucose]; INS1 protein promotes the reaction [Glucose results in increased expression of LEP mRNA]; INS1 protein promotes the reaction [Glucose results in increased secretion of LEP protein]; INS1 protein results in increased transport of and results in increased oxidation of Glucose; KMUP 1 inhibits the reaction [Glucose results in decreased secretion of INS1 protein]; Lenalidomide inhibits the reaction [Arsenic Trioxide inhibits the reaction [[Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein]]; LEP promotes the reaction [Glucose results in increased secretion of INS1 protein]; Manganese deficiency inhibits the reaction [INS1 protein results in increased oxidation of Glucose]; manganese(III)-tetrakis(4-benzoic acid)porphyrin affects the reaction [Glucose affects the expression of INS1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin affects the reaction [Glucose affects the secretion of INS1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; Metformin inhibits the reaction [Glucose results in increased secretion of INS1 protein]; MK615 extract inhibits the reaction [ALB protein modified form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; N-(-4-(N-(biphenyl-2-ylmethyl)-N-2-methylpropylamino)- 1-(2-(2,4-difluorobenzoyl)benzoyl)pyrrolidin- 2-yl)methyl-3-(4-(2,4-dioxothiazolidin-5-ylidenemethyl) phenyl)acrylamide inhibits the reaction [BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Arsenic Trioxide inhibits the reaction [[Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein]]; NFE2L2 protein affects the reaction [Exenatide inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; Niacinamide inhibits the reaction [Glucose results in increased expression of INS1 protein]; nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; nymphayol promotes the reaction [INS1 protein results in increased uptake of Glucose]; Oleic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Palmitic Acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]; pimobendan promotes the reaction [Glucose results in increased secretion of INS1 protein]; PPARA protein promotes the reaction [Glucose results in increased secretion of INS1 protein]; PPARG protein inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Quercetin inhibits the reaction [INS1 protein results in increased transport of and results in increased oxidation of Glucose]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Resveratrol inhibits the reaction [Dietary Fats inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Resveratrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Ro 31-8220 inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Sirolimus inhibits the reaction [Glucose results in increased secretion of INS1 protein]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]; SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein]; SLC30A8 protein affects the reaction [Glucose results in increased secretion of INS1 protein]; SOD1 protein inhibits the reaction [[INS1 protein co-treated with Glucose] results in increased activity of PARP1 protein]; sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]; sodium arsenite promotes the reaction [Glucose results in increased secretion of INS1 protein]; Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Taurine inhibits the reaction [Arsenic Trioxide inhibits the reaction [[Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tetradecanoylphorbol Acetate promotes the reaction [Glucose results in increased secretion of INS1 protein]; TRIB3 protein affects the reaction [INS1 protein results in increased uptake of Glucose]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]; trichostatin A inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Triiodothyronine, Reverse inhibits the reaction [INS1 protein results in increased uptake of Glucose]; tubacin inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; tubacin promotes the reaction [Glucose results in increased secretion of INS1 protein]; UCP2 protein inhibits the reaction [SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein]]; Vitamin E inhibits the reaction [Triiodothyronine, Reverse inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; Wortmannin inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Zinc inhibits the reaction [Glucose results in increased secretion of INS1 protein]PMID:10221768 PMID:10780946 PMID:11289044 PMID:11893929 PMID:1324726 PMID:14578291 PMID:15788402 PMID:15878969 PMID:15919803 PMID:16366736 PMID:16413591 PMID:17069794 PMID:17198541 PMID:17241282 PMID:17339113 PMID:17578889 PMID:17723306 PMID:17922229 PMID:18545258 PMID:18597805 PMID:18669601 PMID:19070612 PMID:19071154 PMID:19393637 PMID:19463741 PMID:19479076 PMID:19492079 PMID:21190014 PMID:21319751 PMID:21394550 PMID:21854074 PMID:2185640 PMID:2204694 PMID:222008 PMID:2262933 PMID:22643931 PMID:22872759 PMID:23138875 PMID:23328667 PMID:24349266 PMID:25228148 PMID:25280772 PMID:25499137 PMID:25851902 PMID:2645939 PMID:27008626 PMID:27317948 PMID:27415824 PMID:27836638 PMID:27939242 PMID:28027979 PMID:28180948 PMID:29098165 PMID:29165388 PMID:29183753 PMID:29473434 PMID:30660605 PMID:30918868 PMID:30940548 PMID:31778773 PMID:32553926 PMID:33359794 PMID:33922211 PMID:35196519 PMID:35199402 PMID:7498292 PMID:9030901 PMID:9453242 PMID:9492047 PMID:9751766
Ins1decreases abundanceISOIns1 (Mus musculus)6480464CTDINS1 protein results in decreased abundance of GlucosePMID:33253011
Ins1decreases chemical synthesisISOIns1 (Mus musculus)6480464CTDINS1 protein results in decreased chemical synthesis of GlucosePMID:31170414
Ins1increases importISOIns1 (Mus musculus)6480464CTDINS1 protein results in increased import of GlucosePMID:20471953
Ins1increases metabolic processingISOIns1 (Mus musculus)6480464CTDINS1 protein results in increased metabolism of GlucosePMID:22415589 PMID:26942597
Ins1increases secretionISOIns1 (Mus musculus)6480464CTDGlucose results in increased secretion of INS1 proteinPMID:10199125 PMID:10464266 PMID:15028607 PMID:15919478 PMID:17922229 PMID:19052259 PMID:19450229 PMID:22479612 PMID:22872759 PMID:23236509 PMID:23795780 PMID:25205820 PMID:25851902 PMID:25859628 PMID:26512966 PMID:26875785 PMID:28180948 PMID:28559246 PMID:29111283 PMID:29161229 PMID:29658312 PMID:30562058 PMID:31095431 PMID:31332465 PMID:31776611 PMID:33038468 PMID:34225579 PMID:34813903 PMID:35457000 PMID:37217659
Ins1increases transportISOIns1 (Mus musculus)6480464CTDINS1 protein results in increased transport of GlucosePMID:18615583
Ins1increases uptakeISOIns1 (Mus musculus)6480464CTDINS1 protein results in increased uptake of Glucose; INS1 results in increased uptake of GlucosePMID:15276423 PMID:15516700 PMID:17520061 PMID:18262572 PMID:18310442 PMID:20406654 PMID:21847688 PMID:22384078 PMID:25543134 PMID:28242381 PMID:33026256
Ins1multiple interactionsISOIns1 (Mus musculus)6480464CTD1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[4-(3-3,4-p-menthadien-(1,8)-yl)olivetol co-treated with Glucose] results in increased secretion of INS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[O-1602 compound co-treated with Glucose] results in increased secretion of INS1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased uptake of Glucose]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [methylarsonite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [Glucose results in increased secretion of INS1 protein]; 7-Ala-angiotensin (1-7) promotes the reaction [Glucose results in increased secretion of INS1 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Acrolein inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Arsenic Trioxide inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; [4-(3-3,4-p-menthadien-(1,8)-yl)olivetol co-treated with Glucose] results in increased secretion of INS1 protein; [arachidonyl-2-chloroethylamide co-treated with Glucose] results in increased secretion of INS1 protein; [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [Carbachol co-treated with Glucose] results in increased secretion of INS1 protein; [Chromium co-treated with Vanadates] promotes the reaction [INS1 protein results in increased uptake of Glucose]; [Chromium Compounds co-treated with Vanadates] promotes the reaction [INS1 protein results in increased uptake of Glucose]; [Dietary Fats affects the susceptibility to INS1 protein] which affects the oxidation of Glucose; [Dietary Fats affects the susceptibility to INS1 protein] which affects the uptake of Glucose; [FFAR1 protein affects the susceptibility to Dietary Fats] affects the reaction [Glucose results in increased secretion of INS1 protein]; [GCG protein modified form binds to and results in increased activity of GLP1R protein] promotes the reaction [Glucose results in increased secretion of INS1 protein]; [Glucose co-treated with Amino Acids] results in increased secretion of INS1 protein; [Glucose co-treated with Dichlorodiphenyl Dichloroethylene] results in increased secretion of INS1 protein; [Glucose co-treated with INS1 protein] affects the expression of KAT6B mRNA; [Glucose co-treated with INS1 protein] affects the expression of KDM1B mRNA; [Glucose co-treated with INS1 protein] affects the expression of KDM4B mRNA; [Glucose co-treated with INS1 protein] affects the localization of PDX1 protein; [GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [lead nitrate results in increased abundance of Lead] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [Mercuric Chloride results in increased abundance of Mercury] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [MME protein results in increased cleavage of angiotensin I (1-7)] affects the reaction [Glucose results in increased secretion of INS1 protein]; [molybdenum trioxide results in increased abundance of Molybdenum] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [O-1602 compound co-treated with Glucose] results in increased secretion of INS1 protein; [Pertussis Toxin co-treated with FR900359] promotes the reaction [Glucose results in increased secretion of INS1 protein]; [Pertussis Toxin co-treated with Glucose] results in increased secretion of INS1 protein; [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; [Tetradecanoylphorbol Acetate co-treated with Glucose] results in increased secretion of INS1 protein; [Tolbutamide co-treated with FR900359] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acrolein inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Adenosine Triphosphate inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Akt-I-1,2 compound inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Akt-I-1,2 compound inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]; AKT1 protein modified form inhibits the reaction [arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; AKT1 protein modified form inhibits the reaction [monomethylarsonous acid inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; angiotensin I (1-7) promotes the reaction [Glucose results in increased secretion of INS1 protein]; Arecoline inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Arsenic Trioxide inhibits the reaction [Estradiol promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Arsenic Trioxide inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Arsenic Trioxide promotes the reaction [Estrogens deficiency inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; arsenite inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [Glucose results in increased secretion of INS1 protein]]; arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]; arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Benzamides promotes the reaction [INS1 protein results in increased uptake of Glucose]; bisphenol A inhibits the reaction [Glucose results in increased secretion of INS1 protein]; bisphenol A inhibits the reaction [INS1 protein results in increased metabolism of Glucose]; bisphenol A promotes the reaction [Glucose results in increased secretion of INS1 protein]; bisphenol S inhibits the reaction [Glucose results in increased secretion of INS1 protein]; BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]; BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]; Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]]; celastrol affects the reaction [[Dietary Fats affects the susceptibility to INS1 protein] which affects the oxidation of Glucose]; celastrol affects the reaction [[Dietary Fats affects the susceptibility to INS1 protein] which affects the uptake of Glucose]; Chromium Compounds promotes the reaction [INS1 protein results in increased uptake of Glucose]; Chromium promotes the reaction [INS1 protein results in increased uptake of Glucose]; cis-9, trans-11-conjugated linoleic acid promotes the reaction [INS1 protein affects the transport of Glucose]; cobaltiprotoporphyrin inhibits the reaction [Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]; copper bis(3,5-diisopropylsalicylate) inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; CYP1A1 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; CYP1A2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Cytochalasin B inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Cytochalasin B inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]; Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Diethylhexyl Phthalate inhibits the reaction [Glucose results in increased secretion of INS1 protein]; dimethylarsine analog inhibits the reaction [INS1 protein results in increased uptake of Glucose]; dimethylarsinous acid inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [Glucose results in increased secretion of INS1 protein]]; dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]; DX600 peptide inhibits the reaction [angiotensin I (1-7) promotes the reaction [Glucose results in increased secretion of INS1 protein]]; DX600 peptide promotes the reaction [Glucose results in increased secretion of INS1 protein]; ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen promotes the reaction [Glucose results in increased secretion of INS1 protein]; Estradiol inhibits the reaction [Arsenic Trioxide promotes the reaction [Estrogens deficiency inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; Estradiol inhibits the reaction [Estrogens deficiency inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Estradiol inhibits the reaction [INS1 protein results in increased transport of Glucose]; Estradiol promotes the reaction [Glucose results in increased secretion of INS1 protein]; Estrogens deficiency inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Exenatide inhibits the reaction [FR900359 inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Exenatide promotes the reaction [Glucose results in increased secretion of INS1 protein]; ferrostatin-1 inhibits the reaction [Acrolein inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; FFAR1 protein affects the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]; FR900359 inhibits the reaction [Exenatide promotes the reaction [Glucose results in increased secretion of INS1 protein]]; FR900359 inhibits the reaction [Glucose results in increased secretion of INS1 protein]; FR900359 inhibits the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]; FR900359 inhibits the reaction [TUG-469 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; FRK protein inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Glyburide inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; GNAI2 gene mutant form inhibits the reaction [[Glucose co-treated with Amino Acids] results in increased secretion of INS1 protein]; GNAI2 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]; GNAQ protein affects the reaction [Glucose results in increased secretion of INS1 protein]; GNAQ protein affects the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]; GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]; IKBKB protein affects the reaction [Particulate Matter promotes the reaction [Glucose results in increased secretion of INS1 protein]]; isosteviol inhibits the reaction [Palmitic Acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; kaempferol promotes the reaction [INS1 protein results in increased uptake of Glucose]; mercaptosteroid 4 inhibits the reaction [Glucose results in increased secretion of INS1 protein]; mercaptosteroid 6 inhibits the reaction [Glucose results in increased secretion of INS1 protein]; methylarsine oxide inhibits the reaction [INS1 protein results in increased uptake of Glucose]; methylarsonite inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [Glucose results in increased secretion of INS1 protein]]; methylarsonite inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein]; MME protein affects the reaction [angiotensin I (1-7) promotes the reaction [Glucose results in increased secretion of INS1 protein]]; mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]; monomethylarsonic acid inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]; naringin inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; naringin promotes the reaction [Glucose results in increased secretion of INS1 protein]; Ozone promotes the reaction [INS1 protein results in decreased abundance of Glucose]; Palmitic Acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]; Particulate Matter promotes the reaction [Glucose results in increased secretion of INS1 protein]; perfluorooctane sulfonic acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Pioglitazone promotes the reaction [INS1 protein results in increased uptake of Glucose]; platyconic acid promotes the reaction [INS1 protein results in increased uptake of Glucose]; POMC inhibits the reaction [INS1 results in increased uptake of Glucose]; Potassium Chloride inhibits the reaction [FR900359 inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Potassium Chloride promotes the reaction [Glucose results in increased secretion of INS1 protein]; Progesterone inhibits the reaction [INS1 protein results in increased transport of Glucose]; Quercetin promotes the reaction [INS1 protein results in increased uptake of Glucose]; Resveratrol inhibits the reaction [Acrolein inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Rosiglitazone inhibits the reaction [Acrolein inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; rutamarin promotes the reaction [INS1 protein results in increased uptake of Glucose]; Sildenafil Citrate promotes the reaction [INS1 protein results in increased import of Glucose]; SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]; SLC30A3 results in increased susceptibility to [Glucose co-treated with INS1 protein]; SLC30A8 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]; SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]; SOD2 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]; sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]; sodium arsenite promotes the reaction [INS1 protein results in decreased chemical synthesis of Glucose]; Sodium Selenite inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Streptozocin inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Testosterone inhibits the reaction [INS1 protein results in increased transport of Glucose]; Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Tolbutamide inhibits the reaction [arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [methylarsonite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide promotes the reaction [Glucose results in increased secretion of INS1 protein]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]; TUG-469 promotes the reaction [Glucose results in increased secretion of INS1 protein]; UGT1A6A protein affects the reaction [Glucose results in increased secretion of INS1 protein]; Vanadates promotes the reaction [INS1 protein results in increased uptake of Glucose]; Wortmannin inhibits the reaction [BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Wortmannin inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Wortmannin inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]; YM-254890 inhibits the reaction [Glucose results in increased secretion of INS1 protein]; YM-254890 inhibits the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Zinc promotes the reaction [INS1 protein results in increased uptake of Glucose]PMID:10199125 PMID:10464266 PMID:10535451 PMID:11574405 PMID:15028607 PMID:15276423 PMID:15516700 PMID:15919478 PMID:16842748 PMID:17179392 PMID:17327424 PMID:17520061 PMID:17922229 PMID:18262572 PMID:18310442 PMID:18545258 PMID:18615583 PMID:18669601 PMID:19052259 PMID:19450229 PMID:20406654 PMID:20471953 PMID:21847688 PMID:22384078 PMID:22479612 PMID:22872759 PMID:22951486 PMID:23795780 PMID:25205820 PMID:25543134 PMID:25851902 PMID:25859628 PMID:25979314 PMID:26512966 PMID:26875785 PMID:26942597 PMID:28180948 PMID:28242381 PMID:28559246 PMID:29111283 PMID:29658312 PMID:29905828 PMID:30562058 PMID:30761839 PMID:31054273 PMID:31095431 PMID:31170414 PMID:31332465 PMID:31776611 PMID:33038468 PMID:33253011 PMID:34225579 PMID:34813903 PMID:35457000 PMID:35679966 PMID:37217659
Ins1multiple interactionsISOINS-IGF2 (Homo sapiens)6480464CTD[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA; [Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein; [Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA; [Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA; avobenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; avobenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; avobenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; avobenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; bisphenol A inhibits the reaction [INS1 protein results in increased uptake of Glucose]; butylbenzyl phthalate promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; Diethylhexyl Phthalate promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; Pioglitazone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; Quercetin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]PMID:23138875 PMID:24349194 PMID:32407875
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