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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2670
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gck
Name: glucokinase
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gckdecreases expressionISOGck (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of GCK mRNAPMID:30362509
Gckmultiple interactionsISOGck (Mus musculus)6480464CTDPlant Extracts inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic Trioxide] which results in decreased activity of GCK protein]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of GCK mRNA]PMID:30362509 PMID:32226249
Gckmultiple interactionsISOGCK (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GCK protein]PMID:26598702
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