Il6r (interleukin 6 receptor) - Rat Genome Database

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Gene: Il6r (interleukin 6 receptor) Rattus norvegicus
Analyze
Symbol: Il6r
Name: interleukin 6 receptor
RGD ID: 2902
Description: Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. Located in extracellular space and neuronal cell body membrane. Biomarker of congestive heart failure; depressive disorder; myocardial infarction; orchitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor); PARTICIPATES IN interleukin-6 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL6R1; Il6ra; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia10 Iddm54
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,582,020 - 177,646,705 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2177,582,164 - 177,645,221 (-)EnsemblGRCr8
mRatBN7.22175,289,157 - 175,347,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,298,686 - 175,347,536 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2182,447,296 - 182,496,140 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,469,671 - 180,518,517 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,070,810 - 175,119,703 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,196,180 - 189,255,987 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,205,701 - 189,254,628 (-)Ensemblrn6Rnor6.0
Rnor_5.02208,619,391 - 208,679,233 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42182,078,049 - 182,128,135 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2169,240,233 - 169,289,575 (-)NCBICelera
RGSC_v3.12182,028,156 - 182,078,238 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asperentin  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brevianamide A  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
cephaeline  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
daunorubicin  (ISO)
dequalinium  (ISO)
dexamethasone  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
digitoxigenin  (ISO)
digoxigenin  (ISO)
digoxin  (ISO)
dimethyl fumarate  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emetine  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenbendazole  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
glucose  (ISO)
glycidol  (EXP)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Jujuboside A  (ISO)
L-methionine  (ISO)
lanatoside C  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
mebendazole  (ISO)
meclocycline  (ISO)
melittin  (EXP)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methionine sulfoximine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Methylbenzethonium chloride  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
midazolam  (ISO)
minocycline  (ISO)
mitomycin C  (ISO)
mycophenolic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nocodazole  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxytetracycline  (ISO)
ozone  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
puromycin  (ISO)
pyrvinium  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. Abbatecola AM, etal., J Am Geriatr Soc. 2004 Mar;52(3):399-404.
2. Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy. Asimaki A, etal., Circ Arrhythm Electrophysiol. 2011 Oct;4(5):743-52. doi: 10.1161/CIRCEP.111.964890. Epub 2011 Aug 22.
3. Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study. Bagli M, etal., Eur Arch Psychiatry Clin Neurosci. 2003 Feb;253(1):44-8.
4. Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor. Baumann M, etal., J Biol Chem 1990 Nov 15;265(32):19853-62.
5. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome. Bensadoun JC, etal., Eur J Neurosci. 2001 Dec;14(11):1753-61.
6. [Serum levels of interleukin 6 (IL-6) and soluble IL-6 receptor (sIL-6R) in children and adolescents with Graves-Basedow disease]. Bossowski A, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 1999;5(2):85-93.
7. Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain. Brazda V, etal., Mol Pain. 2013 Aug 16;9:42. doi: 10.1186/1744-8069-9-42.
8. Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women. Bustamante M, etal., Eur J Endocrinol. 2007 Nov;157(5):677-84.
9. [Role of the activation of interleukin-6/STAT3 in cholangiocyte proliferation induced by cold ischemia reperfusion and injury]. Chen LP, etal., Zhonghua Wai Ke Za Zhi. 2009 Jun 1;47(11):863-7.
10. Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T Cells. Chen X, etal., Am J Respir Crit Care Med. 2010 Apr 1;181(7):734-42. Epub 2009 Dec 17.
11. Interleukin-6 receptor blockade suppresses subretinal fibrosis in a mouse model. Cui W, etal., Int J Ophthalmol. 2014 Apr 18;7(2):194-7. doi: 10.3980/j.issn.2222-3959.2014.02.02. eCollection 2014.
12. Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. Deten A, etal., Cardiovasc Res. 2002 Aug 1;55(2):329-40.
13. Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model. Dubovy P, etal., Neuron Glia Biol. 2010 Feb;6(1):73-83. Epub 2010 Jun 2.
14. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Escobar-Morreale HF, etal., Obes Res. 2003 Aug;11(8):987-96.
15. Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome. Esteve E, etal., Clin Endocrinol (Oxf). 2006 Jul;65(1):88-91.
16. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Finotto S, etal., Int Immunol. 2007 Jun;19(6):685-93. Epub 2007 May 11.
17. Hepatic regeneration induces transient acute phase reaction: systemic elevation of acute phase reactants and soluble cytokine receptors. Fulop AK, etal., Cell Biol Int. 2001;25(7):585-92.
18. Differential expression of liver interleukin-6 receptor-alpha in female versus male ethanol-consuming rats. Gallucci RM, etal., Alcohol Clin Exp Res. 2004 Mar;28(3):365-73.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Mapping autoimmunity genes. Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
22. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
23. Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure. Helwig BG, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1165-73. Epub 2006 Nov 9.
24. Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2. Hoffmann R, etal., J Hepatol. 1994 Oct;21(4):543-50.
25. Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage. Inomata Y, etal., Biochem Biophys Res Commun 2003 Mar 7;302(2):226-32.
26. CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease. Joetham A, etal., J Immunol. 2011 Jan 1;186(1):113-20. Epub 2010 Nov 29.
27. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
28. Soluble IL-6 receptor in vitreous fluid of patients with proliferative diabetic retinopathy. Kawashima M, etal., Jpn J Ophthalmol. 2007 Mar-Apr;51(2):100-4. Epub 2007 Apr 6.
29. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
30. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Lehtimaki KA, etal., Brain Res Mol Brain Res. 2003 Feb 20;110(2):253-60.
31. [Determination of serum soluble interleukin-6 receptor and soluble gp130 levels in patient with pregnancy induced hypertension and its significance] Li Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2001 Jan;36(1):18-9.
32. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: effect of an NF-kappaB inhibitor. Linard C, etal., Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):427-34.
33. Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity: relationship with abdominal fat deposition. Malavazos AE, etal., Nutr Metab Cardiovasc Dis. 2007 May;17(4):294-302. Epub 2006 Mar 31.
34. Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis. Matsushita K, etal., Lab Invest. 2005 Oct;85(10):1210-23.
35. Soluble interleukin 6 receptor: A novel marker of moderate to severe sleep-related breathing disorder. Mehra R, etal., Arch Intern Med. 2006 Sep 18;166(16):1725-31.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
38. Parathyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor. Mitnick MA, etal., Am J Physiol Endocrinol Metab. 2001 Mar;280(3):E405-12.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Effect of interleukin-6 receptor blockade on feto-maternal outcomes in a rat model of intrauterine inflammation. Ouellet J, etal., J Obstet Gynaecol Res. 2013 Oct;39(10):1456-64. doi: 10.1111/jog.12089. Epub 2013 Jul 15.
41. Interleukin 6 and its soluble receptor are elevated in aqueous humor of patients with uveitis. Petrinovic-Doresic J, etal., Ocul Immunol Inflamm. 1999 Jun;7(2):75-84.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. Association of IL-6 and IL-6R gene polymorphisms with susceptibility to respiratory tract infections in young Finnish men. Rantala A, etal., Hum Immunol. 2011 Jan;72(1):63-8. Epub 2010 Oct 15.
45. GOA pipeline RGD automated data pipeline
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis. Rival C, etal., J Reprod Immunol. 2006 Jun;70(1-2):43-58. Epub 2006 Feb 3.
48. A new regulation of IL-6 production in adult cardiomyocytes by beta-adrenergic and IL-1 beta receptors and induction of cellular hypertrophy by IL-6 trans-signalling. Szabo-Fresnais N, etal., Cell Signal. 2010 Jul;22(7):1143-52. Epub 2010 Mar 11.
49. Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han. Wang M, etal., Brain Res. 2010 Apr 23;1327:1-5. doi: 10.1016/j.brainres.2010.02.067. Epub 2010 Mar 1.
50. Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain. Watanabe D, etal., Eur J Neurosci. 1996 Aug;8(8):1630-40.
51. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8
52. Inhibition of interleukin-6 attenuates erectile dysfunction in a rat model of nerve-sparing radical prostatectomy. Yamashita S, etal., J Sex Med. 2011 Jul;8(7):1957-64. doi: 10.1111/j.1743-6109.2011.02283.x. Epub 2011 Apr 14.
53. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Yokota S, etal., Lancet. 2008 Mar 22;371(9617):998-1006. doi: 10.1016/S0140-6736(08)60454-7.
54. Association of genetic variations in IL-6/IL-6R pathway genes with gastric cancer risk in a Chinese population. Zhang JZ, etal., Gene. 2017 Aug 5;623:1-4. doi: 10.1016/j.gene.2017.04.038. Epub 2017 Apr 23.
55. Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model. Zhang L, etal., Dig Dis Sci. 2013 Aug;58(8):2187-96. doi: 10.1007/s10620-013-2656-3. Epub 2013 Apr 16.
56. Chimeric molecule IL-6/soluble IL-6 receptor is a potent mitogen for fetal hepatocytes. Zvibel I, etal., J Cell Physiol. 2004 Aug;200(2):245-52.
Additional References at PubMed
PMID:1312474   PMID:2261637   PMID:10510402   PMID:11884403   PMID:12419823   PMID:12633863   PMID:12643274   PMID:12748171   PMID:12829785   PMID:15579373   PMID:16034137   PMID:18313228  
PMID:18357518   PMID:18719127   PMID:19293443   PMID:19861414   PMID:23706525   PMID:26191141   PMID:26563755   PMID:28776758   PMID:31131445   PMID:32681356   PMID:33189652  


Genomics

Comparative Map Data
Il6r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,582,020 - 177,646,705 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2177,582,164 - 177,645,221 (-)EnsemblGRCr8
mRatBN7.22175,289,157 - 175,347,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,298,686 - 175,347,536 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2182,447,296 - 182,496,140 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,469,671 - 180,518,517 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,070,810 - 175,119,703 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,196,180 - 189,255,987 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,205,701 - 189,254,628 (-)Ensemblrn6Rnor6.0
Rnor_5.02208,619,391 - 208,679,233 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42182,078,049 - 182,128,135 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2169,240,233 - 169,289,575 (-)NCBICelera
RGSC_v3.12182,028,156 - 182,078,238 (-)NCBI
Cytogenetic Map2q34NCBI
IL6R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381154,405,343 - 154,469,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1154,405,193 - 154,469,450 (+)Ensemblhg38GRCh38
GRCh371154,377,819 - 154,441,926 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361152,644,293 - 152,706,812 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341151,190,741 - 151,253,261NCBI
Celera1127,449,298 - 127,511,851 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1125,740,964 - 125,805,584 (+)NCBIHuRef
CHM1_11155,774,020 - 155,838,256 (+)NCBICHM1_1
T2T-CHM13v2.01153,542,427 - 153,606,601 (+)NCBIT2T-CHM13v2.0
Il6ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,776,631 - 89,820,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,771,366 - 89,820,503 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38389,869,324 - 89,913,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,864,059 - 89,913,196 (-)Ensemblmm10GRCm38
MGSCv37389,673,246 - 89,717,084 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36389,962,736 - 89,998,969 (-)NCBIMGSCv36mm8
Celera389,906,161 - 89,949,620 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.19NCBI
Il6r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955545950,765 - 981,762 (+)Ensembl
ChiLan1.0NW_004955545932,814 - 979,359 (+)NCBIChiLan1.0ChiLan1.0
IL6R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2195,364,609 - 95,427,592 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,099,912 - 95,162,870 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01129,761,914 - 129,824,386 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,374,078 - 133,433,089 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,374,078 - 133,433,089 (+)EnsemblpanPan2panpan1.1
IL6R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,877,731 - 42,920,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,880,885 - 42,920,090 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha742,368,082 - 42,410,484 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0742,747,387 - 42,789,817 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,747,374 - 42,790,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,526,574 - 42,569,177 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,580,411 - 42,622,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,864,074 - 42,906,503 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il6r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,027,301 - 25,051,502 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,057,771 - 4,081,885 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,055,438 - 4,081,876 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl495,322,433 - 95,381,282 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1495,322,426 - 95,381,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,202,230 - 104,250,108 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL6R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1209,345,723 - 9,418,963 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl209,361,152 - 9,396,610 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660388,700,264 - 8,762,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,910,112 - 2,946,886 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248852,910,367 - 2,946,916 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il6r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1363,738,759 - 63,787,388 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il6r
385 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1044
Count of miRNA genes:336
Interacting mature miRNAs:446
Transcripts:ENSRNOT00000028234
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2176840779178247591Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
RH127619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22175,298,879 - 175,299,066 (+)MAPPERmRatBN7.2
Rnor_6.02189,205,895 - 189,206,081NCBIRnor6.0
Rnor_5.02208,629,262 - 208,629,448UniSTSRnor5.0
RGSC_v3.42182,078,245 - 182,078,431UniSTSRGSC3.4
Celera2169,240,429 - 169,240,615UniSTS
RH 3.4 Map21153.7UniSTS
Cytogenetic Map2q34UniSTS
RH132797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22175,348,766 - 175,348,951 (+)MAPPERmRatBN7.2
Rnor_6.02189,255,795 - 189,255,979NCBIRnor6.0
Rnor_5.02208,679,022 - 208,679,206UniSTSRnor5.0
RGSC_v3.42182,129,378 - 182,129,562UniSTSRGSC3.4
Celera2169,290,818 - 169,291,002UniSTS
Cytogenetic Map2q34UniSTS
BM389764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22175,330,189 - 175,330,403 (+)MAPPERmRatBN7.2
Rnor_6.02189,237,212 - 189,237,425NCBIRnor6.0
Rnor_5.02208,660,483 - 208,660,696UniSTSRnor5.0
RGSC_v3.42182,109,587 - 182,109,800UniSTSRGSC3.4
Celera2169,271,610 - 169,271,823UniSTS
RH 3.4 Map21154.4UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000028234   ⟹   ENSRNOP00000028234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,596,362 - 177,645,221 (-)Ensembl
mRatBN7.2 Ensembl2175,298,686 - 175,347,536 (-)Ensembl
Rnor_6.0 Ensembl2189,205,701 - 189,254,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156101   ⟹   ENSRNOP00000106230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,582,164 - 177,645,221 (-)Ensembl
RefSeq Acc Id: NM_017020   ⟹   NP_058716
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,596,360 - 177,645,209 (-)NCBI
mRatBN7.22175,298,684 - 175,347,524 (-)NCBI
Rnor_6.02189,205,699 - 189,254,552 (-)NCBI
Rnor_5.02208,619,391 - 208,679,233 (-)NCBI
RGSC_v3.42182,078,049 - 182,128,135 (-)RGD
Celera2169,240,233 - 169,289,575 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232587   ⟹   XP_006232649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,582,020 - 177,646,705 (-)NCBI
mRatBN7.22175,297,940 - 175,347,719 (-)NCBI
Rnor_6.02189,204,861 - 189,255,987 (-)NCBI
Rnor_5.02208,619,391 - 208,679,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232588   ⟹   XP_006232650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,582,020 - 177,646,705 (-)NCBI
mRatBN7.22175,289,157 - 175,347,718 (-)NCBI
Rnor_6.02189,196,180 - 189,255,986 (-)NCBI
Rnor_5.02208,619,391 - 208,679,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761127   ⟹   XP_008759349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,596,360 - 177,646,705 (-)NCBI
mRatBN7.22175,298,684 - 175,347,710 (-)NCBI
Rnor_6.02189,205,699 - 189,255,980 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010063582
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,582,020 - 177,646,705 (-)NCBI
RefSeq Acc Id: NP_058716   ⟸   NM_017020
- Peptide Label: precursor
- UniProtKB: P22273 (UniProtKB/Swiss-Prot),   G3V8T6 (UniProtKB/TrEMBL),   A6J6I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232650   ⟸   XM_006232588
- Peptide Label: isoform X3
- UniProtKB: P22273 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232649   ⟸   XM_006232587
- Peptide Label: isoform X2
- UniProtKB: P22273 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008759349   ⟸   XM_008761127
- Peptide Label: isoform X1
- UniProtKB: P22273 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028234   ⟸   ENSRNOT00000028234
Ensembl Acc Id: ENSRNOP00000106230   ⟸   ENSRNOT00000156101
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691484
Promoter ID:EPDNEW_R2009
Type:multiple initiation site
Name:Il6r_1
Description:interleukin 6 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02189,254,654 - 189,254,714EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2902 AgrOrtholog
BioCyc Gene G2FUF-52388 BioCyc
Ensembl Genes ENSRNOG00000020811 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028234 ENTREZGENE
  ENSRNOT00000156101 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Hematopoietin_rcpt_L_F3_CS UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  TypeI_recpt_CBD UniProtKB/Swiss-Prot
NCBI Gene 24499 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  CYTOKINE RECEPTOR COMMON SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam IL6Ra-bind UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
PhenoGen Il6r PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  HEMATOPO_REC_L_F3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020811 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
UniProt A0ABK0LMW2_RAT UniProtKB/TrEMBL
  A6J6I0 ENTREZGENE, UniProtKB/TrEMBL
  G3V8T6 ENTREZGENE, UniProtKB/TrEMBL
  IL6RA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-01-24 Il6r  interleukin 6 receptor  Il6ra  interleukin 6 receptor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Il6ra  interleukin 6 receptor, alpha  Il6r  interleukin 6 receptor  Symbol and Name updated 1299863 APPROVED
2002-11-06 Il6r  interleukin 6 receptor    Interleukin 6 receptor  Name updated 625702 APPROVED
2002-06-10 Il6r  Interleukin 6 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping maps within the Cari2 QTL region and may be a candidate gene for this QTL locus 70860
gene_process may be involved in neuroprotection from NMDA-induced retinal damage 727510