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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2670
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gck
Name: glucokinase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gckaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of GCK mRNAPMID:22298810
Gckdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GCK mRNAPMID:16054898 PMID:23238561
Gckincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of GCK mRNAPMID:21215274
Gckmultiple interactionsEXP 6480464CTDAHR protein alternative form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GCK mRNA]PMID:21215274
Gckaffects expressionISOGck (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of GCK mRNAPMID:18343893 PMID:26377647
Gckdecreases expressionISOGck (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GCK mRNAPMID:15800033 PMID:18163543 PMID:18295293 PMID:18796159 PMID:19770486 PMID:22539624 PMID:23238561 PMID:27562557
Gckmultiple interactionsISOGck (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GCK mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of GCK mRNAPMID:17942748 PMID:25975270
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