Il4 Rat Gene (interleukin 4) - Rat Genome Database

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Keyword

Gene:
Il4 ( Rattus norvegicus )
interleukin 4
Description: Th2-type cytokine; may be involved in inflammatory response in eosinophils
Synonyms: Il4e12;
ArrayIDs: 1371128_at; 5914993; A_43_P16025; GE1202883; X16058cds_s_at; 6309123; X53087cds_at; A_44_P193188; 5925528; 6115650;  (details...)
Gene Type: protein-coding

Additional Data

Candidate gene for: Eau7 - Experimental allergic uveoretinitis QTL 7

Markers: D10Mgh9 D10Wox9

Homologs
Homo sapiens: IL4     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Il4     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Il4 Rat Celera Assembly 10 37115496 - 37120965
RGSC genome assembly v3.4 10 39074582 - 39080134
Cytogenetic 10 q22
genome assembly 3.1 10 39083152 - 39088705
Mus musculus Il4 Mouse genome assembly build 36.1 11 53425970 - 53432167
Cytogenetic 11 11 B1.3
Homo sapiens IL4 human genome assembly 5 132037271 - 132046267
Human genome assembly build 36.2 5 132037272 - 132046267
Cytogenetic 5 q31.1

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Other Map Data:
Associated SSLP Map Locations
STS D10Mgh9 SHRSP x BN 10 36.2799
genome assembly 3.1 10 39087845 - 39087975
RH 3.4 10 404
RH 2.0 10 433.4
RGSC genome assembly v3.4 10 39079274 - 39079404
STS D10Wox9 genome assembly 3.1 10 39087792 - 39087980
RH 3.4 10 406.6
RH 2.0 10 446
RGSC genome assembly v3.4 10 39079221 - 39079409

Annotation
Molecular Function

Gene Ontology

protein binding,  growth factor activity,  interleukin-4 receptor binding ... (details...)
Biological Process

Gene Ontology

positive regulation of isotype switching to IgG isotypes,  positive regulation of transcription factor activity,  regulation of immune response ... (details...)
Cellular Component

Gene Ontology

extracellular space,  extracellular region (details...)
Disease

Ontology

Multiple Sclerosis (details...)
Regulation

Note Reference

inflammatory response causes increase of mRNA in eosinophils 625643

External Links
Databases
DATABASE ID SOURCE
SMART: IL4_13 IPI
PROSITE: INTERLEUKIN_4_13 IPI
UNIPARC: UPI000012D4C8 IPI
UNIPARC: UPI0000232FCF IPI
KEGG Report: rno:287287 ENTREZGENE
HomoloGene Group ID: 491 ENTREZGENE
Germonline: 2898
Pfam: IL4 IPI
KEGG Pathway: 04640 ENTREZGENE
KEGG Pathway: 04664 ENTREZGENE
KEGG Pathway: 04060 ENTREZGENE
KEGG Pathway: 05320 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
KEGG Pathway: 05330 ENTREZGENE
KEGG Pathway: 04630 ENTREZGENE
KEGG Pathway: 05310 ENTREZGENE
InterPro: Interleukin_4_13. IPI
InterPro: 4_helix_cytokine-like_core. IPI
InterPro: 4_helix_cytokine_core. IPI
InterPro: Interleukin-4/-13_CS. IPI
InterPro: Interleukin_4. IPI
Ensembl Protein: ENSRNOP00000060867 IPI
Ensembl Protein: ENSRNOP00000010029 IPI
IPI: IPI00454514 IPI
IPI: IPI00195650 IPI
Gene3D-CATH: 4_helix_cytokine_core IPI
Entrez Gene: Il4 ENTREZGENE
PIRSF: Interleukin_4 IPI
Ensembl Genes: ENSRNOG00000007624 IPI
UniProt: IL4_RAT IPI
UniProt: Q6RIC4_RAT IPI
RatMap: 34105 ENTREZGENE
Superfamily-SCOP: 4_helix_cytokine IPI
PANTHER: Interleukin_4 IPI
PRINTS: INTERLEUKIN4. IPI
Sequences
Nucleotide: X16058 Get FASTA Search GEO Profiles
Nucleotide: AY496861 Get FASTA Search GEO Profiles
Nucleotide: NM_201270 Get FASTA Search GEO Profiles
Nucleotide: X53089 Get FASTA Search GEO Profiles
Nucleotide: AC107611 Get FASTA Search GEO Profiles
Nucleotide: CH473948 Get FASTA Search GEO Profiles
Nucleotide: X53088 Get FASTA Search GEO Profiles
Nucleotide: X53087 Get FASTA Search GEO Profiles
(View all 8 Nucleotide Accessions)
Protein: EDM04390 Get FASTA
Protein: NP_958427 Get FASTA
Protein: AAR87867 Get FASTA
Protein: CAA37256 Get FASTA
Protein: EDM04391 Get FASTA
Protein: EDM04393 Get FASTA
Protein: P20096 Get FASTA
Protein: CAC16091 Get FASTA
Protein: EDM04392 Get FASTA
Protein: Q6RIC4 Get FASTA
(View all 10 Protein Accessions)
Clusters
UniGene: 108255

References
Curated References
6 references in RGD related to Il4

Other References
21 other references at PubMed related to Il4

Database Information
RGD ID 2898
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-JUN-02: Il4 Interleukin 4 APPROVED Symbol and Name status set to approved 70586