Gene:	Gck ( Rattus norvegicus ) glucokinase
Description:	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; may mediate glucosensing in glucose-inhibited and glucose-excited neurons
Synonyms:	RNGK2; GLUKA;
ArrayIDs:	6278165; 6480809; 1387312_a_at; 6252277; 6432505; A_44_P306618; 6379357; X53588_at; 6224674; GE19826; 5786560; 5772637; 6220760; 6296565; 5929711; 6199545; 6181977; A_42_P748948; 6172541;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Niddm37 - Non-insulin dependent diabetes mellitus QTL 37
Markers:	D14Arb12
Homologs
Homo sapiens: GCK     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Gck     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Gck genome assembly 3.1 14 86591662 - 86606868     Rat Celera Assembly 14 79669432 - 79684636     RGSC genome assembly v3.4 14 86572518 - 86587723     Cytogenetic 14 q21 Mus musculus Gck Mouse genome assembly build 36.1 11 5800826 - 5849602     Cytogenetic 11 11 A1 Homo sapiens GCK human genome assembly 7 43957109 - 43972127     Human genome assembly build 36.2 7 44150395 - 44195563     Cytogenetic 7 p15.3-p15.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Other Map Data:	Associated SSLP Map Locations No mapping information currently available in RGD for D14Arb12
Annotation
Molecular Function	Gene Ontology protein phosphatase binding,  nucleotide binding,  kinase activity ...  (details...)
Biological Process	Note Reference mediates glucose homeostasis and insulin secretion in response to glucose in the beta-cells; controls glucose uptake in the liver 628440 Gene Ontology positive regulation of insulin secretion,  cellular response to glucose starvation,  second-messenger-mediated signaling ...  (details...)
Cellular Component	Gene Ontology nucleus,  mitochondrion,  soluble fraction ...  (details...)
Disease	Note Reference mutations in humans cause maturity-onset diabetes of the youth or hyperinsulinemia 628440 Ontology Diabetes Mellitus, Experimental,  Hypertension,  Diabetes Mellitus ...  (details...)
Phenotype	Ontology increased circulating free fatty acid level,  decreased circulating glucose level,  increased circulating triglyceride level (details...)
Expression	Note Reference expressed in hepatocytes, pancreatic beta-cells, and neuroendocrine cells of the brain and gut 628440
Pathway	Ontology glycogen biosynthetic pathway,  fructose and mannose metabolic pathway,  aminosugars metabolic pathway ...  (details...)
Transcript structure	Note Reference contains two distinct promoters for a tissue-specific control of the expression 628440
Regulation	Note Reference mRNA level is decreased by glucagon through increases on cAMP 628440 in the liver, insulin and glucagon mediate the activity at the level of gene transcription in response to fasting and refeeding; in pancreatic beta-cells, glucose levels modulate the activity 628440 cAMP represses gene expression in the liver but increases the mRNA level in pancreatic beta-cells 628440
External Links
Databases	DATABASE ID SOURCE PROSITE: HEXOKINASES IPI UNIPARC: UPI00000E8A93 IPI UNIPARC: UPI000012CFAF IPI UNIPARC: UPI0001B7A6FA IPI UNIPARC: UPI000002AB78 IPI UNIPARC: UPI000002AB79 IPI KEGG Report: rno:24385 ENTREZGENE HomoloGene Group ID: 55440 ENTREZGENE Germonline: 2670 Pfam: Hexokinase_2 IPI Pfam: Hexokinase_1 IPI KEGG Pathway: 04950 ENTREZGENE KEGG Pathway: 00010 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 00520 ENTREZGENE KEGG Pathway: 01100 ENTREZGENE KEGG Pathway: 00500 ENTREZGENE KEGG Pathway: 00521 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 00052 ENTREZGENE InterPro: Hexokinase_CS. IPI InterPro: Hexokinase. IPI IPI: IPI00190888 IPI IPI: IPI00202358 IPI IPI: IPI00948362 IPI IPI: IPI00213666 IPI IPI: IPI00231947 IPI Ensembl Protein: ENSRNOP00000019625 IPI Ensembl Protein: ENSRNOP00000063206 IPI Ensembl Protein: ENSRNOP00000043229 IPI Entrez Gene: Gck ENTREZGENE UniProt: Q78E09_RAT IPI UniProt: Q64596_RAT IPI UniProt: HXK4_RAT IPI UniProt: HXK4_RAT IPI UniProt: HXK4_RAT IPI Ensembl Genes: ENSRNOG00000014447 IPI RatMap: 33966 ENTREZGENE PANTHER: Hexokinase IPI PRINTS: HEXOKINASE. IPI
Sequences	Nucleotide: X53589 Get FASTA Search GEO Profiles Nucleotide: X53588 Get FASTA Search GEO Profiles Nucleotide: M58759 Get FASTA Search GEO Profiles Nucleotide: M25807 Get FASTA Search GEO Profiles Nucleotide: J04218 Get FASTA Search GEO Profiles Nucleotide: X53590 Get FASTA Search GEO Profiles Nucleotide: M30770 Get FASTA Search GEO Profiles Nucleotide: M24952 Get FASTA Search GEO Profiles Nucleotide: M24944 Get FASTA Search GEO Profiles Nucleotide: CH473963 Get FASTA Search GEO Profiles Nucleotide: NM_012565 Get FASTA Search GEO Profiles (View all 11 Nucleotide Accessions) Protein: Q78E09 Get FASTA Protein: Q64596 Get FASTA Protein: P17712 Get FASTA Protein: CAA37658 Get FASTA Protein: CAA37657 Get FASTA Protein: AAA41236 Get FASTA Protein: AAA41239 Get FASTA Protein: AAA41229 Get FASTA Protein: CAA37659 Get FASTA Protein: AAA41231 Get FASTA Protein: AAA41230 Get FASTA Protein: EDM00326 Get FASTA Protein: EDM00325 Get FASTA Protein: EDM00324 Get FASTA Protein: EDM00323 Get FASTA Protein: NP_036697 Get FASTA (View all 16 Protein Accessions)
Clusters	UniGene: 10447
References
Curated References	44 references in RGD related to Gck
Other References	58 other references at PubMed related to Gck
Database Information
RGD ID	2670
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Gck Glucokinase APPROVED Symbol and Name status set to approved 70586