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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:47495
Term: N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
Definition: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.
Chemical ID: MESH:C063509
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4decreases expressionISOIL4 (Homo sapiens)6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL4 mRNAPMID:11886533
Il4decreases secretionISOIL4 (Homo sapiens)6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased secretion of IL4 proteinPMID:11886533
Il4multiple interactionsISOIL4 (Homo sapiens)6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]PMID:12230500
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